Clonal haematopoiesis of indeterminate potential and impaired kidney function—A Danish general population study with 11 years follow-up

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Clonal haematopoiesis of indeterminate potential and impaired kidney function—A Danish general population study with 11 years follow-up. / Larsen, Morten K.; Skov, Vibe; Kjær, Lasse; Møller-Palacino, Natascha A.; Pedersen, Rasmus K.; Andersen, Morten; Ottesen, Johnny T.; Cordua, Sabrina; Poulsen, Henrik E.; Dahl, Morten; Knudsen, Trine A.; Eickhardt-Dalbøge, Christina Schjellerup; Koschmieder, Steffen; Pedersen, Kasper M.; Çolak, Yunus; Bojesen, Stig E.; Nordestgaard, Børge G.; Stiehl, Thomas; Hasselbalch, Hans C.; Ellervik, Christina.

I: European Journal of Haematology, Bind 109, Nr. 5, 2022, s. 576-585.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Larsen, MK, Skov, V, Kjær, L, Møller-Palacino, NA, Pedersen, RK, Andersen, M, Ottesen, JT, Cordua, S, Poulsen, HE, Dahl, M, Knudsen, TA, Eickhardt-Dalbøge, CS, Koschmieder, S, Pedersen, KM, Çolak, Y, Bojesen, SE, Nordestgaard, BG, Stiehl, T, Hasselbalch, HC & Ellervik, C 2022, 'Clonal haematopoiesis of indeterminate potential and impaired kidney function—A Danish general population study with 11 years follow-up', European Journal of Haematology, bind 109, nr. 5, s. 576-585. https://doi.org/10.1111/ejh.13845

APA

Larsen, M. K., Skov, V., Kjær, L., Møller-Palacino, N. A., Pedersen, R. K., Andersen, M., Ottesen, J. T., Cordua, S., Poulsen, H. E., Dahl, M., Knudsen, T. A., Eickhardt-Dalbøge, C. S., Koschmieder, S., Pedersen, K. M., Çolak, Y., Bojesen, S. E., Nordestgaard, B. G., Stiehl, T., Hasselbalch, H. C., & Ellervik, C. (2022). Clonal haematopoiesis of indeterminate potential and impaired kidney function—A Danish general population study with 11 years follow-up. European Journal of Haematology, 109(5), 576-585. https://doi.org/10.1111/ejh.13845

Vancouver

Larsen MK, Skov V, Kjær L, Møller-Palacino NA, Pedersen RK, Andersen M o.a. Clonal haematopoiesis of indeterminate potential and impaired kidney function—A Danish general population study with 11 years follow-up. European Journal of Haematology. 2022;109(5):576-585. https://doi.org/10.1111/ejh.13845

Author

Larsen, Morten K. ; Skov, Vibe ; Kjær, Lasse ; Møller-Palacino, Natascha A. ; Pedersen, Rasmus K. ; Andersen, Morten ; Ottesen, Johnny T. ; Cordua, Sabrina ; Poulsen, Henrik E. ; Dahl, Morten ; Knudsen, Trine A. ; Eickhardt-Dalbøge, Christina Schjellerup ; Koschmieder, Steffen ; Pedersen, Kasper M. ; Çolak, Yunus ; Bojesen, Stig E. ; Nordestgaard, Børge G. ; Stiehl, Thomas ; Hasselbalch, Hans C. ; Ellervik, Christina. / Clonal haematopoiesis of indeterminate potential and impaired kidney function—A Danish general population study with 11 years follow-up. I: European Journal of Haematology. 2022 ; Bind 109, Nr. 5. s. 576-585.

Bibtex

@article{15c1d4d47b83492f8342285edd345be9,

title = "Clonal haematopoiesis of indeterminate potential and impaired kidney function—A Danish general population study with 11 years follow-up",

abstract = "The myeloproliferative neoplasms are associated with chronic kidney disease but whether clonal haematopoiesis of indeterminate potential (CHIP) is associated with impaired kidney function is unknown. In the Danish General Suburban Population Study (N = 19 958) from 2010 to 2013, 645 individuals were positive for JAK2V617F (N = 613) or CALR (N = 32) mutations. Mutation-positive individuals without haematological malignancy were defined as having CHIP (N = 629). We used multiple and inverse probability weighted (IPW)-adjusted linear regression analysis to estimate adjusted mean (95% confidence interval) differences in estimated glomerular filtration rate (eGFR; ml/min/1.73 m2) by mutation status, variant allele frequency (VAF%), blood cell counts, and neutrophil-to-lymphocyte ratio (NLR). We performed 11-year longitudinal follow-up of eGFR in all individuals. Compared to CHIP-negative individuals, the mean differences in eGFR were −5.6 (−10.3, −0.8, p =.02) for CALR, −11.9 (−21.4, −2.4, p = 0.01) for CALR type 2, and −10.1 (−18.1, −2.2, p =.01) for CALR with VAF ≥ 1%. The IPW-adjusted linear regression analyses showed similar results. NLR was negatively associated with eGFR. Individuals with CALR type 2 had a worse 11-year longitudinal follow-up on eGFR compared to CHIP-negative individuals (p =.004). In conclusion, individuals with CALR mutations, especially CALR type 2, had impaired kidney function compared to CHIP-negative individuals as measured by a lower eGFR at baseline and during 11-year follow-up.",

keywords = "CALR, CHIP, clonal haematopoiesis of indeterminate potential, eGFR, epidemiology, impaired kidney function, JAK2V617F, population studies",

author = "Larsen, {Morten K.} and Vibe Skov and Lasse Kj{\ae}r and M{\o}ller-Palacino, {Natascha A.} and Pedersen, {Rasmus K.} and Morten Andersen and Ottesen, {Johnny T.} and Sabrina Cordua and Poulsen, {Henrik E.} and Morten Dahl and Knudsen, {Trine A.} and Eickhardt-Dalb{\o}ge, {Christina Schjellerup} and Steffen Koschmieder and Pedersen, {Kasper M.} and Yunus {\c C}olak and Bojesen, {Stig E.} and Nordestgaard, {B{\o}rge G.} and Thomas Stiehl and Hasselbalch, {Hans C.} and Christina Ellervik",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors. European Journal of Haematology published by John Wiley & Sons Ltd.",

year = "2022",

doi = "10.1111/ejh.13845",

language = "English",

volume = "109",

pages = "576--585",

journal = "Scandinavian Journal of Haematology",

issn = "0902-4441",

publisher = "Wiley-Blackwell",

number = "5",

}

RIS

TY - JOUR

T1 - Clonal haematopoiesis of indeterminate potential and impaired kidney function—A Danish general population study with 11 years follow-up

AU - Larsen, Morten K.

AU - Skov, Vibe

AU - Kjær, Lasse

AU - Møller-Palacino, Natascha A.

AU - Pedersen, Rasmus K.

AU - Andersen, Morten

AU - Ottesen, Johnny T.

AU - Cordua, Sabrina

AU - Poulsen, Henrik E.

AU - Dahl, Morten

AU - Knudsen, Trine A.

AU - Eickhardt-Dalbøge, Christina Schjellerup

AU - Koschmieder, Steffen

AU - Pedersen, Kasper M.

AU - Çolak, Yunus

AU - Bojesen, Stig E.

AU - Nordestgaard, Børge G.

AU - Stiehl, Thomas

AU - Hasselbalch, Hans C.

AU - Ellervik, Christina

PY - 2022

Y1 - 2022

N2 - The myeloproliferative neoplasms are associated with chronic kidney disease but whether clonal haematopoiesis of indeterminate potential (CHIP) is associated with impaired kidney function is unknown. In the Danish General Suburban Population Study (N = 19 958) from 2010 to 2013, 645 individuals were positive for JAK2V617F (N = 613) or CALR (N = 32) mutations. Mutation-positive individuals without haematological malignancy were defined as having CHIP (N = 629). We used multiple and inverse probability weighted (IPW)-adjusted linear regression analysis to estimate adjusted mean (95% confidence interval) differences in estimated glomerular filtration rate (eGFR; ml/min/1.73 m2) by mutation status, variant allele frequency (VAF%), blood cell counts, and neutrophil-to-lymphocyte ratio (NLR). We performed 11-year longitudinal follow-up of eGFR in all individuals. Compared to CHIP-negative individuals, the mean differences in eGFR were −5.6 (−10.3, −0.8, p =.02) for CALR, −11.9 (−21.4, −2.4, p = 0.01) for CALR type 2, and −10.1 (−18.1, −2.2, p =.01) for CALR with VAF ≥ 1%. The IPW-adjusted linear regression analyses showed similar results. NLR was negatively associated with eGFR. Individuals with CALR type 2 had a worse 11-year longitudinal follow-up on eGFR compared to CHIP-negative individuals (p =.004). In conclusion, individuals with CALR mutations, especially CALR type 2, had impaired kidney function compared to CHIP-negative individuals as measured by a lower eGFR at baseline and during 11-year follow-up.

AB - The myeloproliferative neoplasms are associated with chronic kidney disease but whether clonal haematopoiesis of indeterminate potential (CHIP) is associated with impaired kidney function is unknown. In the Danish General Suburban Population Study (N = 19 958) from 2010 to 2013, 645 individuals were positive for JAK2V617F (N = 613) or CALR (N = 32) mutations. Mutation-positive individuals without haematological malignancy were defined as having CHIP (N = 629). We used multiple and inverse probability weighted (IPW)-adjusted linear regression analysis to estimate adjusted mean (95% confidence interval) differences in estimated glomerular filtration rate (eGFR; ml/min/1.73 m2) by mutation status, variant allele frequency (VAF%), blood cell counts, and neutrophil-to-lymphocyte ratio (NLR). We performed 11-year longitudinal follow-up of eGFR in all individuals. Compared to CHIP-negative individuals, the mean differences in eGFR were −5.6 (−10.3, −0.8, p =.02) for CALR, −11.9 (−21.4, −2.4, p = 0.01) for CALR type 2, and −10.1 (−18.1, −2.2, p =.01) for CALR with VAF ≥ 1%. The IPW-adjusted linear regression analyses showed similar results. NLR was negatively associated with eGFR. Individuals with CALR type 2 had a worse 11-year longitudinal follow-up on eGFR compared to CHIP-negative individuals (p =.004). In conclusion, individuals with CALR mutations, especially CALR type 2, had impaired kidney function compared to CHIP-negative individuals as measured by a lower eGFR at baseline and during 11-year follow-up.

KW - CALR

KW - CHIP

KW - clonal haematopoiesis of indeterminate potential

KW - eGFR

KW - epidemiology

KW - impaired kidney function

KW - JAK2V617F

KW - population studies

U2 - 10.1111/ejh.13845

DO - 10.1111/ejh.13845

M3 - Journal article

C2 - 36054308

AN - SCOPUS:85136518495

VL - 109

SP - 576

EP - 585

JO - Scandinavian Journal of Haematology

JF - Scandinavian Journal of Haematology

SN - 0902-4441

IS - 5

ER -

ID: 323846765

Institut for Klinisk Medicin