Chemokine CCL2 and chemokine receptor CCR2 in early active multiple sclerosis

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Standard

Chemokine CCL2 and chemokine receptor CCR2 in early active multiple sclerosis. / Sørensen, Torben Lykke; Ransohoff, R M; Strieter, R M; Sellebjerg, F.

I: European journal of neurology : the official journal of the European Federation of Neurological Societies, Bind 11, Nr. 7, 07.2004, s. 445-9.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning

Harvard

Sørensen, TL, Ransohoff, RM, Strieter, RM & Sellebjerg, F 2004, 'Chemokine CCL2 and chemokine receptor CCR2 in early active multiple sclerosis', European journal of neurology : the official journal of the European Federation of Neurological Societies, bind 11, nr. 7, s. 445-9. https://doi.org/10.1111/j.1468-1331.2004.00796.x

APA

Sørensen, T. L., Ransohoff, R. M., Strieter, R. M., & Sellebjerg, F. (2004). Chemokine CCL2 and chemokine receptor CCR2 in early active multiple sclerosis. European journal of neurology : the official journal of the European Federation of Neurological Societies, 11(7), 445-9. https://doi.org/10.1111/j.1468-1331.2004.00796.x

Vancouver

Sørensen TL, Ransohoff RM, Strieter RM, Sellebjerg F. Chemokine CCL2 and chemokine receptor CCR2 in early active multiple sclerosis. European journal of neurology : the official journal of the European Federation of Neurological Societies. 2004 jul.;11(7):445-9. https://doi.org/10.1111/j.1468-1331.2004.00796.x

Author

Sørensen, Torben Lykke ; Ransohoff, R M ; Strieter, R M ; Sellebjerg, F. / Chemokine CCL2 and chemokine receptor CCR2 in early active multiple sclerosis. I: European journal of neurology : the official journal of the European Federation of Neurological Societies. 2004 ; Bind 11, Nr. 7. s. 445-9.

Bibtex

@article{a1ed08d8adef490ca0cef9ce19a58351,
title = "Chemokine CCL2 and chemokine receptor CCR2 in early active multiple sclerosis",
abstract = "The chemokine monocyte chemoattractant protein (MCP)-1/CCL2 and its receptor CCR2 have been strongly implicated in disease pathogenesis in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis (MS), whereas data on the CCL2-CCR2 axis are scarce in MS. We studied the expression of CCR2 on leukocytes in blood and cerebrospinal fluid (CSF) from patients with monosymptomatic optic neuritis and MS, and the concentration of CCL2 in the CSF from these patients. Results were compared with the results in non-inflammatory neurological controls and were correlated with other parameters (magnetic resonance imaging and CSF data). Our findings suggest a limited role for CCL2/CCR2 in early active MS.",
keywords = "Adult, Cerebrospinal Fluid, Chemokine CCL2, Female, Humans, Male, Middle Aged, Monocytes, Multiple Sclerosis, Receptors, CCR2, Receptors, Chemokine, T-Lymphocytes",
author = "S{\o}rensen, {Torben Lykke} and Ransohoff, {R M} and Strieter, {R M} and F Sellebjerg",
year = "2004",
month = jul,
doi = "10.1111/j.1468-1331.2004.00796.x",
language = "English",
volume = "11",
pages = "445--9",
journal = "European Journal of Neurology",
issn = "1351-5101",
publisher = "Wiley-Blackwell",
number = "7",

}

RIS

TY - JOUR

T1 - Chemokine CCL2 and chemokine receptor CCR2 in early active multiple sclerosis

AU - Sørensen, Torben Lykke

AU - Ransohoff, R M

AU - Strieter, R M

AU - Sellebjerg, F

PY - 2004/7

Y1 - 2004/7

N2 - The chemokine monocyte chemoattractant protein (MCP)-1/CCL2 and its receptor CCR2 have been strongly implicated in disease pathogenesis in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis (MS), whereas data on the CCL2-CCR2 axis are scarce in MS. We studied the expression of CCR2 on leukocytes in blood and cerebrospinal fluid (CSF) from patients with monosymptomatic optic neuritis and MS, and the concentration of CCL2 in the CSF from these patients. Results were compared with the results in non-inflammatory neurological controls and were correlated with other parameters (magnetic resonance imaging and CSF data). Our findings suggest a limited role for CCL2/CCR2 in early active MS.

AB - The chemokine monocyte chemoattractant protein (MCP)-1/CCL2 and its receptor CCR2 have been strongly implicated in disease pathogenesis in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis (MS), whereas data on the CCL2-CCR2 axis are scarce in MS. We studied the expression of CCR2 on leukocytes in blood and cerebrospinal fluid (CSF) from patients with monosymptomatic optic neuritis and MS, and the concentration of CCL2 in the CSF from these patients. Results were compared with the results in non-inflammatory neurological controls and were correlated with other parameters (magnetic resonance imaging and CSF data). Our findings suggest a limited role for CCL2/CCR2 in early active MS.

KW - Adult

KW - Cerebrospinal Fluid

KW - Chemokine CCL2

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Monocytes

KW - Multiple Sclerosis

KW - Receptors, CCR2

KW - Receptors, Chemokine

KW - T-Lymphocytes

U2 - 10.1111/j.1468-1331.2004.00796.x

DO - 10.1111/j.1468-1331.2004.00796.x

M3 - Journal article

C2 - 15257681

VL - 11

SP - 445

EP - 449

JO - European Journal of Neurology

JF - European Journal of Neurology

SN - 1351-5101

IS - 7

ER -

ID: 111409749