The effect of ferritin-guided iron supplementation among Danish female first-time blood donors
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Background
The identification of blood donors at risk of developing low hemoglobin (Hb) and subsequent intervention is expected to reduce donation-induced iron deficiency and low Hb among blood donors. This study explores the effects of ferritin-guided iron supplementation for female first-time donors implemented in four of five administrative regions in Denmark.
Study Design and Methods
We included 45,919 female first-time donors in this study. Hb values were determined in donations of included donors during a 2-year follow-up period. For each region, an intervention group (after implementation) and a control group (before implementation) were defined. The primary outcome was Hb below the donation threshold (7.8 mmol/L ~ 12.5 g/dL) at the time of donation, in the control group, and the intervention group, using logistic regression. The secondary outcome was the number of donations per donor given during the follow-up period.
Results
We observed a statistically significant decrease in the risk of female first-time donors experiencing a donation with low Hb after ferritin-guided iron supplementation was introduced: Odds ratio, 0.82; 95% confidence interval (CI), 0.71–0.95. We found a statistically significant increase in the number of donations per donor during the follow-up period after intervention; rate ratio: 1.05, 95% CI: 1.02–1.08.
Discussion
Ferritin-guided iron supplementation led to a significant reduction in the occurrence of low hemoglobin (Hb) levels among Danish female first-time blood donors. The intervention was additionally associated with an increase in the number of donations per donor.
Originalsprog | Engelsk |
---|---|
Tidsskrift | Transfusion |
Vol/bind | 63 |
Udgave nummer | 9 |
Sider (fra-til) | 1710-1718 |
Antal sider | 9 |
ISSN | 0041-1132 |
DOI | |
Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:
The study was supported by Abbott Diagnostics. The study infrastructure was supported by grants from BERTHA—the Danish Big Data Centre for Environment and Health funded by the Novo Nordisk Foundation Challenge Programme (grant NNF17OC0027864), Danish Administrative Regions, and Bio‐ and Genome Bank Denmark.
Publisher Copyright:
© 2023 The Authors. Transfusion published by Wiley Periodicals LLC on behalf of AABB.
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