Inflammatory markers of CHMP2B-mediated frontotemporal dementia

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Standard

Inflammatory markers of CHMP2B-mediated frontotemporal dementia. / Roos, Peter; von Essen, Marina Rode; Nielsen, Troels Tolstrup; Johannsen, Peter; Stokholm, Jette; Bie, Anne Sigaard; Waldemar, Gunhild; Simonsen, Anja Hviid; Heslegrave, Amanda; Zetterberg, Henrik; FReJA Consortium ; Sellebjerg, Finn; Nielsen, Jørgen Erik.

I: Journal of Neuroimmunology, Bind 324, 2018, s. 136-142.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Roos, P, von Essen, MR, Nielsen, TT, Johannsen, P, Stokholm, J, Bie, AS, Waldemar, G, Simonsen, AH, Heslegrave, A, Zetterberg, H, FReJA Consortium, Sellebjerg, F & Nielsen, JE 2018, 'Inflammatory markers of CHMP2B-mediated frontotemporal dementia', Journal of Neuroimmunology, bind 324, s. 136-142. https://doi.org/10.1016/j.jneuroim.2018.08.009

APA

Roos, P., von Essen, M. R., Nielsen, T. T., Johannsen, P., Stokholm, J., Bie, A. S., Waldemar, G., Simonsen, A. H., Heslegrave, A., Zetterberg, H., FReJA Consortium, Sellebjerg, F., & Nielsen, J. E. (2018). Inflammatory markers of CHMP2B-mediated frontotemporal dementia. Journal of Neuroimmunology, 324, 136-142. https://doi.org/10.1016/j.jneuroim.2018.08.009

Vancouver

Roos P, von Essen MR, Nielsen TT, Johannsen P, Stokholm J, Bie AS o.a. Inflammatory markers of CHMP2B-mediated frontotemporal dementia. Journal of Neuroimmunology. 2018;324:136-142. https://doi.org/10.1016/j.jneuroim.2018.08.009

Author

Roos, Peter ; von Essen, Marina Rode ; Nielsen, Troels Tolstrup ; Johannsen, Peter ; Stokholm, Jette ; Bie, Anne Sigaard ; Waldemar, Gunhild ; Simonsen, Anja Hviid ; Heslegrave, Amanda ; Zetterberg, Henrik ; FReJA Consortium ; Sellebjerg, Finn ; Nielsen, Jørgen Erik. / Inflammatory markers of CHMP2B-mediated frontotemporal dementia. I: Journal of Neuroimmunology. 2018 ; Bind 324. s. 136-142.

Bibtex

@article{13876de4ceae424ea2ed04e27860907f,
title = "Inflammatory markers of CHMP2B-mediated frontotemporal dementia",
abstract = "Histopathological studies and animal models have suggested an inflammatory component in the pathomechanism of the CHMP2B associated frontotemporal dementia (FTD-3). In this cross-sectional study, serum and cerebrospinal fluid were analyzed for inflammatory markers in CHMP2B mutation carriers. Serum levels of CCL4 were increased throughout life. Serum levels of IL-15, CXCL10, CCL22 and TNF-α were significantly associated with cognitive decline, suggesting a peripheral inflammatory response to neurodegeneration. CSF levels of sTREM2 appeared to increase more rapidly with age in CHMP2B mutation carriers. The identification of a peripheral inflammatory response to disease progression supports the involvement of an inflammatory component in FTD-3.",
author = "Peter Roos and {von Essen}, {Marina Rode} and Nielsen, {Troels Tolstrup} and Peter Johannsen and Jette Stokholm and Bie, {Anne Sigaard} and Gunhild Waldemar and Simonsen, {Anja Hviid} and Amanda Heslegrave and Henrik Zetterberg and {FReJA Consortium} and Finn Sellebjerg and Nielsen, {J{\o}rgen Erik}",
year = "2018",
doi = "10.1016/j.jneuroim.2018.08.009",
language = "English",
volume = "324",
pages = "136--142",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Inflammatory markers of CHMP2B-mediated frontotemporal dementia

AU - Roos, Peter

AU - von Essen, Marina Rode

AU - Nielsen, Troels Tolstrup

AU - Johannsen, Peter

AU - Stokholm, Jette

AU - Bie, Anne Sigaard

AU - Waldemar, Gunhild

AU - Simonsen, Anja Hviid

AU - Heslegrave, Amanda

AU - Zetterberg, Henrik

AU - FReJA Consortium

AU - Sellebjerg, Finn

AU - Nielsen, Jørgen Erik

PY - 2018

Y1 - 2018

N2 - Histopathological studies and animal models have suggested an inflammatory component in the pathomechanism of the CHMP2B associated frontotemporal dementia (FTD-3). In this cross-sectional study, serum and cerebrospinal fluid were analyzed for inflammatory markers in CHMP2B mutation carriers. Serum levels of CCL4 were increased throughout life. Serum levels of IL-15, CXCL10, CCL22 and TNF-α were significantly associated with cognitive decline, suggesting a peripheral inflammatory response to neurodegeneration. CSF levels of sTREM2 appeared to increase more rapidly with age in CHMP2B mutation carriers. The identification of a peripheral inflammatory response to disease progression supports the involvement of an inflammatory component in FTD-3.

AB - Histopathological studies and animal models have suggested an inflammatory component in the pathomechanism of the CHMP2B associated frontotemporal dementia (FTD-3). In this cross-sectional study, serum and cerebrospinal fluid were analyzed for inflammatory markers in CHMP2B mutation carriers. Serum levels of CCL4 were increased throughout life. Serum levels of IL-15, CXCL10, CCL22 and TNF-α were significantly associated with cognitive decline, suggesting a peripheral inflammatory response to neurodegeneration. CSF levels of sTREM2 appeared to increase more rapidly with age in CHMP2B mutation carriers. The identification of a peripheral inflammatory response to disease progression supports the involvement of an inflammatory component in FTD-3.

U2 - 10.1016/j.jneuroim.2018.08.009

DO - 10.1016/j.jneuroim.2018.08.009

M3 - Journal article

C2 - 30193769

VL - 324

SP - 136

EP - 142

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

ER -

ID: 216975339