CLIPPERS among patients diagnosed with non-specific CNS neuroinflammatory diseases

Publikation: Bidrag til tidsskriftLetterfagfællebedømt

Standard

CLIPPERS among patients diagnosed with non-specific CNS neuroinflammatory diseases. / Kerrn-Jespersen, B M; Lindelof, Mette; Illes, Zsolt; Blaabjerg, Morten; Lund, E L; Klausen, Camilla; Christiansen, Ingelise; Sellebjerg, F; Kondziella, D.

I: Journal of the Neurological Sciences, Bind 343, Nr. 1-2, 08.2014, s. 224-227.

Publikation: Bidrag til tidsskriftLetterfagfællebedømt

Harvard

Kerrn-Jespersen, BM, Lindelof, M, Illes, Z, Blaabjerg, M, Lund, EL, Klausen, C, Christiansen, I, Sellebjerg, F & Kondziella, D 2014, 'CLIPPERS among patients diagnosed with non-specific CNS neuroinflammatory diseases', Journal of the Neurological Sciences, bind 343, nr. 1-2, s. 224-227. https://doi.org/10.1016/j.jns.2014.06.002

APA

Kerrn-Jespersen, B. M., Lindelof, M., Illes, Z., Blaabjerg, M., Lund, E. L., Klausen, C., Christiansen, I., Sellebjerg, F., & Kondziella, D. (2014). CLIPPERS among patients diagnosed with non-specific CNS neuroinflammatory diseases. Journal of the Neurological Sciences, 343(1-2), 224-227. https://doi.org/10.1016/j.jns.2014.06.002

Vancouver

Kerrn-Jespersen BM, Lindelof M, Illes Z, Blaabjerg M, Lund EL, Klausen C o.a. CLIPPERS among patients diagnosed with non-specific CNS neuroinflammatory diseases. Journal of the Neurological Sciences. 2014 aug.;343(1-2):224-227. https://doi.org/10.1016/j.jns.2014.06.002

Author

Kerrn-Jespersen, B M ; Lindelof, Mette ; Illes, Zsolt ; Blaabjerg, Morten ; Lund, E L ; Klausen, Camilla ; Christiansen, Ingelise ; Sellebjerg, F ; Kondziella, D. / CLIPPERS among patients diagnosed with non-specific CNS neuroinflammatory diseases. I: Journal of the Neurological Sciences. 2014 ; Bind 343, Nr. 1-2. s. 224-227.

Bibtex

@article{8bad18dd69d64455b49bf1f58998e215,
title = "CLIPPERS among patients diagnosed with non-specific CNS neuroinflammatory diseases",
abstract = "Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS) is an inflammatory CNS disorder characterized by 1) subacute onset of cerebellar and brainstem symptoms, 2) peripontine contrast-enhancing perivascular lesions with a {"}salt-and-pepper{"} appearance on MRI, and 3) angiocentric, predominantly T-lymphocytic infiltration as revealed by brain biopsy. Inflammatory diseases including neuroinfections, CNS lymphoma and neurosarcoidosis must be excluded. Since CLIPPERS was described in 2010, many patients might have been misdiagnosed in the past. We therefore searched medical records from a large tertiary neurological center, the Department of Neurology at Rigshospitalet, Copenhagen University Hospital, for patients discharged between 1999 and 2013 with a diagnosis of {"}sarcoidosis with other localization{"}, {"}other acute disseminating demyelination{"}, {"}other demyelinating disease in the CNS{"} or {"}encephalitis, myelitis or encephalomyelitis{"}. Of 206 identified patients, 24 had been examined by brain biopsy and were included for further evaluation. Following clinical, neuroradiological and neuropathological review, 3 patients (12.5%) were reclassified as having CLIPPERS. Median long-term follow-up was 75 months. The present results suggest that clinical re-evaluation of patients previously diagnosed with unspecified inflammatory demyelinating CNS disease or atypical neurosarcoidosis may increase the detection rate of CLIPPERS. Further, potentially severe neurological deficits and progressive parenchymal atrophy on MRI may suggest neurodegenerative features, which emphasizes the need for early immunomodulatory treatment.",
keywords = "Adult, Antigens, CD3, Brain, Central Nervous System Diseases, Female, Humans, Inflammation, Magnetic Resonance Imaging, Male, Middle Aged, Retrospective Studies, Spinal Cord, Steroids, Young Adult",
author = "Kerrn-Jespersen, {B M} and Mette Lindelof and Zsolt Illes and Morten Blaabjerg and Lund, {E L} and Camilla Klausen and Ingelise Christiansen and F Sellebjerg and D Kondziella",
note = "Copyright {\textcopyright} 2014 Elsevier B.V. All rights reserved.",
year = "2014",
month = aug,
doi = "10.1016/j.jns.2014.06.002",
language = "English",
volume = "343",
pages = "224--227",
journal = "Journal of the Neurological Sciences",
issn = "0022-510X",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - CLIPPERS among patients diagnosed with non-specific CNS neuroinflammatory diseases

AU - Kerrn-Jespersen, B M

AU - Lindelof, Mette

AU - Illes, Zsolt

AU - Blaabjerg, Morten

AU - Lund, E L

AU - Klausen, Camilla

AU - Christiansen, Ingelise

AU - Sellebjerg, F

AU - Kondziella, D

N1 - Copyright © 2014 Elsevier B.V. All rights reserved.

PY - 2014/8

Y1 - 2014/8

N2 - Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS) is an inflammatory CNS disorder characterized by 1) subacute onset of cerebellar and brainstem symptoms, 2) peripontine contrast-enhancing perivascular lesions with a "salt-and-pepper" appearance on MRI, and 3) angiocentric, predominantly T-lymphocytic infiltration as revealed by brain biopsy. Inflammatory diseases including neuroinfections, CNS lymphoma and neurosarcoidosis must be excluded. Since CLIPPERS was described in 2010, many patients might have been misdiagnosed in the past. We therefore searched medical records from a large tertiary neurological center, the Department of Neurology at Rigshospitalet, Copenhagen University Hospital, for patients discharged between 1999 and 2013 with a diagnosis of "sarcoidosis with other localization", "other acute disseminating demyelination", "other demyelinating disease in the CNS" or "encephalitis, myelitis or encephalomyelitis". Of 206 identified patients, 24 had been examined by brain biopsy and were included for further evaluation. Following clinical, neuroradiological and neuropathological review, 3 patients (12.5%) were reclassified as having CLIPPERS. Median long-term follow-up was 75 months. The present results suggest that clinical re-evaluation of patients previously diagnosed with unspecified inflammatory demyelinating CNS disease or atypical neurosarcoidosis may increase the detection rate of CLIPPERS. Further, potentially severe neurological deficits and progressive parenchymal atrophy on MRI may suggest neurodegenerative features, which emphasizes the need for early immunomodulatory treatment.

AB - Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS) is an inflammatory CNS disorder characterized by 1) subacute onset of cerebellar and brainstem symptoms, 2) peripontine contrast-enhancing perivascular lesions with a "salt-and-pepper" appearance on MRI, and 3) angiocentric, predominantly T-lymphocytic infiltration as revealed by brain biopsy. Inflammatory diseases including neuroinfections, CNS lymphoma and neurosarcoidosis must be excluded. Since CLIPPERS was described in 2010, many patients might have been misdiagnosed in the past. We therefore searched medical records from a large tertiary neurological center, the Department of Neurology at Rigshospitalet, Copenhagen University Hospital, for patients discharged between 1999 and 2013 with a diagnosis of "sarcoidosis with other localization", "other acute disseminating demyelination", "other demyelinating disease in the CNS" or "encephalitis, myelitis or encephalomyelitis". Of 206 identified patients, 24 had been examined by brain biopsy and were included for further evaluation. Following clinical, neuroradiological and neuropathological review, 3 patients (12.5%) were reclassified as having CLIPPERS. Median long-term follow-up was 75 months. The present results suggest that clinical re-evaluation of patients previously diagnosed with unspecified inflammatory demyelinating CNS disease or atypical neurosarcoidosis may increase the detection rate of CLIPPERS. Further, potentially severe neurological deficits and progressive parenchymal atrophy on MRI may suggest neurodegenerative features, which emphasizes the need for early immunomodulatory treatment.

KW - Adult

KW - Antigens, CD3

KW - Brain

KW - Central Nervous System Diseases

KW - Female

KW - Humans

KW - Inflammation

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Retrospective Studies

KW - Spinal Cord

KW - Steroids

KW - Young Adult

U2 - 10.1016/j.jns.2014.06.002

DO - 10.1016/j.jns.2014.06.002

M3 - Letter

C2 - 24954086

VL - 343

SP - 224

EP - 227

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

SN - 0022-510X

IS - 1-2

ER -

ID: 138175757