CSF inflammation and axonal damage are increased and correlate in progressive multiple sclerosis

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Standard

CSF inflammation and axonal damage are increased and correlate in progressive multiple sclerosis. / Romme Christensen, Jeppe; Börnsen, Lars; Khademi, Mohsen; Olsson, Tomas; Jensen, Poul Erik; Sørensen, Per Soelberg; Sellebjerg, Finn.

I: Multiple Sclerosis, 2013.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Romme Christensen, J, Börnsen, L, Khademi, M, Olsson, T, Jensen, PE, Sørensen, PS & Sellebjerg, F 2013, 'CSF inflammation and axonal damage are increased and correlate in progressive multiple sclerosis', Multiple Sclerosis. https://doi.org/10.1177/1352458512466929

APA

Romme Christensen, J., Börnsen, L., Khademi, M., Olsson, T., Jensen, P. E., Sørensen, P. S., & Sellebjerg, F. (2013). CSF inflammation and axonal damage are increased and correlate in progressive multiple sclerosis. Multiple Sclerosis. https://doi.org/10.1177/1352458512466929

Vancouver

Romme Christensen J, Börnsen L, Khademi M, Olsson T, Jensen PE, Sørensen PS o.a. CSF inflammation and axonal damage are increased and correlate in progressive multiple sclerosis. Multiple Sclerosis. 2013. https://doi.org/10.1177/1352458512466929

Author

Romme Christensen, Jeppe ; Börnsen, Lars ; Khademi, Mohsen ; Olsson, Tomas ; Jensen, Poul Erik ; Sørensen, Per Soelberg ; Sellebjerg, Finn. / CSF inflammation and axonal damage are increased and correlate in progressive multiple sclerosis. I: Multiple Sclerosis. 2013.

Bibtex

@article{e8936cff79054f66a2ab24a0c4c05799,
title = "CSF inflammation and axonal damage are increased and correlate in progressive multiple sclerosis",
abstract = "BACKGROUND: The mechanism underlying disease progression in progressive multiple sclerosis (MS) is uncertain. Pathological studies found widespread inflammation in progressive MS brains correlating with disease progression and axonal damage. OBJECTIVES: To study cerebrospinal fluid (CSF) biomarkers and clarify whether inflammation and axonal damage are associated in progressive MS. METHODS: Using enzyme-linked immunosorbent assay (ELISA), we analysed CSF from 40 secondary progressive (SPMS), 21 primary progressive (PPMS), and 36 relapsing-remitting (RRMS) and 20 non-inflammatory neurological disease (NIND) patients. Twenty-two of the SPMS patients participated in an MBP8298 peptide clinical trial and had CSF follow-up after one year. RESULTS: Compared to NIND patients, inflammatory biomarkers osteopontin and matrix metalloproteinase-9 (MMP9) were increased in all MS patients while CXCL13 was increased in RRMS and SPMS patients. Biomarkers of axonal damage (NFL) and demyelination (MBP) were increased in all MS patients. In progressive MS patients CSF levels of osteopontin and CXCL13 correlated with NFL while osteopontin and MMP9 correlated with MBP. MBP8298 treatment did not affect the levels of the biomarkers after one year of treatment. All biomarkers were continuously increased after one year of follow-up except MBP, which decreased. CONCLUSION: CSF biomarkers of inflammation, axonal damage and demyelination are continuously increased in progressive MS patients and correlate. These findings parallel pathology studies, emphasise a relationship between inflammation, axonal damage and demyelination and support the use of CSF biomarkers in progressive MS clinical trials.",
author = "{Romme Christensen}, Jeppe and Lars B{\"o}rnsen and Mohsen Khademi and Tomas Olsson and Jensen, {Poul Erik} and S{\o}rensen, {Per Soelberg} and Finn Sellebjerg",
year = "2013",
doi = "10.1177/1352458512466929",
language = "English",
journal = "Multiple Sclerosis Journal",
issn = "1352-4585",
publisher = "SAGE Publications",

}

RIS

TY - JOUR

T1 - CSF inflammation and axonal damage are increased and correlate in progressive multiple sclerosis

AU - Romme Christensen, Jeppe

AU - Börnsen, Lars

AU - Khademi, Mohsen

AU - Olsson, Tomas

AU - Jensen, Poul Erik

AU - Sørensen, Per Soelberg

AU - Sellebjerg, Finn

PY - 2013

Y1 - 2013

N2 - BACKGROUND: The mechanism underlying disease progression in progressive multiple sclerosis (MS) is uncertain. Pathological studies found widespread inflammation in progressive MS brains correlating with disease progression and axonal damage. OBJECTIVES: To study cerebrospinal fluid (CSF) biomarkers and clarify whether inflammation and axonal damage are associated in progressive MS. METHODS: Using enzyme-linked immunosorbent assay (ELISA), we analysed CSF from 40 secondary progressive (SPMS), 21 primary progressive (PPMS), and 36 relapsing-remitting (RRMS) and 20 non-inflammatory neurological disease (NIND) patients. Twenty-two of the SPMS patients participated in an MBP8298 peptide clinical trial and had CSF follow-up after one year. RESULTS: Compared to NIND patients, inflammatory biomarkers osteopontin and matrix metalloproteinase-9 (MMP9) were increased in all MS patients while CXCL13 was increased in RRMS and SPMS patients. Biomarkers of axonal damage (NFL) and demyelination (MBP) were increased in all MS patients. In progressive MS patients CSF levels of osteopontin and CXCL13 correlated with NFL while osteopontin and MMP9 correlated with MBP. MBP8298 treatment did not affect the levels of the biomarkers after one year of treatment. All biomarkers were continuously increased after one year of follow-up except MBP, which decreased. CONCLUSION: CSF biomarkers of inflammation, axonal damage and demyelination are continuously increased in progressive MS patients and correlate. These findings parallel pathology studies, emphasise a relationship between inflammation, axonal damage and demyelination and support the use of CSF biomarkers in progressive MS clinical trials.

AB - BACKGROUND: The mechanism underlying disease progression in progressive multiple sclerosis (MS) is uncertain. Pathological studies found widespread inflammation in progressive MS brains correlating with disease progression and axonal damage. OBJECTIVES: To study cerebrospinal fluid (CSF) biomarkers and clarify whether inflammation and axonal damage are associated in progressive MS. METHODS: Using enzyme-linked immunosorbent assay (ELISA), we analysed CSF from 40 secondary progressive (SPMS), 21 primary progressive (PPMS), and 36 relapsing-remitting (RRMS) and 20 non-inflammatory neurological disease (NIND) patients. Twenty-two of the SPMS patients participated in an MBP8298 peptide clinical trial and had CSF follow-up after one year. RESULTS: Compared to NIND patients, inflammatory biomarkers osteopontin and matrix metalloproteinase-9 (MMP9) were increased in all MS patients while CXCL13 was increased in RRMS and SPMS patients. Biomarkers of axonal damage (NFL) and demyelination (MBP) were increased in all MS patients. In progressive MS patients CSF levels of osteopontin and CXCL13 correlated with NFL while osteopontin and MMP9 correlated with MBP. MBP8298 treatment did not affect the levels of the biomarkers after one year of treatment. All biomarkers were continuously increased after one year of follow-up except MBP, which decreased. CONCLUSION: CSF biomarkers of inflammation, axonal damage and demyelination are continuously increased in progressive MS patients and correlate. These findings parallel pathology studies, emphasise a relationship between inflammation, axonal damage and demyelination and support the use of CSF biomarkers in progressive MS clinical trials.

U2 - 10.1177/1352458512466929

DO - 10.1177/1352458512466929

M3 - Journal article

C2 - 23178691

JO - Multiple Sclerosis Journal

JF - Multiple Sclerosis Journal

SN - 1352-4585

ER -

ID: 48569399