Biomarkers of systemic inflammation, soluble IL-2Rα and the multiple sclerosis-associated IL2RA SNP rs2104286 in healthy subjects and multiple sclerosis patients

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Biomarkers of systemic inflammation, soluble IL-2Rα and the multiple sclerosis-associated IL2RA SNP rs2104286 in healthy subjects and multiple sclerosis patients. / Buhelt, Sophie; Søndergaard, Helle Bach; Mahler, Mie Reith; Cobanovic, Stefan; Börnsen, Lars; Ammitzbøll, Cecilie; Oturai, Annette Bang; Sellebjerg, Finn.

I: Multiple Sclerosis and Related Disorders, Bind 54, 103140, 2021.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Buhelt, S, Søndergaard, HB, Mahler, MR, Cobanovic, S, Börnsen, L, Ammitzbøll, C, Oturai, AB & Sellebjerg, F 2021, 'Biomarkers of systemic inflammation, soluble IL-2Rα and the multiple sclerosis-associated IL2RA SNP rs2104286 in healthy subjects and multiple sclerosis patients', Multiple Sclerosis and Related Disorders, bind 54, 103140. https://doi.org/10.1016/j.msard.2021.103140

APA

Buhelt, S., Søndergaard, H. B., Mahler, M. R., Cobanovic, S., Börnsen, L., Ammitzbøll, C., Oturai, A. B., & Sellebjerg, F. (2021). Biomarkers of systemic inflammation, soluble IL-2Rα and the multiple sclerosis-associated IL2RA SNP rs2104286 in healthy subjects and multiple sclerosis patients. Multiple Sclerosis and Related Disorders, 54, [103140]. https://doi.org/10.1016/j.msard.2021.103140

Vancouver

Buhelt S, Søndergaard HB, Mahler MR, Cobanovic S, Börnsen L, Ammitzbøll C o.a. Biomarkers of systemic inflammation, soluble IL-2Rα and the multiple sclerosis-associated IL2RA SNP rs2104286 in healthy subjects and multiple sclerosis patients. Multiple Sclerosis and Related Disorders. 2021;54. 103140. https://doi.org/10.1016/j.msard.2021.103140

Author

Buhelt, Sophie ; Søndergaard, Helle Bach ; Mahler, Mie Reith ; Cobanovic, Stefan ; Börnsen, Lars ; Ammitzbøll, Cecilie ; Oturai, Annette Bang ; Sellebjerg, Finn. / Biomarkers of systemic inflammation, soluble IL-2Rα and the multiple sclerosis-associated IL2RA SNP rs2104286 in healthy subjects and multiple sclerosis patients. I: Multiple Sclerosis and Related Disorders. 2021 ; Bind 54.

Bibtex

@article{7d0231fae2f14509af6e92e26786099c,
title = "Biomarkers of systemic inflammation, soluble IL-2Rα and the multiple sclerosis-associated IL2RA SNP rs2104286 in healthy subjects and multiple sclerosis patients",
abstract = "Soluble interleukin-2 (IL-2) receptor α (sIL-2Rα) antagonizes IL-2 signaling and is involved in the pathogenesis of several immune-mediated diseases including multiple sclerosis (MS). The level of sIL-2Rα is affected by the MS-associated single nucleotide polymorphism (SNP) rs2104286. By use of ELISA and electrochemiluminescence, we investigated if 26 biomarkers of systemic inflammation were associated with sIL-2Rα and rs2104286 in cohorts of healthy subjects and MS patients in serum and heparin plasma. We found that sIL-2Rα significantly correlated with the level of tumor necrosis factor-α (TNFα) (r = 0.391, p = 0.002) in healthy subjects and the association was validated in a separate cohort. Additional, in healthy subjects we confirmed a previous report indicating that C-reactive protein (CRP) correlates with sIL-2Rα (r = 0.278, p = 0.034). None of the biomarkers of systemic inflammation were significantly associated with sIL-2Rα in MS patients. Furthermore, the MS-associated SNP rs2104286 was not significantly associated with any of the biomarkers of systemic inflammation in neither healthy subjects nor MS patients. We conclude that sIL-2Rα is associated with TNFα and CRP in healthy subjects. However, further research is required to confirm the use of sIL-2Rα as biomarker of systemic inflammation as well as to assess the mechanism underlying the observed correlation between levels of sIL-2Rα and TNFα.",
keywords = "CD25, CRP, Multiple sclerosis, rs2104286, sIL-2Rα, Systemic inflammation, TNF",
author = "Sophie Buhelt and S{\o}ndergaard, {Helle Bach} and Mahler, {Mie Reith} and Stefan Cobanovic and Lars B{\"o}rnsen and Cecilie Ammitzb{\o}ll and Oturai, {Annette Bang} and Finn Sellebjerg",
note = "Publisher Copyright: {\textcopyright} 2021",
year = "2021",
doi = "10.1016/j.msard.2021.103140",
language = "English",
volume = "54",
journal = "Multiple Sclerosis and Related Disorders",
issn = "2211-0348",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Biomarkers of systemic inflammation, soluble IL-2Rα and the multiple sclerosis-associated IL2RA SNP rs2104286 in healthy subjects and multiple sclerosis patients

AU - Buhelt, Sophie

AU - Søndergaard, Helle Bach

AU - Mahler, Mie Reith

AU - Cobanovic, Stefan

AU - Börnsen, Lars

AU - Ammitzbøll, Cecilie

AU - Oturai, Annette Bang

AU - Sellebjerg, Finn

N1 - Publisher Copyright: © 2021

PY - 2021

Y1 - 2021

N2 - Soluble interleukin-2 (IL-2) receptor α (sIL-2Rα) antagonizes IL-2 signaling and is involved in the pathogenesis of several immune-mediated diseases including multiple sclerosis (MS). The level of sIL-2Rα is affected by the MS-associated single nucleotide polymorphism (SNP) rs2104286. By use of ELISA and electrochemiluminescence, we investigated if 26 biomarkers of systemic inflammation were associated with sIL-2Rα and rs2104286 in cohorts of healthy subjects and MS patients in serum and heparin plasma. We found that sIL-2Rα significantly correlated with the level of tumor necrosis factor-α (TNFα) (r = 0.391, p = 0.002) in healthy subjects and the association was validated in a separate cohort. Additional, in healthy subjects we confirmed a previous report indicating that C-reactive protein (CRP) correlates with sIL-2Rα (r = 0.278, p = 0.034). None of the biomarkers of systemic inflammation were significantly associated with sIL-2Rα in MS patients. Furthermore, the MS-associated SNP rs2104286 was not significantly associated with any of the biomarkers of systemic inflammation in neither healthy subjects nor MS patients. We conclude that sIL-2Rα is associated with TNFα and CRP in healthy subjects. However, further research is required to confirm the use of sIL-2Rα as biomarker of systemic inflammation as well as to assess the mechanism underlying the observed correlation between levels of sIL-2Rα and TNFα.

AB - Soluble interleukin-2 (IL-2) receptor α (sIL-2Rα) antagonizes IL-2 signaling and is involved in the pathogenesis of several immune-mediated diseases including multiple sclerosis (MS). The level of sIL-2Rα is affected by the MS-associated single nucleotide polymorphism (SNP) rs2104286. By use of ELISA and electrochemiluminescence, we investigated if 26 biomarkers of systemic inflammation were associated with sIL-2Rα and rs2104286 in cohorts of healthy subjects and MS patients in serum and heparin plasma. We found that sIL-2Rα significantly correlated with the level of tumor necrosis factor-α (TNFα) (r = 0.391, p = 0.002) in healthy subjects and the association was validated in a separate cohort. Additional, in healthy subjects we confirmed a previous report indicating that C-reactive protein (CRP) correlates with sIL-2Rα (r = 0.278, p = 0.034). None of the biomarkers of systemic inflammation were significantly associated with sIL-2Rα in MS patients. Furthermore, the MS-associated SNP rs2104286 was not significantly associated with any of the biomarkers of systemic inflammation in neither healthy subjects nor MS patients. We conclude that sIL-2Rα is associated with TNFα and CRP in healthy subjects. However, further research is required to confirm the use of sIL-2Rα as biomarker of systemic inflammation as well as to assess the mechanism underlying the observed correlation between levels of sIL-2Rα and TNFα.

KW - CD25

KW - CRP

KW - Multiple sclerosis

KW - rs2104286

KW - sIL-2Rα

KW - Systemic inflammation

KW - TNF

U2 - 10.1016/j.msard.2021.103140

DO - 10.1016/j.msard.2021.103140

M3 - Journal article

C2 - 34304016

AN - SCOPUS:85111818085

VL - 54

JO - Multiple Sclerosis and Related Disorders

JF - Multiple Sclerosis and Related Disorders

SN - 2211-0348

M1 - 103140

ER -

ID: 276274475