The current role of blood-based biomarkers in surgical decision-making in patients with localised pancreatic cancer: A systematic review
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Introduction: The role of blood-based biomarkers in surgical decision-making in patients with localised pancreatic cancer remains unclear. This review aimed to report the utility of blood-based biomarkers focusing on prediction of response to neoadjuvant therapy, prediction of surgical resectability and early relapse after surgery. Materials and methods: MEDLINE/PubMed, Embase and Web of Science were searched till October 2019. Studies published between January 2000 and September 2019 with a minimum of 20 patients with pancreatic adenocarcinoma, reporting the utility of at least one blood-based biomarker in predicting response to neoadjuvant therapy and predicting surgical resectability or early relapse after surgery were included. Results: A total of 2604 studies were identified, of which 24 comprising of 3367 patients and 12 blood-based biomarkers were included. All included studies were observational. Levels of carbohydrate antigen (CA)19-9 were reported in the majority of the studies. Levels of CA19-9 predicted the response to neoadjuvant therapy and early relapse in 10 studies. CA125 levels above 35 U/ml were predictive of surgical irresectability in two studies. However, marked variation in both timing of sampling and cut-off values was noted between studies. Conclusion: Despite some evidence of potential benefit, the utility of currently available blood-based biomarkers in aiding surgical decision-making in patients undergoing potentially curative treatment for pancreatic cancer is limited by methodological heterogeneity. Standardisation of future studies may allow a more comprehensive analysis of the biomarkers described in this review.
Originalsprog | Engelsk |
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Tidsskrift | European Journal of Cancer |
Vol/bind | 154 |
Sider (fra-til) | 73-81 |
Antal sider | 9 |
ISSN | 0959-8049 |
DOI | |
Status | Udgivet - 2021 |
Bibliografisk note
Funding Information:
Funding sources: This work was supported by the Danish Cancer Society (grant number R218-A13160 , 2019), covering the salary to Hadi M.H. Diab.
Publisher Copyright:
© 2021 Elsevier Ltd
ID: 303030484