Ear-EEG detects ictal and interictal abnormalities in focal and generalized epilepsy: A comparison with scalp EEG monitoring
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Ear-EEG detects ictal and interictal abnormalities in focal and generalized epilepsy : A comparison with scalp EEG monitoring. / Zibrandtsen, I. C.; Kidmose, P.; Christensen, C. B.; Kjaer, T. W.
I: Clinical Neurophysiology, Bind 128, Nr. 12, 2017, s. 2454-2461.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt
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TY - JOUR
T1 - Ear-EEG detects ictal and interictal abnormalities in focal and generalized epilepsy
T2 - A comparison with scalp EEG monitoring
AU - Zibrandtsen, I. C.
AU - Kidmose, P.
AU - Christensen, C. B.
AU - Kjaer, T. W.
PY - 2017
Y1 - 2017
N2 - Objective Ear-EEG is recording of electroencephalography from a small device in the ear. This is the first study to compare ictal and interictal abnormalities recorded with ear-EEG and simultaneous scalp-EEG in an epilepsy monitoring unit. Methods We recorded and compared simultaneous ear-EEG and scalp-EEG from 15 patients with suspected temporal lobe epilepsy. EEGs were compared visually by independent neurophysiologists. Correlation and time-frequency analysis was used to quantify the similarity between ear and scalp electrodes. Spike-averages were used to assess similarity of interictal spikes. Results There were no differences in sensitivity or specificity for seizure detection. Mean correlation coefficient between ear-EEG and nearest scalp electrode was above 0.6 with a statistically significant decreasing trend with increasing distance away from the ear. Ictal morphology and frequency dynamics can be observed from visual inspection and time-frequency analysis. Spike averages derived from ear-EEG electrodes yield a recognizable spike appearance. Conclusions Our results suggest that ear-EEG can reliably detect electroencephalographic patterns associated with focal temporal lobe seizures. Interictal spike morphology from sufficiently large temporal spike sources can be sampled using ear-EEG. Significance Ear-EEG is likely to become an important tool in clinical epilepsy monitoring and diagnosis.
AB - Objective Ear-EEG is recording of electroencephalography from a small device in the ear. This is the first study to compare ictal and interictal abnormalities recorded with ear-EEG and simultaneous scalp-EEG in an epilepsy monitoring unit. Methods We recorded and compared simultaneous ear-EEG and scalp-EEG from 15 patients with suspected temporal lobe epilepsy. EEGs were compared visually by independent neurophysiologists. Correlation and time-frequency analysis was used to quantify the similarity between ear and scalp electrodes. Spike-averages were used to assess similarity of interictal spikes. Results There were no differences in sensitivity or specificity for seizure detection. Mean correlation coefficient between ear-EEG and nearest scalp electrode was above 0.6 with a statistically significant decreasing trend with increasing distance away from the ear. Ictal morphology and frequency dynamics can be observed from visual inspection and time-frequency analysis. Spike averages derived from ear-EEG electrodes yield a recognizable spike appearance. Conclusions Our results suggest that ear-EEG can reliably detect electroencephalographic patterns associated with focal temporal lobe seizures. Interictal spike morphology from sufficiently large temporal spike sources can be sampled using ear-EEG. Significance Ear-EEG is likely to become an important tool in clinical epilepsy monitoring and diagnosis.
KW - Ear-EEG
KW - Long-term monitoring
KW - Mobile EEG
KW - Temporal lobe epilepsy
KW - Ultra-long term monitoring
KW - Wearable EEG
U2 - 10.1016/j.clinph.2017.09.115
DO - 10.1016/j.clinph.2017.09.115
M3 - Journal article
C2 - 29096220
AN - SCOPUS:85032377932
VL - 128
SP - 2454
EP - 2461
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
SN - 1388-2457
IS - 12
ER -
ID: 188486880