Inflammatory markers of CHMP2B-mediated frontotemporal dementia

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Standard

Inflammatory markers of CHMP2B-mediated frontotemporal dementia. / Roos, Peter; von Essen, Marina Rode; Nielsen, Troels Tolstrup; Johannsen, Peter; Stokholm, Jette; Bie, Anne Sigaard; Waldemar, Gunhild; Simonsen, Anja Hviid; Heslegrave, Amanda; Zetterberg, Henrik; FReJA Consortium ; Sellebjerg, Finn; Nielsen, Jørgen Erik.

I: Journal of Neuroimmunology, Bind 324, 2018, s. 136-142.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Roos, P, von Essen, MR, Nielsen, TT, Johannsen, P, Stokholm, J, Bie, AS, Waldemar, G, Simonsen, AH, Heslegrave, A, Zetterberg, H, FReJA Consortium, Sellebjerg, F & Nielsen, JE 2018, 'Inflammatory markers of CHMP2B-mediated frontotemporal dementia', Journal of Neuroimmunology, bind 324, s. 136-142. https://doi.org/10.1016/j.jneuroim.2018.08.009

APA

Roos, P., von Essen, M. R., Nielsen, T. T., Johannsen, P., Stokholm, J., Bie, A. S., ... Nielsen, J. E. (2018). Inflammatory markers of CHMP2B-mediated frontotemporal dementia. Journal of Neuroimmunology, 324, 136-142. https://doi.org/10.1016/j.jneuroim.2018.08.009

Vancouver

Roos P, von Essen MR, Nielsen TT, Johannsen P, Stokholm J, Bie AS o.a. Inflammatory markers of CHMP2B-mediated frontotemporal dementia. Journal of Neuroimmunology. 2018;324:136-142. https://doi.org/10.1016/j.jneuroim.2018.08.009

Author

Roos, Peter ; von Essen, Marina Rode ; Nielsen, Troels Tolstrup ; Johannsen, Peter ; Stokholm, Jette ; Bie, Anne Sigaard ; Waldemar, Gunhild ; Simonsen, Anja Hviid ; Heslegrave, Amanda ; Zetterberg, Henrik ; FReJA Consortium ; Sellebjerg, Finn ; Nielsen, Jørgen Erik. / Inflammatory markers of CHMP2B-mediated frontotemporal dementia. I: Journal of Neuroimmunology. 2018 ; Bind 324. s. 136-142.

Bibtex

@article{13876de4ceae424ea2ed04e27860907f,
title = "Inflammatory markers of CHMP2B-mediated frontotemporal dementia",
abstract = "Histopathological studies and animal models have suggested an inflammatory component in the pathomechanism of the CHMP2B associated frontotemporal dementia (FTD-3). In this cross-sectional study, serum and cerebrospinal fluid were analyzed for inflammatory markers in CHMP2B mutation carriers. Serum levels of CCL4 were increased throughout life. Serum levels of IL-15, CXCL10, CCL22 and TNF-α were significantly associated with cognitive decline, suggesting a peripheral inflammatory response to neurodegeneration. CSF levels of sTREM2 appeared to increase more rapidly with age in CHMP2B mutation carriers. The identification of a peripheral inflammatory response to disease progression supports the involvement of an inflammatory component in FTD-3.",
author = "Peter Roos and {von Essen}, {Marina Rode} and Nielsen, {Troels Tolstrup} and Peter Johannsen and Jette Stokholm and Bie, {Anne Sigaard} and Gunhild Waldemar and Simonsen, {Anja Hviid} and Amanda Heslegrave and Henrik Zetterberg and {FReJA Consortium} and Finn Sellebjerg and Nielsen, {J{\o}rgen Erik}",
year = "2018",
doi = "10.1016/j.jneuroim.2018.08.009",
language = "English",
volume = "324",
pages = "136--142",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Inflammatory markers of CHMP2B-mediated frontotemporal dementia

AU - Roos, Peter

AU - von Essen, Marina Rode

AU - Nielsen, Troels Tolstrup

AU - Johannsen, Peter

AU - Stokholm, Jette

AU - Bie, Anne Sigaard

AU - Waldemar, Gunhild

AU - Simonsen, Anja Hviid

AU - Heslegrave, Amanda

AU - Zetterberg, Henrik

AU - FReJA Consortium

AU - Sellebjerg, Finn

AU - Nielsen, Jørgen Erik

PY - 2018

Y1 - 2018

N2 - Histopathological studies and animal models have suggested an inflammatory component in the pathomechanism of the CHMP2B associated frontotemporal dementia (FTD-3). In this cross-sectional study, serum and cerebrospinal fluid were analyzed for inflammatory markers in CHMP2B mutation carriers. Serum levels of CCL4 were increased throughout life. Serum levels of IL-15, CXCL10, CCL22 and TNF-α were significantly associated with cognitive decline, suggesting a peripheral inflammatory response to neurodegeneration. CSF levels of sTREM2 appeared to increase more rapidly with age in CHMP2B mutation carriers. The identification of a peripheral inflammatory response to disease progression supports the involvement of an inflammatory component in FTD-3.

AB - Histopathological studies and animal models have suggested an inflammatory component in the pathomechanism of the CHMP2B associated frontotemporal dementia (FTD-3). In this cross-sectional study, serum and cerebrospinal fluid were analyzed for inflammatory markers in CHMP2B mutation carriers. Serum levels of CCL4 were increased throughout life. Serum levels of IL-15, CXCL10, CCL22 and TNF-α were significantly associated with cognitive decline, suggesting a peripheral inflammatory response to neurodegeneration. CSF levels of sTREM2 appeared to increase more rapidly with age in CHMP2B mutation carriers. The identification of a peripheral inflammatory response to disease progression supports the involvement of an inflammatory component in FTD-3.

U2 - 10.1016/j.jneuroim.2018.08.009

DO - 10.1016/j.jneuroim.2018.08.009

M3 - Journal article

C2 - 30193769

VL - 324

SP - 136

EP - 142

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

ER -

ID: 216975339