Neutralizing antibodies hamper IFNbeta bioactivity and treatment effect on MRI in patients with MS

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Standard

Neutralizing antibodies hamper IFNbeta bioactivity and treatment effect on MRI in patients with MS. / Sorensen, P Soelberg; Petersen, Thomas Tscherning; Kahr Mathiesen, Henrik; Langkilde, A R; Ross, C; Ravnborg, Mads; Bendtzen, K; Solberg Sorensen, P; Tscherning, MD; Langkilde, AR; Ross, C; Bendtzen, K.

I: Neurology, Bind 67, Nr. 9, 2006, s. 1681-83.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Sorensen, PS, Petersen, TT, Kahr Mathiesen, H, Langkilde, AR, Ross, C, Ravnborg, M, Bendtzen, K, Solberg Sorensen, P, Tscherning, MD, Langkilde, AR, Ross, C & Bendtzen, K 2006, 'Neutralizing antibodies hamper IFNbeta bioactivity and treatment effect on MRI in patients with MS', Neurology, bind 67, nr. 9, s. 1681-83. https://doi.org/10.1212/01.wnl.0000242884.76598.bb, https://doi.org/10.1212/01.wnl.0000242884.76598.bb

APA

Sorensen, P. S., Petersen, T. T., Kahr Mathiesen, H., Langkilde, A. R., Ross, C., Ravnborg, M., Bendtzen, K., Solberg Sorensen, P., Tscherning, MD., Langkilde, AR., Ross, C., & Bendtzen, K. (2006). Neutralizing antibodies hamper IFNbeta bioactivity and treatment effect on MRI in patients with MS. Neurology, 67(9), 1681-83. https://doi.org/10.1212/01.wnl.0000242884.76598.bb, https://doi.org/10.1212/01.wnl.0000242884.76598.bb

Vancouver

Sorensen PS, Petersen TT, Kahr Mathiesen H, Langkilde AR, Ross C, Ravnborg M o.a. Neutralizing antibodies hamper IFNbeta bioactivity and treatment effect on MRI in patients with MS. Neurology. 2006;67(9):1681-83. https://doi.org/10.1212/01.wnl.0000242884.76598.bb, https://doi.org/10.1212/01.wnl.0000242884.76598.bb

Author

Sorensen, P Soelberg ; Petersen, Thomas Tscherning ; Kahr Mathiesen, Henrik ; Langkilde, A R ; Ross, C ; Ravnborg, Mads ; Bendtzen, K ; Solberg Sorensen, P ; Tscherning, MD ; Langkilde, AR ; Ross, C ; Bendtzen, K. / Neutralizing antibodies hamper IFNbeta bioactivity and treatment effect on MRI in patients with MS. I: Neurology. 2006 ; Bind 67, Nr. 9. s. 1681-83.

Bibtex

@article{b9fe84909e8f4a168c6a9df896e44d00,
title = "Neutralizing antibodies hamper IFNbeta bioactivity and treatment effect on MRI in patients with MS",
abstract = "We measured neutralizing antibodies (NABs) and the in vivo biologic response to interferon-beta on neopterin and beta(2)-microglobulin blood levels. All NAB-negative patients had an in vivo biologic response (full or partial), whereas all high-level positive patients had no response. High-level NAB patients had more MRI activity than NAB-negative patients (p = 0.031). Patients with a full response had less MRI activity than patients without biologic response (p = 0.032).",
author = "Sorensen, {P Soelberg} and Petersen, {Thomas Tscherning} and {Kahr Mathiesen}, Henrik and Langkilde, {A R} and C Ross and Mads Ravnborg and K Bendtzen and {Solberg Sorensen}, P and MD Tscherning and AR Langkilde and C Ross and K Bendtzen",
year = "2006",
doi = "10.1212/01.wnl.0000242884.76598.bb",
language = "English",
volume = "67",
pages = "1681--83",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams & Wilkins",
number = "9",

}

RIS

TY - JOUR

T1 - Neutralizing antibodies hamper IFNbeta bioactivity and treatment effect on MRI in patients with MS

AU - Sorensen, P Soelberg

AU - Petersen, Thomas Tscherning

AU - Kahr Mathiesen, Henrik

AU - Langkilde, A R

AU - Ross, C

AU - Ravnborg, Mads

AU - Bendtzen, K

AU - Solberg Sorensen, P

AU - Tscherning, MD

AU - Langkilde, AR

AU - Ross, C

AU - Bendtzen, K

PY - 2006

Y1 - 2006

N2 - We measured neutralizing antibodies (NABs) and the in vivo biologic response to interferon-beta on neopterin and beta(2)-microglobulin blood levels. All NAB-negative patients had an in vivo biologic response (full or partial), whereas all high-level positive patients had no response. High-level NAB patients had more MRI activity than NAB-negative patients (p = 0.031). Patients with a full response had less MRI activity than patients without biologic response (p = 0.032).

AB - We measured neutralizing antibodies (NABs) and the in vivo biologic response to interferon-beta on neopterin and beta(2)-microglobulin blood levels. All NAB-negative patients had an in vivo biologic response (full or partial), whereas all high-level positive patients had no response. High-level NAB patients had more MRI activity than NAB-negative patients (p = 0.031). Patients with a full response had less MRI activity than patients without biologic response (p = 0.032).

U2 - 10.1212/01.wnl.0000242884.76598.bb

DO - 10.1212/01.wnl.0000242884.76598.bb

M3 - Journal article

C2 - 17101906

VL - 67

SP - 1681

EP - 1683

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 9

ER -

ID: 34074971