Treatment options for hypercalcemia after cosmetic oil injections: Lessons from human tissue cultures and a pilot intervention study

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Treatment options for hypercalcemia after cosmetic oil injections : Lessons from human tissue cultures and a pilot intervention study. / Yahyavi, Sam Kafai; Theilade, Simone; Hansen, Ditte; Berg, Jais Oliver; Andreassen, Christine Hjorth; Lorenzen, Mette; Jørgensen, Anne; Juul, Anders; Faber, Jens; Eldrup, Ebbe; Jensen, Martin Blomberg.

In: Bone, Vol. 154, 116244, 2022.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Yahyavi, SK, Theilade, S, Hansen, D, Berg, JO, Andreassen, CH, Lorenzen, M, Jørgensen, A, Juul, A, Faber, J, Eldrup, E & Jensen, MB 2022, 'Treatment options for hypercalcemia after cosmetic oil injections: Lessons from human tissue cultures and a pilot intervention study', Bone, vol. 154, 116244. https://doi.org/10.1016/j.bone.2021.116244

APA

Yahyavi, S. K., Theilade, S., Hansen, D., Berg, J. O., Andreassen, C. H., Lorenzen, M., Jørgensen, A., Juul, A., Faber, J., Eldrup, E., & Jensen, M. B. (2022). Treatment options for hypercalcemia after cosmetic oil injections: Lessons from human tissue cultures and a pilot intervention study. Bone, 154, [116244]. https://doi.org/10.1016/j.bone.2021.116244

Vancouver

Yahyavi SK, Theilade S, Hansen D, Berg JO, Andreassen CH, Lorenzen M et al. Treatment options for hypercalcemia after cosmetic oil injections: Lessons from human tissue cultures and a pilot intervention study. Bone. 2022;154. 116244. https://doi.org/10.1016/j.bone.2021.116244

Author

Yahyavi, Sam Kafai ; Theilade, Simone ; Hansen, Ditte ; Berg, Jais Oliver ; Andreassen, Christine Hjorth ; Lorenzen, Mette ; Jørgensen, Anne ; Juul, Anders ; Faber, Jens ; Eldrup, Ebbe ; Jensen, Martin Blomberg. / Treatment options for hypercalcemia after cosmetic oil injections : Lessons from human tissue cultures and a pilot intervention study. In: Bone. 2022 ; Vol. 154.

Bibtex

@article{592a85d2e1334f4c9e6dca21a6972fab,
title = "Treatment options for hypercalcemia after cosmetic oil injections: Lessons from human tissue cultures and a pilot intervention study",
abstract = "Objective: Granuloma formation following self-administered cosmetic oil injections can lead to severe hypercalcemia and renal calcifications due to extra-renal vitamin D activation. This translational study aims to identify Prednisolone sparing therapeutics for hypercalcemia after development of granulomatous disease secondary to paraffin oil injections. Materials and methods: Granuloma tissue isolated from five men were cultured ex vivo and treated with selected drugs to block generation of activated vitamin D (1,25(OH)2D3). In a retrospective study, we included data before and during different treatments of 21 men with paraffin oil induced granulomatous hypercalcemia (46 treatment courses) where serum calcium, parathyroid hormone, vitamin D metabolites, creatinine and inflammatory markers were measured. Results: Addition of Ketoconazole or Ciclosporin to granuloma tissue ex vivo culture, significantly suppressed production of 1,25(OH)2D3 after 48 h (both p < 0.05). Prednisolone was the first treatment option in most men and lowered serum levels of ionized calcium after 1, 2, 3 and 6 months compared with baseline (p < 0.05). Ketoconazole or Hydroxychloroquine had no significant effect on serum calcium levels and were unable to reduce the concomitant daily Prednisolone doses (p > 0.05). Azathioprine did not reduce calcium levels. However, addition of Tacrolimus to Prednisolone treatment enabled a reduction in Prednisolone dose after 3 months (p = 0.014), but with no additional effect on calcium homeostasis. Conclusion: This study verifies that Prednisolone is an effective treatment and suggests that calcineurin inhibitors may be used as Prednisolone sparing treatment for paraffin oil-induced granulomatous hypercalcemia. Randomized clinical trials are needed to determine clinical efficacy.",
keywords = "Cosmetic oil injections, Extra-renal vitamin D activation, Granuloma, Hypercalcemia, Prednisolone, Tacrolimus",
author = "Yahyavi, {Sam Kafai} and Simone Theilade and Ditte Hansen and Berg, {Jais Oliver} and Andreassen, {Christine Hjorth} and Mette Lorenzen and Anne J{\o}rgensen and Anders Juul and Jens Faber and Ebbe Eldrup and Jensen, {Martin Blomberg}",
note = "Publisher Copyright: {\textcopyright} 2021 The Authors",
year = "2022",
doi = "10.1016/j.bone.2021.116244",
language = "English",
volume = "154",
journal = "Bone",
issn = "8756-3282",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Treatment options for hypercalcemia after cosmetic oil injections

T2 - Lessons from human tissue cultures and a pilot intervention study

AU - Yahyavi, Sam Kafai

AU - Theilade, Simone

AU - Hansen, Ditte

AU - Berg, Jais Oliver

AU - Andreassen, Christine Hjorth

AU - Lorenzen, Mette

AU - Jørgensen, Anne

AU - Juul, Anders

AU - Faber, Jens

AU - Eldrup, Ebbe

AU - Jensen, Martin Blomberg

N1 - Publisher Copyright: © 2021 The Authors

PY - 2022

Y1 - 2022

N2 - Objective: Granuloma formation following self-administered cosmetic oil injections can lead to severe hypercalcemia and renal calcifications due to extra-renal vitamin D activation. This translational study aims to identify Prednisolone sparing therapeutics for hypercalcemia after development of granulomatous disease secondary to paraffin oil injections. Materials and methods: Granuloma tissue isolated from five men were cultured ex vivo and treated with selected drugs to block generation of activated vitamin D (1,25(OH)2D3). In a retrospective study, we included data before and during different treatments of 21 men with paraffin oil induced granulomatous hypercalcemia (46 treatment courses) where serum calcium, parathyroid hormone, vitamin D metabolites, creatinine and inflammatory markers were measured. Results: Addition of Ketoconazole or Ciclosporin to granuloma tissue ex vivo culture, significantly suppressed production of 1,25(OH)2D3 after 48 h (both p < 0.05). Prednisolone was the first treatment option in most men and lowered serum levels of ionized calcium after 1, 2, 3 and 6 months compared with baseline (p < 0.05). Ketoconazole or Hydroxychloroquine had no significant effect on serum calcium levels and were unable to reduce the concomitant daily Prednisolone doses (p > 0.05). Azathioprine did not reduce calcium levels. However, addition of Tacrolimus to Prednisolone treatment enabled a reduction in Prednisolone dose after 3 months (p = 0.014), but with no additional effect on calcium homeostasis. Conclusion: This study verifies that Prednisolone is an effective treatment and suggests that calcineurin inhibitors may be used as Prednisolone sparing treatment for paraffin oil-induced granulomatous hypercalcemia. Randomized clinical trials are needed to determine clinical efficacy.

AB - Objective: Granuloma formation following self-administered cosmetic oil injections can lead to severe hypercalcemia and renal calcifications due to extra-renal vitamin D activation. This translational study aims to identify Prednisolone sparing therapeutics for hypercalcemia after development of granulomatous disease secondary to paraffin oil injections. Materials and methods: Granuloma tissue isolated from five men were cultured ex vivo and treated with selected drugs to block generation of activated vitamin D (1,25(OH)2D3). In a retrospective study, we included data before and during different treatments of 21 men with paraffin oil induced granulomatous hypercalcemia (46 treatment courses) where serum calcium, parathyroid hormone, vitamin D metabolites, creatinine and inflammatory markers were measured. Results: Addition of Ketoconazole or Ciclosporin to granuloma tissue ex vivo culture, significantly suppressed production of 1,25(OH)2D3 after 48 h (both p < 0.05). Prednisolone was the first treatment option in most men and lowered serum levels of ionized calcium after 1, 2, 3 and 6 months compared with baseline (p < 0.05). Ketoconazole or Hydroxychloroquine had no significant effect on serum calcium levels and were unable to reduce the concomitant daily Prednisolone doses (p > 0.05). Azathioprine did not reduce calcium levels. However, addition of Tacrolimus to Prednisolone treatment enabled a reduction in Prednisolone dose after 3 months (p = 0.014), but with no additional effect on calcium homeostasis. Conclusion: This study verifies that Prednisolone is an effective treatment and suggests that calcineurin inhibitors may be used as Prednisolone sparing treatment for paraffin oil-induced granulomatous hypercalcemia. Randomized clinical trials are needed to determine clinical efficacy.

KW - Cosmetic oil injections

KW - Extra-renal vitamin D activation

KW - Granuloma

KW - Hypercalcemia

KW - Prednisolone

KW - Tacrolimus

U2 - 10.1016/j.bone.2021.116244

DO - 10.1016/j.bone.2021.116244

M3 - Journal article

C2 - 34757214

AN - SCOPUS:85118693596

VL - 154

JO - Bone

JF - Bone

SN - 8756-3282

M1 - 116244

ER -

ID: 290250199