Increased cerebrospinal fluid chitinase 3-like 1 and neurofilament light chain in pediatric acquired demyelinating syndromes

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Increased cerebrospinal fluid chitinase 3-like 1 and neurofilament light chain in pediatric acquired demyelinating syndromes. / Boesen, Magnus Spangsberg; Jensen, Poul Erik Hyldgaard; Magyari, Melinda; Born, Alfred Peter; Uldall, Peter Vilhelm; Blinkenberg, Morten; Sellebjerg, Finn.

I: Multiple Sclerosis and Related Disorders, Bind 24, 2018, s. 175-183.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Boesen, MS, Jensen, PEH, Magyari, M, Born, AP, Uldall, PV, Blinkenberg, M & Sellebjerg, F 2018, 'Increased cerebrospinal fluid chitinase 3-like 1 and neurofilament light chain in pediatric acquired demyelinating syndromes', Multiple Sclerosis and Related Disorders, bind 24, s. 175-183. https://doi.org/10.1016/j.msard.2018.05.017

APA

Boesen, M. S., Jensen, P. E. H., Magyari, M., Born, A. P., Uldall, P. V., Blinkenberg, M., & Sellebjerg, F. (2018). Increased cerebrospinal fluid chitinase 3-like 1 and neurofilament light chain in pediatric acquired demyelinating syndromes. Multiple Sclerosis and Related Disorders, 24, 175-183. https://doi.org/10.1016/j.msard.2018.05.017

Vancouver

Boesen MS, Jensen PEH, Magyari M, Born AP, Uldall PV, Blinkenberg M o.a. Increased cerebrospinal fluid chitinase 3-like 1 and neurofilament light chain in pediatric acquired demyelinating syndromes. Multiple Sclerosis and Related Disorders. 2018;24:175-183. https://doi.org/10.1016/j.msard.2018.05.017

Author

Boesen, Magnus Spangsberg ; Jensen, Poul Erik Hyldgaard ; Magyari, Melinda ; Born, Alfred Peter ; Uldall, Peter Vilhelm ; Blinkenberg, Morten ; Sellebjerg, Finn. / Increased cerebrospinal fluid chitinase 3-like 1 and neurofilament light chain in pediatric acquired demyelinating syndromes. I: Multiple Sclerosis and Related Disorders. 2018 ; Bind 24. s. 175-183.

Bibtex

@article{94dcb50ae63d4fe9b6f02f8bd4506c3d,
title = "Increased cerebrospinal fluid chitinase 3-like 1 and neurofilament light chain in pediatric acquired demyelinating syndromes",
abstract = "BACKGROUND: Chitinase 3-like 1 (CHI3L1), neurofilament light chain (NFL) and oligoclonal bands (OCB) in cerebrospinal fluid are associated with central nervous system demyelination in adults. CHI3L1 and OCB are markers of central nervous system inflammation, whereas NFL is a marker of white-matter axonal injury. The aim was to examine whether CHI3L1 and NFL in cerebrospinal fluid are associated with acquired demyelinating syndromes at disease onset in a pediatric population.METHODS: Children (<18 years) referred to hospital for possible neuroinflammatory disease were retrospectively included from 2010 to 2016. Case ascertainment was by review of medical records. NFL and CHI3L1 were measured by enzyme-linked immunosorbent assays. Endpoints were differences in concentrations of cerebrospinal fluid NFL and CHI3L1.RESULTS: We included 193 children who all underwent cerebrospinal fluid OCB examination as part of their diagnostic work-up and classified these children into 5 groups: acquired demyelinating syndromes (n = 33), normal diagnostic work-up (n = 36), inflammatory neurological disease (n = 50), other neurological disease (n = 55), and systemic inflammatory diseases (n = 19). NFL and CHI3L1 in cerebrospinal fluid differed significantly between the five groups (p = 0.0001). CHI3L1 was significantly higher in acquired demyelinating syndromes than in all other groups, and NFL was significantly higher in acquired demyelinating syndromes than in the other groups except systemic inflammatory disease. Children with acute disseminated encephalomyelitis had significantly higher concentrations of CHI3L1 than did children with multiple sclerosis.CONCLUSION: We provide class II evidence that CHI3L1 and NFL are associated with pediatric acquired demyelinating syndromes. CHI3L1 may help distinguishing between acute disseminated encephalomyelitis and multiple sclerosis, but this needs further confirmation.",
keywords = "Adolescent, Biomarkers/cerebrospinal fluid, Child, Child, Preschool, Chitinase-3-Like Protein 1/cerebrospinal fluid, Demyelinating Diseases/cerebrospinal fluid, Female, Humans, Infant, Male, Neurofilament Proteins/cerebrospinal fluid, Oligoclonal Bands/cerebrospinal fluid, Retrospective Studies, Syndrome",
author = "Boesen, {Magnus Spangsberg} and Jensen, {Poul Erik Hyldgaard} and Melinda Magyari and Born, {Alfred Peter} and Uldall, {Peter Vilhelm} and Morten Blinkenberg and Finn Sellebjerg",
note = "Copyright {\circledC} 2018 Elsevier B.V. All rights reserved.",
year = "2018",
doi = "10.1016/j.msard.2018.05.017",
language = "English",
volume = "24",
pages = "175--183",
journal = "Multiple Sclerosis and Related Disorders",
issn = "2211-0348",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Increased cerebrospinal fluid chitinase 3-like 1 and neurofilament light chain in pediatric acquired demyelinating syndromes

AU - Boesen, Magnus Spangsberg

AU - Jensen, Poul Erik Hyldgaard

AU - Magyari, Melinda

AU - Born, Alfred Peter

AU - Uldall, Peter Vilhelm

AU - Blinkenberg, Morten

AU - Sellebjerg, Finn

N1 - Copyright © 2018 Elsevier B.V. All rights reserved.

PY - 2018

Y1 - 2018

N2 - BACKGROUND: Chitinase 3-like 1 (CHI3L1), neurofilament light chain (NFL) and oligoclonal bands (OCB) in cerebrospinal fluid are associated with central nervous system demyelination in adults. CHI3L1 and OCB are markers of central nervous system inflammation, whereas NFL is a marker of white-matter axonal injury. The aim was to examine whether CHI3L1 and NFL in cerebrospinal fluid are associated with acquired demyelinating syndromes at disease onset in a pediatric population.METHODS: Children (<18 years) referred to hospital for possible neuroinflammatory disease were retrospectively included from 2010 to 2016. Case ascertainment was by review of medical records. NFL and CHI3L1 were measured by enzyme-linked immunosorbent assays. Endpoints were differences in concentrations of cerebrospinal fluid NFL and CHI3L1.RESULTS: We included 193 children who all underwent cerebrospinal fluid OCB examination as part of their diagnostic work-up and classified these children into 5 groups: acquired demyelinating syndromes (n = 33), normal diagnostic work-up (n = 36), inflammatory neurological disease (n = 50), other neurological disease (n = 55), and systemic inflammatory diseases (n = 19). NFL and CHI3L1 in cerebrospinal fluid differed significantly between the five groups (p = 0.0001). CHI3L1 was significantly higher in acquired demyelinating syndromes than in all other groups, and NFL was significantly higher in acquired demyelinating syndromes than in the other groups except systemic inflammatory disease. Children with acute disseminated encephalomyelitis had significantly higher concentrations of CHI3L1 than did children with multiple sclerosis.CONCLUSION: We provide class II evidence that CHI3L1 and NFL are associated with pediatric acquired demyelinating syndromes. CHI3L1 may help distinguishing between acute disseminated encephalomyelitis and multiple sclerosis, but this needs further confirmation.

AB - BACKGROUND: Chitinase 3-like 1 (CHI3L1), neurofilament light chain (NFL) and oligoclonal bands (OCB) in cerebrospinal fluid are associated with central nervous system demyelination in adults. CHI3L1 and OCB are markers of central nervous system inflammation, whereas NFL is a marker of white-matter axonal injury. The aim was to examine whether CHI3L1 and NFL in cerebrospinal fluid are associated with acquired demyelinating syndromes at disease onset in a pediatric population.METHODS: Children (<18 years) referred to hospital for possible neuroinflammatory disease were retrospectively included from 2010 to 2016. Case ascertainment was by review of medical records. NFL and CHI3L1 were measured by enzyme-linked immunosorbent assays. Endpoints were differences in concentrations of cerebrospinal fluid NFL and CHI3L1.RESULTS: We included 193 children who all underwent cerebrospinal fluid OCB examination as part of their diagnostic work-up and classified these children into 5 groups: acquired demyelinating syndromes (n = 33), normal diagnostic work-up (n = 36), inflammatory neurological disease (n = 50), other neurological disease (n = 55), and systemic inflammatory diseases (n = 19). NFL and CHI3L1 in cerebrospinal fluid differed significantly between the five groups (p = 0.0001). CHI3L1 was significantly higher in acquired demyelinating syndromes than in all other groups, and NFL was significantly higher in acquired demyelinating syndromes than in the other groups except systemic inflammatory disease. Children with acute disseminated encephalomyelitis had significantly higher concentrations of CHI3L1 than did children with multiple sclerosis.CONCLUSION: We provide class II evidence that CHI3L1 and NFL are associated with pediatric acquired demyelinating syndromes. CHI3L1 may help distinguishing between acute disseminated encephalomyelitis and multiple sclerosis, but this needs further confirmation.

KW - Adolescent

KW - Biomarkers/cerebrospinal fluid

KW - Child

KW - Child, Preschool

KW - Chitinase-3-Like Protein 1/cerebrospinal fluid

KW - Demyelinating Diseases/cerebrospinal fluid

KW - Female

KW - Humans

KW - Infant

KW - Male

KW - Neurofilament Proteins/cerebrospinal fluid

KW - Oligoclonal Bands/cerebrospinal fluid

KW - Retrospective Studies

KW - Syndrome

U2 - 10.1016/j.msard.2018.05.017

DO - 10.1016/j.msard.2018.05.017

M3 - Journal article

C2 - 30055504

VL - 24

SP - 175

EP - 183

JO - Multiple Sclerosis and Related Disorders

JF - Multiple Sclerosis and Related Disorders

SN - 2211-0348

ER -

ID: 216467140