The chemokine receptor CCR5 Δ32 allele in natalizumab-treated multiple sclerosis
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The chemokine receptor CCR5 Δ32 allele in natalizumab-treated multiple sclerosis. / Møller, M; Søndergaard, Helle B; Koch-Henriksen, N; Sorensen, P S; Sellebjerg, F; Oturai, A B.
I: Acta Neurologica Scandinavica, Bind 129, Nr. 1, 01.2014, s. 27-31.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - The chemokine receptor CCR5 Δ32 allele in natalizumab-treated multiple sclerosis
AU - Møller, M
AU - Søndergaard, Helle B
AU - Koch-Henriksen, N
AU - Sorensen, P S
AU - Sellebjerg, F
AU - Oturai, A B
N1 - © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
PY - 2014/1
Y1 - 2014/1
N2 - OBJECTIVE: The chemokine receptor CCR5 may be important for the recruitment of pathogenic T cells to the CNS in multiple sclerosis (MS). We hypothesized that this chemokine receptor might still be important for T-cell migration during treatment with anti-very late antigen (VLA)-4 antibody. We therefore analysed whether natalizumab-treated MS patients carrying the CCR5 Δ32 deletion allele, which results in reduced expression of CCR5 on the cell surface, had lower disease activity.METHODS: CCR5 Δ32 was analysed in 212 natalizumab-treated MS patients.RESULTS: CCR5 Δ32 status had no significant impact on the frequency of relapses 1 year prior to natalizumab treatment or during the first 48 weeks of treatment. The multiple sclerosis severity score (MSSS) was significantly lower at baseline in patients carrying CCR5 Δ32 (P = 0.031).CONCLUSIONS: CCR5 Δ32 is not associated with lower disease activity in MS patients treated with natalizumab. We found lower MSSS scores in patients carrying CCR5 Δ32 compared with the remaining patients, which is consistent with previous studies reporting an association with a more favourable disease course. Further studies are, however, needed before the relationship between CCR5 Δ32 and disease activity in MS can be definitely established.
AB - OBJECTIVE: The chemokine receptor CCR5 may be important for the recruitment of pathogenic T cells to the CNS in multiple sclerosis (MS). We hypothesized that this chemokine receptor might still be important for T-cell migration during treatment with anti-very late antigen (VLA)-4 antibody. We therefore analysed whether natalizumab-treated MS patients carrying the CCR5 Δ32 deletion allele, which results in reduced expression of CCR5 on the cell surface, had lower disease activity.METHODS: CCR5 Δ32 was analysed in 212 natalizumab-treated MS patients.RESULTS: CCR5 Δ32 status had no significant impact on the frequency of relapses 1 year prior to natalizumab treatment or during the first 48 weeks of treatment. The multiple sclerosis severity score (MSSS) was significantly lower at baseline in patients carrying CCR5 Δ32 (P = 0.031).CONCLUSIONS: CCR5 Δ32 is not associated with lower disease activity in MS patients treated with natalizumab. We found lower MSSS scores in patients carrying CCR5 Δ32 compared with the remaining patients, which is consistent with previous studies reporting an association with a more favourable disease course. Further studies are, however, needed before the relationship between CCR5 Δ32 and disease activity in MS can be definitely established.
KW - Adult
KW - Alleles
KW - Antibodies, Monoclonal, Humanized
KW - Disease Progression
KW - Female
KW - Follow-Up Studies
KW - Genotype
KW - Humans
KW - Integrin alpha4beta1
KW - Male
KW - Multiple Sclerosis, Relapsing-Remitting
KW - Prospective Studies
KW - Receptors, CCR5
KW - Sequence Deletion
KW - Severity of Illness Index
KW - Treatment Outcome
U2 - 10.1111/ane.12145
DO - 10.1111/ane.12145
M3 - Journal article
C2 - 23668375
VL - 129
SP - 27
EP - 31
JO - Acta Neurologica Scandinavica
JF - Acta Neurologica Scandinavica
SN - 0001-6314
IS - 1
ER -
ID: 138431349