Repeatability and reproducibility of MRI apparent diffusion coefficient applied on four different regions of interest for patients with axial spondyloarthritis and healthy volunteers scanned twice within a week

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Standard

Repeatability and reproducibility of MRI apparent diffusion coefficient applied on four different regions of interest for patients with axial spondyloarthritis and healthy volunteers scanned twice within a week. / Møller, Jakob Møllenbach; Østergaard, Mikkel; Thomsen, Henrik S; Hangaard, Stine; Sørensen, Inge J; Madsen, Ole Rintek; Pedersen, Susanne J.

I: BJR open, Bind 2, Nr. 1, 20200004, 2020.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Møller, JM, Østergaard, M, Thomsen, HS, Hangaard, S, Sørensen, IJ, Madsen, OR & Pedersen, SJ 2020, 'Repeatability and reproducibility of MRI apparent diffusion coefficient applied on four different regions of interest for patients with axial spondyloarthritis and healthy volunteers scanned twice within a week', BJR open, bind 2, nr. 1, 20200004. https://doi.org/10.1259/bjro.20200004

APA

Møller, J. M., Østergaard, M., Thomsen, H. S., Hangaard, S., Sørensen, I. J., Madsen, O. R., & Pedersen, S. J. (2020). Repeatability and reproducibility of MRI apparent diffusion coefficient applied on four different regions of interest for patients with axial spondyloarthritis and healthy volunteers scanned twice within a week. BJR open, 2(1), [20200004]. https://doi.org/10.1259/bjro.20200004

Vancouver

Møller JM, Østergaard M, Thomsen HS, Hangaard S, Sørensen IJ, Madsen OR o.a. Repeatability and reproducibility of MRI apparent diffusion coefficient applied on four different regions of interest for patients with axial spondyloarthritis and healthy volunteers scanned twice within a week. BJR open. 2020;2(1). 20200004. https://doi.org/10.1259/bjro.20200004

Author

Møller, Jakob Møllenbach ; Østergaard, Mikkel ; Thomsen, Henrik S ; Hangaard, Stine ; Sørensen, Inge J ; Madsen, Ole Rintek ; Pedersen, Susanne J. / Repeatability and reproducibility of MRI apparent diffusion coefficient applied on four different regions of interest for patients with axial spondyloarthritis and healthy volunteers scanned twice within a week. I: BJR open. 2020 ; Bind 2, Nr. 1.

Bibtex

@article{756719c07e4045719000d49360494b25,
title = "Repeatability and reproducibility of MRI apparent diffusion coefficient applied on four different regions of interest for patients with axial spondyloarthritis and healthy volunteers scanned twice within a week",
abstract = "Objectives: The apparent diffusion coefficient (ADC) may be used as a biomarker for diagnosis and/or monitoring treatment response in patients with axial spondyloarthritis (axSpA), but this requires reliable ADC measurements. This study assessed test-retest repeatability and reproducibility of ADC measurements using four different region of interest (ROI) settings.Methods: In this prospective study, the sacroiliac joints (SIJs) of 25 patients with axSpA and 24 age- and sex-matched healthy volunteers were imaged twice at a mean interval of 6.8 days in a 1.5 T scanner using, multishot echoplanar diffusion-weighted sequences. ADCs at four ROI settings were assessed: 5 mm and 10 mm anatomic band-shaped, 15 mm linear, and 40 mm2 circular.Results: Intraclass correlation coefficient (ICC) assessments showed that the interstudy repeatability was good for median ADC (ADCmed) and 95th-percentile ADC (ADC95) measurements in patients with axSpA (0.77-0.83 and 0.75-0.83, respectively), but poor-to-moderate in healthy subjects (0.27-0.55 and 0.13-0.37, respectively). For all ROI settings, intrareader reproducibility was excellent for ADCmed-measurements (ICC:0.85-0.99) and moderate-to-excellent for ADC95 measurements (ICC:0.68-0.96). The 5 mm ROI had the least estimated bias and highest level of agreement on Bland-Altman plots. The interreader reproducibility was moderate (ICC:0.71). The 15 mm linear ROI produced significantly greater ADCmed and ADC95 measurements than all other ROI settings (p < 0.01-0.02), except for the circular ROI ADC95 measurements.Conclusion: ROI settings influence ADC measurements. Interstudy repeatability of SIJ ADC measurements is independent of ROI settings. However, the 5 mm ROI showed the least bias and random error and seems preferable.Advances in knowledge: ADC measurements are affected by ROI settings, and this should be taken into account when assessing ADC maps.",
author = "M{\o}ller, {Jakob M{\o}llenbach} and Mikkel {\O}stergaard and Thomsen, {Henrik S} and Stine Hangaard and S{\o}rensen, {Inge J} and Madsen, {Ole Rintek} and Pedersen, {Susanne J}",
note = "{\textcopyright} 2020 The Authors. Published by the British Institute of Radiology.",
year = "2020",
doi = "10.1259/bjro.20200004",
language = "English",
volume = "2",
journal = "BJR open",
issn = "2513-9878",
publisher = "British Institute of Radiology",
number = "1",

}

RIS

TY - JOUR

T1 - Repeatability and reproducibility of MRI apparent diffusion coefficient applied on four different regions of interest for patients with axial spondyloarthritis and healthy volunteers scanned twice within a week

AU - Møller, Jakob Møllenbach

AU - Østergaard, Mikkel

AU - Thomsen, Henrik S

AU - Hangaard, Stine

AU - Sørensen, Inge J

AU - Madsen, Ole Rintek

AU - Pedersen, Susanne J

N1 - © 2020 The Authors. Published by the British Institute of Radiology.

PY - 2020

Y1 - 2020

N2 - Objectives: The apparent diffusion coefficient (ADC) may be used as a biomarker for diagnosis and/or monitoring treatment response in patients with axial spondyloarthritis (axSpA), but this requires reliable ADC measurements. This study assessed test-retest repeatability and reproducibility of ADC measurements using four different region of interest (ROI) settings.Methods: In this prospective study, the sacroiliac joints (SIJs) of 25 patients with axSpA and 24 age- and sex-matched healthy volunteers were imaged twice at a mean interval of 6.8 days in a 1.5 T scanner using, multishot echoplanar diffusion-weighted sequences. ADCs at four ROI settings were assessed: 5 mm and 10 mm anatomic band-shaped, 15 mm linear, and 40 mm2 circular.Results: Intraclass correlation coefficient (ICC) assessments showed that the interstudy repeatability was good for median ADC (ADCmed) and 95th-percentile ADC (ADC95) measurements in patients with axSpA (0.77-0.83 and 0.75-0.83, respectively), but poor-to-moderate in healthy subjects (0.27-0.55 and 0.13-0.37, respectively). For all ROI settings, intrareader reproducibility was excellent for ADCmed-measurements (ICC:0.85-0.99) and moderate-to-excellent for ADC95 measurements (ICC:0.68-0.96). The 5 mm ROI had the least estimated bias and highest level of agreement on Bland-Altman plots. The interreader reproducibility was moderate (ICC:0.71). The 15 mm linear ROI produced significantly greater ADCmed and ADC95 measurements than all other ROI settings (p < 0.01-0.02), except for the circular ROI ADC95 measurements.Conclusion: ROI settings influence ADC measurements. Interstudy repeatability of SIJ ADC measurements is independent of ROI settings. However, the 5 mm ROI showed the least bias and random error and seems preferable.Advances in knowledge: ADC measurements are affected by ROI settings, and this should be taken into account when assessing ADC maps.

AB - Objectives: The apparent diffusion coefficient (ADC) may be used as a biomarker for diagnosis and/or monitoring treatment response in patients with axial spondyloarthritis (axSpA), but this requires reliable ADC measurements. This study assessed test-retest repeatability and reproducibility of ADC measurements using four different region of interest (ROI) settings.Methods: In this prospective study, the sacroiliac joints (SIJs) of 25 patients with axSpA and 24 age- and sex-matched healthy volunteers were imaged twice at a mean interval of 6.8 days in a 1.5 T scanner using, multishot echoplanar diffusion-weighted sequences. ADCs at four ROI settings were assessed: 5 mm and 10 mm anatomic band-shaped, 15 mm linear, and 40 mm2 circular.Results: Intraclass correlation coefficient (ICC) assessments showed that the interstudy repeatability was good for median ADC (ADCmed) and 95th-percentile ADC (ADC95) measurements in patients with axSpA (0.77-0.83 and 0.75-0.83, respectively), but poor-to-moderate in healthy subjects (0.27-0.55 and 0.13-0.37, respectively). For all ROI settings, intrareader reproducibility was excellent for ADCmed-measurements (ICC:0.85-0.99) and moderate-to-excellent for ADC95 measurements (ICC:0.68-0.96). The 5 mm ROI had the least estimated bias and highest level of agreement on Bland-Altman plots. The interreader reproducibility was moderate (ICC:0.71). The 15 mm linear ROI produced significantly greater ADCmed and ADC95 measurements than all other ROI settings (p < 0.01-0.02), except for the circular ROI ADC95 measurements.Conclusion: ROI settings influence ADC measurements. Interstudy repeatability of SIJ ADC measurements is independent of ROI settings. However, the 5 mm ROI showed the least bias and random error and seems preferable.Advances in knowledge: ADC measurements are affected by ROI settings, and this should be taken into account when assessing ADC maps.

U2 - 10.1259/bjro.20200004

DO - 10.1259/bjro.20200004

M3 - Journal article

C2 - 33409446

VL - 2

JO - BJR open

JF - BJR open

SN - 2513-9878

IS - 1

M1 - 20200004

ER -

ID: 262751220