Autoimmune diseases in microscopic colitis: A Danish nationwide case–control study
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Background: The association between autoimmune diseases and microscopic colitis remains uncertain. Aims: To describe the association between autoimmune diseases and microscopic colitis by using a matched case–control design based on nationwide registry data. Methods: All adult Danish patients with a diagnosis of microscopic colitis from 2001 to 2018 were identified from nationwide registries. Odds of autoimmune diseases were compared between cases with microscopic colitis and sex- and age-matched controls from the background population in a 1:10 ratio and evaluated by logistic regression calculating odds ratios (OR) with 95% confidence intervals (CI) adjusted for comorbidity. Analyses were stratified according to sex, age and the subtypes of lymphocytic and collagenous colitis. Results: We identified 15 597 cases with microscopic colitis and matched to 155 910 controls. In total, 3491 (22%) of patients with microscopic colitis had concomitant autoimmune disease compared to 16 521 (11%) of controls (OR, 2.46; 95% CI, 2.36-2.56). Adjusting for comorbidities reduced the OR to 2.09 (95% CI, 2.01-2.19). Analyses showed increased ORs with 16 different autoimmune diseases, particularly of gastrointestinal and endocrine origin, and connective tissue disorders. The highest ORs were for coeliac disease (OR = 10.15; 95% CI, 8.20-12.6), Crohn’s disease (OR = 2.47; 95% CI, 2.10-2.91) and ulcerative colitis (OR = 6.73; 95% CI, 6.20-7.30). In stratified analyses younger age at diagnosis and collagenous colitis were associated with higher odds. Conclusion: Using nationwide registry data, microscopic colitis was associated with a wide range of autoimmune diseases, especially of gastrointestinal origin. The results suggest an autoimmune predisposition to microscopic colitis.
Originalsprog | Engelsk |
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Tidsskrift | Alimentary Pharmacology and Therapeutics |
Vol/bind | 54 |
Udgave nummer | 11-12 |
Sider (fra-til) | 1454-1462 |
Antal sider | 9 |
ISSN | 0269-2813 |
DOI | |
Status | Udgivet - 2021 |
Bibliografisk note
Funding Information:
This study was funded by the Louis‐Hansen Foundation and the Aase and Ejnar Danielsens Foundation.
Funding Information:
This study was funded by the Louis-Hansen Foundation and the Aase and Ejnar Danielsens Foundation. Declaration of personal interests: None.
Publisher Copyright:
© 2021 John Wiley & Sons Ltd
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