The Mantle Cell Lymphoma International Prognostic Index (MIPI) is superior to the International Prognostic Index (IPI) in predicting survival following intensive first-line immunochemotherapy and autologous stem cell transplantation (ASCT)

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Christian H Geisler
  • Arne Kolstad
  • Anna Laurell
  • Riikka Räty
  • Mats Jerkeman
  • Mikael Eriksson
  • Marie Nordström
  • Eva Kimby
  • Anne Marie Boesen
  • Herman Nilsson-Ehle
  • Outi Kuittinen
  • Grete F Lauritzsen
  • Elisabeth Ralfkiaer
  • Mats Ehinger
  • Christer Sundström
  • Jan Delabie
  • Marja-Liisa Karjalainen-Lindsberg
  • Brown, Peter de Nully
  • Erkki Elonen
  • Nordic Lymphoma Group
Mantle cell lymphoma (MCL) has a heterogeneous clinical course. The recently proposed Mantle Cell Lymphoma International Prognostic Index (MIPI) predicted the survival of MCL better than the International Prognostic Index in MCL patients treated with conventional chemotherapy, but its validity in MCL treated with more intensive immunochemotherapy has been questioned. Applied here to 158 patients of the Nordic MCL2 trial of first-line intensive immunochemotherapy followed by high-dose chemotherapy and autologous stem cell transplantation, the MIPI and the simplified MIPI (s-MIPI) predicted survival significantly better (P <.001) than the International Prognostic Index (P > .004). Both the MIPI and the s-MIPI mainly identified 2 risk groups, low and intermediate versus high risk, with the more easily applied s-MIPI being just as powerful as the MIPI. The MIPI(B) (biological), incorporating Ki-67 expression, identified almost half of the patients as high risk. We suggest that also a simplified MIPI(B) is feasible.
OriginalsprogEngelsk
TidsskriftBlood
Vol/bind115
Udgave nummer8
Sider (fra-til)1530-3
Antal sider4
ISSN0006-4971
DOI
StatusUdgivet - 25 feb. 2010

ID: 34128047