Common genetic variants and modification of penetrance of BRCA2-associated breast cancer

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

  • Mia M Gaudet
  • Tomas Kirchhoff
  • Todd Green
  • Joseph Vijai
  • Joshua M Korn
  • Candace Guiducci
  • Ayellet V Segrè
  • Kate McGee
  • Lesley McGuffog
  • Christiana Kartsonaki
  • Jonathan Morrison
  • Sue Healey
  • Olga M Sinilnikova
  • Dominique Stoppa-Lyonnet
  • Sylvie Mazoyer
  • Marion Gauthier-Villars
  • Hagay Sobol
  • Michel Longy
  • Marc Frenay
  • GEMO Study Collaborators
  • Frans B L Hogervorst
  • Matti A Rookus
  • J Margriet Collée
  • Nicoline Hoogerbrugge
  • Kees E P van Roozendaal
  • Marion Piedmonte
  • Wendy Rubinstein
  • Stacy Nerenstone
  • Linda Van Le
  • Stephanie V Blank
  • Trinidad Caldés
  • Miguel de la Hoya
  • Heli Nevanlinna
  • Kristiina Aittomäki
  • Conxi Lazaro
  • Ignacio Blanco
  • Adalgeir Arason
  • Oskar T Johannsson
  • Rosa B Barkardottir
  • Peter Devilee
  • Olofunmilayo I Olopade
  • Susan L Neuhausen
  • Xianshu Wang
  • Zachary S Fredericksen
  • Paolo Peterlongo
  • Siranoush Manoukian
  • Monica Barile
  • Alessandra Viel
  • Hansen, Thomas van Overeem
  • Nielsen, Finn Cilius
  • HEBON Study Collaborators
The considerable uncertainty regarding cancer risks associated with inherited mutations of BRCA2 is due to unknown factors. To investigate whether common genetic variants modify penetrance for BRCA2 mutation carriers, we undertook a two-staged genome-wide association study in BRCA2 mutation carriers. In stage 1 using the Affymetrix 6.0 platform, 592,163 filtered SNPs genotyped were available on 899 young (
OriginalsprogEngelsk
TidsskriftP L o S Genetics
Vol/bind6
Udgave nummer10
Sider (fra-til)e1001183
ISSN1553-7390
DOI
StatusUdgivet - 1 okt. 2010

ID: 34120277