TY - JOUR

T1 - Continuous peripheral perfusion index in patients admitted to hospital wards – An observational study

AU - Rasmussen, Patrick S.

AU - Aasvang, Eske K.

AU - Olsen, Rasmus M.

AU - Haahr-Raunkjaer, Camilla

AU - Elvekjaer, Mikkel

AU - Sørensen, Helge B.D.

AU - Meyhoff, Christian S.

PY - 2021

Y1 - 2021

N2 - Introduction: Risk patients admitted to hospital wards may quickly develop haemodynamic deterioration and early recognition has high priority to allow preventive intervention. The peripheral perfusion index (PPI) may be an indicator of circulatory distress by assessing peripheral perfusion non-invasively from photoplethysmography. We aimed to describe the characteristics of PPI in hospitalized patients since this is not well-studied. Materials and Methods: Patients admitted due to either acute exacerbation of chronic obstructive pulmonary disease (AECOPD) or after major abdominal cancer surgery were included in this study. Patients were monitored continuously up to 96 hours with a pulse oximeter. Comparisons between median PPI each day, time of day and admission type were described with mean difference (MD) and were analysed using Wilcoxon rank sum test and related to morbidity and mortality. Results: PPI data from 291 patients were recorded for a total of 9279 hours. Median PPI fell from 1.4 (inter quartile range, IQR 0.9-2.3) on day 1 to 1.0 (IQR 0.6-1.6) on day 4. Significant differences occurred between PPI day vs evening (MD = 0.18, 95% CI 0.16-0.20, P =.028), day vs night (MD = 0.56, 95% CI 0.49-0.62, P <.0001) and evening vs night (MD = 0.38, 95% CI 0.33-0.42, P =.002). No significant difference in median PPI between AECOPD and surgical patients was found (MD = 0.15, 95% CI −0.08-0.38, P =.62). Conclusion: Lower PPI during daytime vs evening and night-time were seen for both populations. The highest frequency of serious adverse events and mortality was seen among patients with low median PPI. The clinical impact of PPI monitoring needs further confirmation.

AB - Introduction: Risk patients admitted to hospital wards may quickly develop haemodynamic deterioration and early recognition has high priority to allow preventive intervention. The peripheral perfusion index (PPI) may be an indicator of circulatory distress by assessing peripheral perfusion non-invasively from photoplethysmography. We aimed to describe the characteristics of PPI in hospitalized patients since this is not well-studied. Materials and Methods: Patients admitted due to either acute exacerbation of chronic obstructive pulmonary disease (AECOPD) or after major abdominal cancer surgery were included in this study. Patients were monitored continuously up to 96 hours with a pulse oximeter. Comparisons between median PPI each day, time of day and admission type were described with mean difference (MD) and were analysed using Wilcoxon rank sum test and related to morbidity and mortality. Results: PPI data from 291 patients were recorded for a total of 9279 hours. Median PPI fell from 1.4 (inter quartile range, IQR 0.9-2.3) on day 1 to 1.0 (IQR 0.6-1.6) on day 4. Significant differences occurred between PPI day vs evening (MD = 0.18, 95% CI 0.16-0.20, P =.028), day vs night (MD = 0.56, 95% CI 0.49-0.62, P <.0001) and evening vs night (MD = 0.38, 95% CI 0.33-0.42, P =.002). No significant difference in median PPI between AECOPD and surgical patients was found (MD = 0.15, 95% CI −0.08-0.38, P =.62). Conclusion: Lower PPI during daytime vs evening and night-time were seen for both populations. The highest frequency of serious adverse events and mortality was seen among patients with low median PPI. The clinical impact of PPI monitoring needs further confirmation.

U2 - 10.1111/aas.13711

DO - 10.1111/aas.13711

M3 - Journal article

C2 - 32959371

AN - SCOPUS:85091612406

VL - 65

SP - 257

EP - 265

JO - Acta Anaesthesiologica Scandinavica

JF - Acta Anaesthesiologica Scandinavica

SN - 0001-5172

IS - 2

ER -