The neuroanatomical and neurochemical basis of apathy and impulsivity in frontotemporal lobar degeneration

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

The neuroanatomical and neurochemical basis of apathy and impulsivity in frontotemporal lobar degeneration. / Passamonti, L.; Lansdall, C. J.; Rowe, J. B.

I: Current Opinion in Behavioral Sciences, Bind 22, 2018, s. 14-20.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Passamonti, L, Lansdall, CJ & Rowe, JB 2018, 'The neuroanatomical and neurochemical basis of apathy and impulsivity in frontotemporal lobar degeneration', Current Opinion in Behavioral Sciences, bind 22, s. 14-20. https://doi.org/10.1016/j.cobeha.2017.12.015

APA

Passamonti, L., Lansdall, C. J., & Rowe, J. B. (2018). The neuroanatomical and neurochemical basis of apathy and impulsivity in frontotemporal lobar degeneration. Current Opinion in Behavioral Sciences, 22, 14-20. https://doi.org/10.1016/j.cobeha.2017.12.015

Vancouver

Passamonti L, Lansdall CJ, Rowe JB. The neuroanatomical and neurochemical basis of apathy and impulsivity in frontotemporal lobar degeneration. Current Opinion in Behavioral Sciences. 2018;22:14-20. https://doi.org/10.1016/j.cobeha.2017.12.015

Author

Passamonti, L. ; Lansdall, C. J. ; Rowe, J. B. / The neuroanatomical and neurochemical basis of apathy and impulsivity in frontotemporal lobar degeneration. I: Current Opinion in Behavioral Sciences. 2018 ; Bind 22. s. 14-20.

Bibtex

@article{d19f6eb1e6e1454ea66fcbc5e32f7dec,
title = "The neuroanatomical and neurochemical basis of apathy and impulsivity in frontotemporal lobar degeneration",
abstract = "Apathy and impulsivity are common and often coexistent consequences of frontotemporal lobar degeneration (FTLD). They increase patient morbidity and carer distress, but remain under-estimated and poorly treated. Recent trans-diagnostic approaches that span the spectrum of clinical presentations of FTLD and parkinsonism, indicate that apathy and impulsivity can be fractionated into multiple neuroanatomical and pharmacological systems. These include ventral/dorsal frontostriatal circuits for reward-sensitivity, response-inhibition, and decision-making; moderated by noradrenaline, dopamine, and serotonin. Improved assessment tools, formal models of cognition and behavior, combined with brain imaging and psychopharmacology, are creating new therapeutic targets and establishing principles for stratification in future clinical trials.",
author = "L. Passamonti and Lansdall, {C. J.} and Rowe, {J. B.}",
year = "2018",
doi = "10.1016/j.cobeha.2017.12.015",
language = "English",
volume = "22",
pages = "14--20",
journal = "Current Opinion in Behavioral Sciences",
issn = "2352-1546",
publisher = "Elsevier Limited",

}

RIS

TY - JOUR

T1 - The neuroanatomical and neurochemical basis of apathy and impulsivity in frontotemporal lobar degeneration

AU - Passamonti, L.

AU - Lansdall, C. J.

AU - Rowe, J. B.

PY - 2018

Y1 - 2018

N2 - Apathy and impulsivity are common and often coexistent consequences of frontotemporal lobar degeneration (FTLD). They increase patient morbidity and carer distress, but remain under-estimated and poorly treated. Recent trans-diagnostic approaches that span the spectrum of clinical presentations of FTLD and parkinsonism, indicate that apathy and impulsivity can be fractionated into multiple neuroanatomical and pharmacological systems. These include ventral/dorsal frontostriatal circuits for reward-sensitivity, response-inhibition, and decision-making; moderated by noradrenaline, dopamine, and serotonin. Improved assessment tools, formal models of cognition and behavior, combined with brain imaging and psychopharmacology, are creating new therapeutic targets and establishing principles for stratification in future clinical trials.

AB - Apathy and impulsivity are common and often coexistent consequences of frontotemporal lobar degeneration (FTLD). They increase patient morbidity and carer distress, but remain under-estimated and poorly treated. Recent trans-diagnostic approaches that span the spectrum of clinical presentations of FTLD and parkinsonism, indicate that apathy and impulsivity can be fractionated into multiple neuroanatomical and pharmacological systems. These include ventral/dorsal frontostriatal circuits for reward-sensitivity, response-inhibition, and decision-making; moderated by noradrenaline, dopamine, and serotonin. Improved assessment tools, formal models of cognition and behavior, combined with brain imaging and psychopharmacology, are creating new therapeutic targets and establishing principles for stratification in future clinical trials.

UR - http://www.scopus.com/inward/record.url?scp=85039937171&partnerID=8YFLogxK

U2 - 10.1016/j.cobeha.2017.12.015

DO - 10.1016/j.cobeha.2017.12.015

M3 - Review

C2 - 31032387

AN - SCOPUS:85039937171

VL - 22

SP - 14

EP - 20

JO - Current Opinion in Behavioral Sciences

JF - Current Opinion in Behavioral Sciences

SN - 2352-1546

ER -

ID: 220844980