The significance of mitochondrial haplogroups in preeclampsia risk

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

The significance of mitochondrial haplogroups in preeclampsia risk. / Wendelboe Olsen, Kristina; Hedley, Paula L.; Hagen, Christian M.; Rode, Line; Placing, Sophie; Wøjdemann, Karen R.; Shalmi, Anne Cathrine; Sundberg, Karin; Nørremølle, Anne; Tabor, Ann; Elson, Joanna L.; Christiansen, Michael.

I: Pregnancy Hypertension, Bind 34, 2023, s. 146-151.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Wendelboe Olsen, K, Hedley, PL, Hagen, CM, Rode, L, Placing, S, Wøjdemann, KR, Shalmi, AC, Sundberg, K, Nørremølle, A, Tabor, A, Elson, JL & Christiansen, M 2023, 'The significance of mitochondrial haplogroups in preeclampsia risk', Pregnancy Hypertension, bind 34, s. 146-151. https://doi.org/10.1016/j.preghy.2023.11.001

APA

Wendelboe Olsen, K., Hedley, P. L., Hagen, C. M., Rode, L., Placing, S., Wøjdemann, K. R., Shalmi, A. C., Sundberg, K., Nørremølle, A., Tabor, A., Elson, J. L., & Christiansen, M. (2023). The significance of mitochondrial haplogroups in preeclampsia risk. Pregnancy Hypertension, 34, 146-151. https://doi.org/10.1016/j.preghy.2023.11.001

Vancouver

Wendelboe Olsen K, Hedley PL, Hagen CM, Rode L, Placing S, Wøjdemann KR o.a. The significance of mitochondrial haplogroups in preeclampsia risk. Pregnancy Hypertension. 2023;34:146-151. https://doi.org/10.1016/j.preghy.2023.11.001

Author

Wendelboe Olsen, Kristina ; Hedley, Paula L. ; Hagen, Christian M. ; Rode, Line ; Placing, Sophie ; Wøjdemann, Karen R. ; Shalmi, Anne Cathrine ; Sundberg, Karin ; Nørremølle, Anne ; Tabor, Ann ; Elson, Joanna L. ; Christiansen, Michael. / The significance of mitochondrial haplogroups in preeclampsia risk. I: Pregnancy Hypertension. 2023 ; Bind 34. s. 146-151.

Bibtex

@article{7d0a52bc94d54f94ae7f384f52b4fb39,
title = "The significance of mitochondrial haplogroups in preeclampsia risk",
abstract = "Objective: To determine whether mitochondrial haplogroups function as disease-modifiers or as susceptibility factors in preeclampsia using a traditional haplogroup association model. Methods: This retrospective study haplotyped 235 control and 78 preeclamptic pregnancies from Denmark using either real-time PCR or Sanger sequencing depending on the rarity of the haplogroup. Results: No significant association between haplogroups and the risk of preeclampsia was found, nor was any role for haplogroups in disease severity uncovered. Conclusion: Mitochondrial haplogroups are not associated with preeclampsia or the severity of preeclampsia in the Danish population. However, this study cannot exclude a role for less common mtDNA variation. Models that can examine these should be applied in preeclamptic patients.",
keywords = "Mitochondrial DNA, Mitochondrial haplogroups, Preeclampsia, Pregnancy",
author = "{Wendelboe Olsen}, Kristina and Hedley, {Paula L.} and Hagen, {Christian M.} and Line Rode and Sophie Placing and W{\o}jdemann, {Karen R.} and Shalmi, {Anne Cathrine} and Karin Sundberg and Anne N{\o}rrem{\o}lle and Ann Tabor and Elson, {Joanna L.} and Michael Christiansen",
note = "Publisher Copyright: {\textcopyright} 2023 The Authors",
year = "2023",
doi = "10.1016/j.preghy.2023.11.001",
language = "English",
volume = "34",
pages = "146--151",
journal = "Pregnancy Hypertension",
issn = "2210-7789",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - The significance of mitochondrial haplogroups in preeclampsia risk

AU - Wendelboe Olsen, Kristina

AU - Hedley, Paula L.

AU - Hagen, Christian M.

AU - Rode, Line

AU - Placing, Sophie

AU - Wøjdemann, Karen R.

AU - Shalmi, Anne Cathrine

AU - Sundberg, Karin

AU - Nørremølle, Anne

AU - Tabor, Ann

AU - Elson, Joanna L.

AU - Christiansen, Michael

N1 - Publisher Copyright: © 2023 The Authors

PY - 2023

Y1 - 2023

N2 - Objective: To determine whether mitochondrial haplogroups function as disease-modifiers or as susceptibility factors in preeclampsia using a traditional haplogroup association model. Methods: This retrospective study haplotyped 235 control and 78 preeclamptic pregnancies from Denmark using either real-time PCR or Sanger sequencing depending on the rarity of the haplogroup. Results: No significant association between haplogroups and the risk of preeclampsia was found, nor was any role for haplogroups in disease severity uncovered. Conclusion: Mitochondrial haplogroups are not associated with preeclampsia or the severity of preeclampsia in the Danish population. However, this study cannot exclude a role for less common mtDNA variation. Models that can examine these should be applied in preeclamptic patients.

AB - Objective: To determine whether mitochondrial haplogroups function as disease-modifiers or as susceptibility factors in preeclampsia using a traditional haplogroup association model. Methods: This retrospective study haplotyped 235 control and 78 preeclamptic pregnancies from Denmark using either real-time PCR or Sanger sequencing depending on the rarity of the haplogroup. Results: No significant association between haplogroups and the risk of preeclampsia was found, nor was any role for haplogroups in disease severity uncovered. Conclusion: Mitochondrial haplogroups are not associated with preeclampsia or the severity of preeclampsia in the Danish population. However, this study cannot exclude a role for less common mtDNA variation. Models that can examine these should be applied in preeclamptic patients.

KW - Mitochondrial DNA

KW - Mitochondrial haplogroups

KW - Preeclampsia

KW - Pregnancy

U2 - 10.1016/j.preghy.2023.11.001

DO - 10.1016/j.preghy.2023.11.001

M3 - Journal article

C2 - 37979242

AN - SCOPUS:85177201744

VL - 34

SP - 146

EP - 151

JO - Pregnancy Hypertension

JF - Pregnancy Hypertension

SN - 2210-7789

ER -

ID: 374404566