Exploring the interplay between psychotic experiences, functional somatic symptoms and health anxiety in childhood and adolescence – A longitudinal cohort study
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Exploring the interplay between psychotic experiences, functional somatic symptoms and health anxiety in childhood and adolescence – A longitudinal cohort study. / Rimvall, Martin Køster; Rask, Charlotte Ulrikka; Jensen, Jens Søndergaard; Olsen, Else Marie; Clemmensen, Lars; Skovgaard, Anne Mette; Verhulst, Frank; van Os, Jim; Jeppesen, Pia.
In: Schizophrenia Research, Vol. 267, 2024, p. 322-329.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Exploring the interplay between psychotic experiences, functional somatic symptoms and health anxiety in childhood and adolescence – A longitudinal cohort study
AU - Rimvall, Martin Køster
AU - Rask, Charlotte Ulrikka
AU - Jensen, Jens Søndergaard
AU - Olsen, Else Marie
AU - Clemmensen, Lars
AU - Skovgaard, Anne Mette
AU - Verhulst, Frank
AU - van Os, Jim
AU - Jeppesen, Pia
N1 - Publisher Copyright: © 2024 Elsevier B.V.
PY - 2024
Y1 - 2024
N2 - Background: Similarities exist between contemporary explanatory models underlying psychosis development, functional somatic symptoms, and health anxiety. The current study aimed to examine the potential interplay between psychotic experiences (and alternate measures of anomalous self-experiences and aberrant attribution of salience) and functional somatic symptoms on the outcome of health anxiety in youths. Methods: In a prospective general-population birth cohort, the Copenhagen Child Cohort 2000 (CCC2000), data from two time-points were available for 1122 individuals. We assessed the associations between psychotic experiences and functional somatic symptoms with health anxiety both cross-sectionally at ages 11- and 16-years, and longitudinally from age 11 to 16. Further, we examined if there was an interaction between these two domains on the outcome of health anxiety using the interaction contrast ratio. Results: Functional somatic symptoms and psychotic experiences were strongly cross-sectionally associated with health anxiety at both ages 11 and 16, even after adjustment for general psychopathology. In the longitudinal analyses, functional somatic symptoms, and psychotic experiences at age 11 were not individually associated with health anxiety at age 16 but having both functional somatic symptoms and psychotic experiences was: odds ratio 3.90, 95%CI 1.7–8.9, with suggestion of evidence for interaction beyond the additive effects. This association was attenuated after adjustment for general psychopathology: odds ratio 2.6, 95 % CI 1.0–6.4. Conclusion: The strong associations between the domains support the idea of possible overlapping mechanisms underlying psychotic experiences, functional somatic symptoms, and health anxiety.
AB - Background: Similarities exist between contemporary explanatory models underlying psychosis development, functional somatic symptoms, and health anxiety. The current study aimed to examine the potential interplay between psychotic experiences (and alternate measures of anomalous self-experiences and aberrant attribution of salience) and functional somatic symptoms on the outcome of health anxiety in youths. Methods: In a prospective general-population birth cohort, the Copenhagen Child Cohort 2000 (CCC2000), data from two time-points were available for 1122 individuals. We assessed the associations between psychotic experiences and functional somatic symptoms with health anxiety both cross-sectionally at ages 11- and 16-years, and longitudinally from age 11 to 16. Further, we examined if there was an interaction between these two domains on the outcome of health anxiety using the interaction contrast ratio. Results: Functional somatic symptoms and psychotic experiences were strongly cross-sectionally associated with health anxiety at both ages 11 and 16, even after adjustment for general psychopathology. In the longitudinal analyses, functional somatic symptoms, and psychotic experiences at age 11 were not individually associated with health anxiety at age 16 but having both functional somatic symptoms and psychotic experiences was: odds ratio 3.90, 95%CI 1.7–8.9, with suggestion of evidence for interaction beyond the additive effects. This association was attenuated after adjustment for general psychopathology: odds ratio 2.6, 95 % CI 1.0–6.4. Conclusion: The strong associations between the domains support the idea of possible overlapping mechanisms underlying psychotic experiences, functional somatic symptoms, and health anxiety.
KW - Aberrant attribution of salience
KW - Anomalous self-experiences
KW - Functional somatic symptoms
KW - Health anxiety
KW - Subclinical psychosis
U2 - 10.1016/j.schres.2024.03.028
DO - 10.1016/j.schres.2024.03.028
M3 - Journal article
C2 - 38613863
AN - SCOPUS:85190101433
VL - 267
SP - 322
EP - 329
JO - Schizophrenia Research
JF - Schizophrenia Research
SN - 0920-9964
ER -
ID: 389506637