Mesenchymal stem cell therapy for laryngotracheal stenosis: A systematic review of preclinical studies
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Mesenchymal stem cell therapy for laryngotracheal stenosis : A systematic review of preclinical studies. / Jakobsen, Kathrine Kronberg; Grønhøj, Christian; Jensen, David H; Fischer-Nielsen, Anne; Hjuler, Thomas; von Buchwald, Christian.
I: PLOS ONE, Bind 12, Nr. 9, e0185283, 2017.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Mesenchymal stem cell therapy for laryngotracheal stenosis
T2 - A systematic review of preclinical studies
AU - Jakobsen, Kathrine Kronberg
AU - Grønhøj, Christian
AU - Jensen, David H
AU - Fischer-Nielsen, Anne
AU - Hjuler, Thomas
AU - von Buchwald, Christian
PY - 2017
Y1 - 2017
N2 - BACKGROUND: Laryngotracheal stenosis (LTS) can be either congenital or acquired. Laryngeal stenosis is most often encountered after prolonged intubation. The mechanism for stenosis following intubation is believed to be hypertrophic scarring. Mesenchymal stem cells (MSCs) therapy has shown promising results in regenerative medicine. We aimed to systematically review the literature on MSC therapy for stenosis of the conductive airways.METHODS: PubMed, EMBASE, Google Scholar and the Cochrane Library were systematically searched from January 1980-January 2017 with the purpose of identifying all studies addressing the effect of MSC therapy on the airway. We assessed effect on inflammation, fibrosis, and MSC as a component in tissue engineering for treating defects in the airway.RESULTS: We identified eleven studies (n = 256 animals) from eight countries evaluating the effect of MSCs as a regenerative therapy in the upper airways. The studies indicate that MSC therapy may lead to a more constructive inflammatory response as well as support tissue regeneration.CONCLUSION: There may be a favorable effect of MSCs in inhibiting inflammation and as a component in tissue engineering. Given the heterogeneous nature of the included animal studies, any clear conclusion regarding the effect of tracheal stenosis in human subjects cannot be drawn. The included preclinical studies are however encouraging for further research.
AB - BACKGROUND: Laryngotracheal stenosis (LTS) can be either congenital or acquired. Laryngeal stenosis is most often encountered after prolonged intubation. The mechanism for stenosis following intubation is believed to be hypertrophic scarring. Mesenchymal stem cells (MSCs) therapy has shown promising results in regenerative medicine. We aimed to systematically review the literature on MSC therapy for stenosis of the conductive airways.METHODS: PubMed, EMBASE, Google Scholar and the Cochrane Library were systematically searched from January 1980-January 2017 with the purpose of identifying all studies addressing the effect of MSC therapy on the airway. We assessed effect on inflammation, fibrosis, and MSC as a component in tissue engineering for treating defects in the airway.RESULTS: We identified eleven studies (n = 256 animals) from eight countries evaluating the effect of MSCs as a regenerative therapy in the upper airways. The studies indicate that MSC therapy may lead to a more constructive inflammatory response as well as support tissue regeneration.CONCLUSION: There may be a favorable effect of MSCs in inhibiting inflammation and as a component in tissue engineering. Given the heterogeneous nature of the included animal studies, any clear conclusion regarding the effect of tracheal stenosis in human subjects cannot be drawn. The included preclinical studies are however encouraging for further research.
KW - Animals
KW - Fibrosis
KW - Humans
KW - Larynx/pathology
KW - Mesenchymal Stem Cell Transplantation/methods
KW - Tracheal Stenosis/complications
KW - Treatment Outcome
U2 - 10.1371/journal.pone.0185283
DO - 10.1371/journal.pone.0185283
M3 - Review
C2 - 28934345
VL - 12
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 9
M1 - e0185283
ER -
ID: 195961412