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A meta-analysis uncovers the first sequence variant conferring risk of Bell’s palsy. / Skuladottir, Astros Th; Bjornsdottir, Gyda; Thorleifsson, Gudmar; Walters, G. Bragi; Nawaz, Muhammad Sulaman; Moore, Kristjan Helgi Swerford; Olason, Pall I.; Thorgeirsson, Thorgeir E.; Sigurpalsdottir, Brynja; Sveinbjornsson, Gardar; Eggertsson, Hannes P.; Magnusson, Sigurdur H.; Oddsson, Asmundur; Bjornsdottir, Anna; Vikingsson, Arnor; Sveinsson, Olafur A.; Hrafnsdottir, Maria G.; Sigurdardottir, Gudrun R.; Halldorsson, Bjarni V.; Hansen, Thomas Folkmann; Paarup, Helene; Erikstrup, Christian; Nielsen, Kaspar; Klokker, Mads; Bruun, Mie Topholm; Sørensen, Erik; Banasik, Karina; Burgdorf, Kristoffer S.; Pedersen, Ole Birger; Ullum, Henrik; Jonsdottir, Ingileif; Stefansson, Hreinn; Stefansson, Kari.
I:
Scientific Reports, Bind 11, Nr. 1, 4188, 2021.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
Skuladottir, AT, Bjornsdottir, G, Thorleifsson, G, Walters, GB, Nawaz, MS, Moore, KHS, Olason, PI, Thorgeirsson, TE, Sigurpalsdottir, B, Sveinbjornsson, G, Eggertsson, HP, Magnusson, SH, Oddsson, A, Bjornsdottir, A, Vikingsson, A, Sveinsson, OA, Hrafnsdottir, MG, Sigurdardottir, GR, Halldorsson, BV
, Hansen, TF, Paarup, H, Erikstrup, C, Nielsen, K
, Klokker, M, Bruun, MT, Sørensen, E
, Banasik, K, Burgdorf, KS, Pedersen, OB, Ullum, H, Jonsdottir, I, Stefansson, H & Stefansson, K 2021, '
A meta-analysis uncovers the first sequence variant conferring risk of Bell’s palsy',
Scientific Reports, bind 11, nr. 1, 4188.
https://doi.org/10.1038/s41598-021-82736-wAPA
Skuladottir, A. T., Bjornsdottir, G., Thorleifsson, G., Walters, G. B., Nawaz, M. S., Moore, K. H. S., Olason, P. I., Thorgeirsson, T. E., Sigurpalsdottir, B., Sveinbjornsson, G., Eggertsson, H. P., Magnusson, S. H., Oddsson, A., Bjornsdottir, A., Vikingsson, A., Sveinsson, O. A., Hrafnsdottir, M. G., Sigurdardottir, G. R., Halldorsson, B. V., ... Stefansson, K. (2021).
A meta-analysis uncovers the first sequence variant conferring risk of Bell’s palsy.
Scientific Reports,
11(1), [4188].
https://doi.org/10.1038/s41598-021-82736-wVancouver
Skuladottir AT, Bjornsdottir G, Thorleifsson G, Walters GB, Nawaz MS, Moore KHS o.a.
A meta-analysis uncovers the first sequence variant conferring risk of Bell’s palsy.
Scientific Reports. 2021;11(1). 4188.
https://doi.org/10.1038/s41598-021-82736-wAuthor
Skuladottir, Astros Th ; Bjornsdottir, Gyda ; Thorleifsson, Gudmar ; Walters, G. Bragi ; Nawaz, Muhammad Sulaman ; Moore, Kristjan Helgi Swerford ; Olason, Pall I. ; Thorgeirsson, Thorgeir E. ; Sigurpalsdottir, Brynja ; Sveinbjornsson, Gardar ; Eggertsson, Hannes P. ; Magnusson, Sigurdur H. ; Oddsson, Asmundur ; Bjornsdottir, Anna ; Vikingsson, Arnor ; Sveinsson, Olafur A. ; Hrafnsdottir, Maria G. ; Sigurdardottir, Gudrun R. ; Halldorsson, Bjarni V. ; Hansen, Thomas Folkmann ; Paarup, Helene ; Erikstrup, Christian ; Nielsen, Kaspar ; Klokker, Mads ; Bruun, Mie Topholm ; Sørensen, Erik ; Banasik, Karina ; Burgdorf, Kristoffer S. ; Pedersen, Ole Birger ; Ullum, Henrik ; Jonsdottir, Ingileif ; Stefansson, Hreinn ; Stefansson, Kari. / A meta-analysis uncovers the first sequence variant conferring risk of Bell’s palsy. I: Scientific Reports. 2021 ; Bind 11, Nr. 1.
Bibtex
@article{27117702be39497cb75367d36669db74,
title = "A meta-analysis uncovers the first sequence variant conferring risk of Bell{\textquoteright}s palsy",
abstract = "Bell{\textquoteright}s palsy is the most common cause of unilateral facial paralysis and is defined as an idiopathic and acute inability to control movements of the facial muscles on the affected side. While the pathogenesis remains unknown, previous studies have implicated post-viral inflammation and resulting compression of the facial nerve. Reported heritability estimates of 4–14% suggest a genetic component in the etiology and an autosomal dominant inheritance has been proposed. Here, we report findings from a meta-analysis of genome-wide association studies uncovering the first unequivocal association with Bell{\textquoteright}s palsy (rs9357446-A; P = 6.79 × 10−23, OR = 1.23; Ncases = 4714, Ncontrols = 1,011,520). The variant also confers risk of intervertebral disc disorders (P = 2.99 × 10−11, OR = 1.04) suggesting a common pathogenesis in part or a true pleiotropy.",
author = "Skuladottir, {Astros Th} and Gyda Bjornsdottir and Gudmar Thorleifsson and Walters, {G. Bragi} and Nawaz, {Muhammad Sulaman} and Moore, {Kristjan Helgi Swerford} and Olason, {Pall I.} and Thorgeirsson, {Thorgeir E.} and Brynja Sigurpalsdottir and Gardar Sveinbjornsson and Eggertsson, {Hannes P.} and Magnusson, {Sigurdur H.} and Asmundur Oddsson and Anna Bjornsdottir and Arnor Vikingsson and Sveinsson, {Olafur A.} and Hrafnsdottir, {Maria G.} and Sigurdardottir, {Gudrun R.} and Halldorsson, {Bjarni V.} and Hansen, {Thomas Folkmann} and Helene Paarup and Christian Erikstrup and Kaspar Nielsen and Mads Klokker and Bruun, {Mie Topholm} and Erik S{\o}rensen and Karina Banasik and Burgdorf, {Kristoffer S.} and Pedersen, {Ole Birger} and Henrik Ullum and Ingileif Jonsdottir and Hreinn Stefansson and Kari Stefansson",
year = "2021",
doi = "10.1038/s41598-021-82736-w",
language = "English",
volume = "11",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "nature publishing group",
number = "1",
}
RIS
TY - JOUR
T1 - A meta-analysis uncovers the first sequence variant conferring risk of Bell’s palsy
AU - Skuladottir, Astros Th
AU - Bjornsdottir, Gyda
AU - Thorleifsson, Gudmar
AU - Walters, G. Bragi
AU - Nawaz, Muhammad Sulaman
AU - Moore, Kristjan Helgi Swerford
AU - Olason, Pall I.
AU - Thorgeirsson, Thorgeir E.
AU - Sigurpalsdottir, Brynja
AU - Sveinbjornsson, Gardar
AU - Eggertsson, Hannes P.
AU - Magnusson, Sigurdur H.
AU - Oddsson, Asmundur
AU - Bjornsdottir, Anna
AU - Vikingsson, Arnor
AU - Sveinsson, Olafur A.
AU - Hrafnsdottir, Maria G.
AU - Sigurdardottir, Gudrun R.
AU - Halldorsson, Bjarni V.
AU - Hansen, Thomas Folkmann
AU - Paarup, Helene
AU - Erikstrup, Christian
AU - Nielsen, Kaspar
AU - Klokker, Mads
AU - Bruun, Mie Topholm
AU - Sørensen, Erik
AU - Banasik, Karina
AU - Burgdorf, Kristoffer S.
AU - Pedersen, Ole Birger
AU - Ullum, Henrik
AU - Jonsdottir, Ingileif
AU - Stefansson, Hreinn
AU - Stefansson, Kari
PY - 2021
Y1 - 2021
N2 - Bell’s palsy is the most common cause of unilateral facial paralysis and is defined as an idiopathic and acute inability to control movements of the facial muscles on the affected side. While the pathogenesis remains unknown, previous studies have implicated post-viral inflammation and resulting compression of the facial nerve. Reported heritability estimates of 4–14% suggest a genetic component in the etiology and an autosomal dominant inheritance has been proposed. Here, we report findings from a meta-analysis of genome-wide association studies uncovering the first unequivocal association with Bell’s palsy (rs9357446-A; P = 6.79 × 10−23, OR = 1.23; Ncases = 4714, Ncontrols = 1,011,520). The variant also confers risk of intervertebral disc disorders (P = 2.99 × 10−11, OR = 1.04) suggesting a common pathogenesis in part or a true pleiotropy.
AB - Bell’s palsy is the most common cause of unilateral facial paralysis and is defined as an idiopathic and acute inability to control movements of the facial muscles on the affected side. While the pathogenesis remains unknown, previous studies have implicated post-viral inflammation and resulting compression of the facial nerve. Reported heritability estimates of 4–14% suggest a genetic component in the etiology and an autosomal dominant inheritance has been proposed. Here, we report findings from a meta-analysis of genome-wide association studies uncovering the first unequivocal association with Bell’s palsy (rs9357446-A; P = 6.79 × 10−23, OR = 1.23; Ncases = 4714, Ncontrols = 1,011,520). The variant also confers risk of intervertebral disc disorders (P = 2.99 × 10−11, OR = 1.04) suggesting a common pathogenesis in part or a true pleiotropy.
U2 - 10.1038/s41598-021-82736-w
DO - 10.1038/s41598-021-82736-w
M3 - Journal article
C2 - 33602968
AN - SCOPUS:85101028953
VL - 11
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
IS - 1
M1 - 4188
ER -
