Ruth Frikke-Schmidt

Ruth Frikke-Schmidt

Clinical Professor

Member of:

  • Clinical Biochemistry


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  1. Published

    Body mass index and risk of Alzheimer's disease: A mendelian randomization study of 399,536 individuals

    Nordestgaard, L. T., Tybjærg-Hansen, Anne, Nordestgaard, Børge & Frikke-Schmidt, Ruth, Jul 2017, In: Journal of Clinical Endocrinology and Metabolism. 102, 7, p. 2310-2320 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Blood–brain barrier transcytosis genes, risk of dementia and stroke: a prospective cohort study of 74,754 individuals

    Juul Rasmussen, I., Tybjærg-Hansen, Anne, Rasmussen, K. L., Nordestgaard, Børge & Frikke-Schmidt, Ruth, 2019, In: European Journal of Epidemiology. 34, 6, p. 579-590 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Blood-Pressure Targets in Comatose Survivors of Cardiac Arrest

    Kjaergaard, J., Møller, J. E., Schmidt, H., Grand, J., Mølstrøm, S., Borregaard, B., Venø, S., Sarkisian, L., Mamaev, D., Jensen, L. O., Nyholm, B., Høfsten, D. E., Josiassen, J., Thomsen, J. H., Thune, J. J., Obling, L. E. R., Lindholm, M. G., Frydland, M., Meyer, M. A. S., Winther-Jensen, M. & 7 others, Beske, R. P., Frikke-Schmidt, Ruth, Wiberg, S., Boesgaard, S., Madsen, S. A., Jørgensen, Vibeke Renée Lind & Hassager, Christian, 2022, In: New England Journal of Medicine. 387, 16, p. 1456-1466 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Blood Leukocyte Counts in Alzheimer Disease

    Luo, J., Thomassen, J. Q., Nordestgaard, Børge, Tybjærg-Hansen, Anne & Frikke-Schmidt, Ruth, 2022, In: JAMA network open. 5, 10, 14 p., E2235648.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Biomarkers predictive of late cardiogenic shock development in patients with suspected ST-elevation myocardial infarction

    Frydland, M., Moller, J. E., Lindholm, M. G., Hansen, R., Wiberg, S., Helgestad, O. K. L., Thomsen, J. H., Goetze, Jens P. , Engstrøm, Thomas, Frikke-Schmidt, Ruth, Ravn, H. B., Holmvang, Lene, Jensen, L. O., Kjaergaard, J. & Hassager, Christian, 2020, In: European Heart Journal: Acute Cardiovascular Care. 9, 6, p. 557–566

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Biomarkers of Clot Activation and Degradation and Risk of Future Major Cardiovascular Events in Acute Exacerbation of COPD: A Cohort Sub-Study in a Randomized Trial Population

    Kamstrup, P., Sand, J. M. B., Ulrik, C. S., Janner, J., Ronn, C. P., Ronnow, S. R., Leeming, D. J., Jensen, S. G., Wilcke, T., Mathioudakis, A. G., Miravitlles, M., Lapperre, T., Bendstrup, E., Frikke-Schmidt, R., Murray, D. D., Itenov, T., Bossios, A., Nielsen, S. D., Vestbo, J., Biering-Sorensen, T. & 3 others, Karsdal, M., Jensen , Jens-Ulrik Stæhr & Sivapalan, P., 2022, In: Biomedicines. 10, 8, 12 p., 2011.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Associations of Alzheimer Disease-Protective APOE Variants With Age-Related Macular Degeneration

    Rasmussen, Katrine Laura, Tybjærg-Hansen, Anne, Nordestgaard, Børge & Frikke-Schmidt, Ruth, 2023, In: JAMA Ophthalmology. 141, 1, p. 13-21 9 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  8. Published

    Associations between primary care electrocardiography and non-Alzheimer dementia

    Isaksen, Jonas L., Ghouse, Jonas, Skov, M. W., Olesen, Morten Steen Salling, Holst, A. G., Pietersen, A., Nielsen, J. B., Maier, A. M., Graff, C., Frikke-Schmidt, Ruth & Kanters, Jørgen K., 10 Jul 2022, In: Journal of Stroke & Cerebrovascular Diseases. 31, 9, 7 p., 106640.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Association of loss-of-function mutations in the ABCA1 gene with high-density lipoprotein cholesterol levels and risk of ischemic heart disease

    Frikke-Schmidt, Ruth, Nordestgaard, B. G., Stene, M. C. A., Sethi, A. A., Remaley, A. T., Schnohr, P., Grande, P. & Tybjaerg-Hansen, A., 2008, In: JAMA - Journal of the American Medical Association. 299, 21, p. 2524-2532 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Association of anthropometry and weight change with risk of dementia and its major subtypes: A meta-analysis consisting 2.8 million adults with 57 294 cases of dementia

    Lee, C. M. Y., Woodward, M., Batty, G. D., Beiser, A. S., Bell, S., Berr, C., Bjertness, E., Chalmers, J., Clarke, R., Dartigues, J. F., Davis-Plourde, K., Debette, S., Di Angelantonio, E., Feart, C., Frikke-Schmidt, R., Gregson, J., Haan, M. N., Hassing, L. B., Hayden, K. M., Hoevenaar-Blom, M. P. & 26 others, Kaprio, J., Kivimaki, M., Lappas, G., Larson, E. B., LeBlanc, E. S., Lee, A., Lui, L. Y., Moll van Charante, E. P., Ninomiya, T., Nordestgaard, L. T., Ohara, T., Ohkuma, T., Palviainen, T., Peres, K., Peters, R., Qizilbash, N., Richard, E., Rosengren, A., Seshadri, S., Shipley, M., Singh-Manoux, A., Strand, B. H., van Gool, W. A., Vuoksimaa, E., Yaffe, K. & Huxley, R. R., Apr 2020, In: Obesity Reviews. 21, 4, 14 p., e12989.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Association of Rare APOE Missense Variants V236E and R251G with Risk of Alzheimer Disease

    Le Guen, Y., Belloy, M. E., Grenier-Boley, B., De Rojas, I., Castillo-Morales, A., Jansen, I., Nicolas, A., Bellenguez, C., Dalmasso, C., Küçükali, F., Eger, S. J., Rasmussen, K. L., Thomassen, J. Q., Deleuze, J. F., He, Z., Napolioni, V., Amouyel, P., Jessen, F., Kehoe, P. G., Van Duijn, C. & 89 others, Tsolaki, M., Sánchez-Juan, P., Sleegers, K., Ingelsson, M., Rossi, G., Hiltunen, M., Sims, R., Van Der Flier, W. M., Ramirez, A., Andreassen, O. A., Frikke-Schmidt, Ruth, Williams, J., Ruiz, A., Lambert, J. C., Greicius, M. D., Arosio, B., Benussi, L., Boland, A., Borroni, B., Caffarra, P., Daian, D., Daniele, A., Debette, S., Dufouil, C., Düzel, E., Galimberti, D., Giedraitis, V., Grimmer, T., Graff, C., Grünblatt, E., Hanon, O., Hausner, L., Heilmann-Heimbach, S., Holstege, H., Hort, J., Jürgen, D., Kuulasmaa, T., Van Der Lugt, A., Masullo, C., Mecocci, P., Mehrabian, S., De Mendonça, A., Moebus, S., Nacmias, B., Nicolas, G., Olaso, R., Papenberg, G., Parnetti, L., Pasquier, F., Peters, O., Pijnenburg, Y. A. L., Popp, J., Rainero, I., Ramakers, I., Riedel-Heller, S., Scarmeas, N., Scheltens, P., Scherbaum, N., Schneider, A., Seripa, D., Soininen, H., Solfrizzi, V., Spalletta, G., Squassina, A., Van Swieten, J., Tegos, T. J., Tremolizzo, L., Verhey, F., Vyhnalek, M., Wiltfang, J., Boada, M., García-González, P., Puerta, R., Real, L. M., Álvarez, V., Bullido, M. J., Clarimon, J., García-Alberca, J. M., Mir, P., Moreno, F., Pastor, P., Piñol-Ripoll, G., Molina-Porcel, L., Pérez-Tur, J., Rodríguez-Rodríguez, E., Royo, J. L., Sánchez-Valle, R., Dichgans, M. & Rujescu, D., 2022, In: JAMA Neurology. 79, 7, p. 652-663 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Association of Low Plasma Transthyretin Concentration with Risk of Heart Failure in the General Population

    Greve, A. M., Christoffersen, M., Frikke-Schmidt, Ruth, Nordestgaard, Børge & Tybjærg-Hansen, Anne, 2021, In: JAMA Cardiology. 6, 3, p. 258-266

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Association of MGMT and BIN1 genes with Alzheimer's disease risk across sex and APOE ε4 status

    Le Borgne, J., Amouyel, P., Andreassen, O., Frikke-Schmidt, Ruth, Hiltunen, M., Ingelsson, M., Ramirez, A., Rossi, G., Ruiz, A., Sanchez-Juan, P., Sims, R., Sleegers, K., Tsolaki, M., van der Lee, S. J., Williams, J., Lambert, J. C. & Bellenguez, C., 2024, In: Alzheimer's and Dementia. 20, 3, p. 2282-2284 3 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  14. Published

    Association between primary care electrocardiogram markers and Alzheimer's disease

    Isaksen, Jonas L., Ghouse, Jonas, Skov, M. W., Olesen, Morten Steen Salling, Holst, A. G., Pietersen, A., Nielsen, J. B., Maier, A., Graff, C., Gerds, Thomas Alexander, Frikke-Schmidt, Ruth & Kanters, Jørgen K., 2023, In: Journal of the Neurological Sciences. 447, 6 p., 120581.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Are remitted affective disorders and familial risk of affective disorders associated with metabolic syndrome, inflammation and oxidative stress? - A monozygotic twin study

    Ottesen, N. M., Meluken, I., Frikke-Schmidt, Ruth, Plomgaard, Peter Stendahl, Scheike, Thomas, Fernandes, B. S., Berk, M., Poulsen, Henrik Enghusen, Kessing, Lars Vedel, Miskowiak, Kamilla & Vinberg, Maj, 2020, In: Psychological Medicine. 50, 10, p. 1736-1745 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke: Systematic review and meta-analysis of 14 015 stroke cases and pooled analysis of primary biomarker data from up to 60 883 individuals

    Khan, T. A., Shah, T., Prieto, D., Zhang, W., Price, J., Fowkes, G. R., Cooper, J., Talmud, P. J., Humphries, S. E., Sundstrom, J., Hubacek, J. A., Ebrahim, S., Lawlor, D. A., Ben-Shlomo, Y., Abdollahi, M. R., Slooter, A. J. C., Szolnoki, Z., Sandhu, M., Wareham, N., Frikke-Schmidt, R. & 29 others, Tybjærg-Hansen, Anne, Fillenbaum, G., Heijmans, B. T., Katsuya, T., Gromadzka, G., Singleton, A., Ferrucci, L., Hardy, J., Worrall, B., Rich, S. S., Matarin, M., Whittaker, J., Gaunt, T. R., Whincup, P., Morris, R., Deanfield, J., Donald, A., Davey Smith, G., Kivimaki, M., Kumari, M., Smeeth, L., Khaw, K., Nalls, M., Meschia, J., Sun, K., Hui, R., Day, I., Hingorani, A. D. & Casas, J. P., 2013, In: International Journal of Epidemiology. 42, 2, p. 475-492 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Antibody-dependent neutralizing capacity of the SARS-CoV-2 vaccine BNT162b2 with and without previous COVID-19 priming

    Hansen, Cecilie Bo, Jarlhelt, I., Hasselbalch, R. B., Hamm, S. R., Fogh, K., Pries-Heje, M. M., Møller, D. L., Heftdal, Line Dam, Pérez-Alós, L., Sørensen, E., Larsen, M. A. H., Skjødt, Mikkel-Ole, Ostrowski, Sisse Rye, Frikke-Schmidt, Ruth, Bayarri-Olmos, R., Hilsted, Linda, Bundgård, Henning, Nielsen, Susanne Dam, Iversen, Kasper & Garred, Peter, 2021, In: Journal of Internal Medicine. 290, 6, p. 1272-1274

    Research output: Contribution to journal › Letter › Research › peer-review

  18. Published

    Antibody responses and risk factors associated with impaired immunological outcomes following two doses of BNT162b2 COVID-19 vaccination in patients with chronic pulmonary diseases

    Harboe, Z. B., Hamm, S. R., Pérez-Alós, L., Sivapalan, P., Priemé, H., Wilcke, T., Kjeldgaard, P., Shaker, S., Svorre Jordan, A., Møller, D. L., Heftdal, L. D., Madsen, J. R., Bayarri-Olmos, R., Hansen, C. B., Pries-Heje, M. M., Hasselbalch, R. B., Fogh, K., Armenteros, J. J. A., Hilsted, L., Sørensen, E. & 10 others, Lindegaard, Birgitte, Browatzki, A., Biering-Sørensen, Tor, Frikke-Schmidt, Ruth, Ostrowski, Sisse Rye, Iversen, Kasper, Bundgård, Henning, Nielsen, Susanne Dam, Garred, Peter & Jensen , Jens-Ulrik Stæhr , 2022, In: BMJ Open Respiratory Research. 9, 1, 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    An updated Alzheimer hypothesis: Complement C3 and risk of Alzheimer's disease-A cohort study of 95,442 individuals

    Rasmussen, K. L., Nordestgaard, Børge, Frikke-Schmidt, Ruth & Nielsen, S. F., 2018, In: Alzheimer's & Dementia. 14, 12, p. 1589-1601 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Aerobic exercise training lowers platelet reactivity and improves platelet sensitivity to prostacyclin in pre- and postmenopausal women

    Lundberg Slingsby, M. H., Nyberg, M. P., Egelund, J., djc739, djc739, Frikke-Schmidt, Ruth, Kirkby, N. S. & Hellsten, Ylva, 2017, In: Journal of Thrombosis and Haemostasis. 15, 12, p. 2419-2431 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Admission Leukocyte Count is Associated with Late Cardiogenic Shock Development and All-Cause 30-Day Mortality in Patients with St-Elevation Myocardial Infarction

    Klein, A., Wiberg, S., Hassager, Christian, Winther-Jensen, M., Frikke-Schmidt, Ruth, Bang, L. E., Lindholm, M. G., Holmvang, Lene, Moeller-Helgestad, O., Ravn, H. B., Jensen, L. O., Kjærgaard, J., Møller, J. E. & Frydland, M., 2020, In: Shock. 53, 3, p. 299-306 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Adiposity, Dysmetabolic Traits, and Earlier Onset of Female Puberty in Adolescent Offspring of Women With Gestational Diabetes Mellitus: A Clinical Study Within the Danish National Birth Cohort

    Grunnet, Louise Groth, Hansen, S., Hjort, L., Madsen, C. M., Kampmann, F. B., Thuesen, A. C. B., Granstrømi, C., Strøm, M., Maslova, E., Frikke-Schmidt, Ruth, Damm, Peter, Chavarro, J. E., Hu, F. B., Olsen, S. F. & Vaag, A., Dec 2017, In: Diabetes Care. 40, 12, p. 1746-1755 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Adherence to dietary guidelines and risk of dementia: a prospective cohort study of 94 184 individuals

    Kjeldsen, E. W., Thomassen, J. Q., Rasmussen, Katrine Laura, Nordestgaard, Børge, Tybjærg-Hansen, Anne & Frikke-Schmidt, Ruth, 2022, In: Epidemiology and Psychiatric Sciences. 31, e71.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Absolute 10-year risk of dementia by age, sex and APOE genotype: A population-based cohort study

    Rasmussen, K. L., Tybjarg-Hansen, A., Nordestgaard, Børge & Frikke-Schmidt, Ruth, 2018, In: CMAJ. 190, 35, p. E1033-E1041

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    APOE and vascular disease: Sequencing and genotyping in general population cohorts

    Rasmussen, Katrine Laura, Luo, J., Nordestgaard, Børge, Tybjærg-Hansen, Anne & Frikke-Schmidt, Ruth, 2023, In: Atherosclerosis. 385, 9 p., 117218.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    APOE Genotype, ApoE Plasma Levels, Lipid Metabolism, and Cognition in Monozygotic Twins with, at Risk of, and without Affective Disorders

    Sperling, J. D., Frikke-Schmidt, Ruth, Scheike, Thomas, Kessing, Lars Vedel, Miskowiak, Kamilla & Vinberg, Maj, 2024, In: Journal of Clinical Medicine. 13, 8, 16 p., 2361.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    A systematic review and meta-analysis of 130,000 individuals shows smoking does not modify the association of APOE genotype on risk of coronary heart disease

    Holmes, M. V., Frikke-Schmidt, R., Melis, D., Luben, R., Asselbergs, F. W., Boer, J. M. A., Cooper, J., Palmen, J., Horvat, P., Engmann, J., Li, K-W., Onland-Moret, N. C., Hofker, M. H., Kumari, M., Keating, B. J., Hubacek, J. A., Adamkova, V., Kubinova, R., Bobak, M., Khaw, K-T. & 6 others, Nordestgaard, Børge, Wareham, N., Humphries, S. E., Langenberg, C., Tybjærg-Hansen, Anne & Talmud, P. J., Nov 2014, In: Atherosclerosis. 237, 1, p. 5-12 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    A randomised, double-blind, crossover study of the effect of the fluoroquinolone moxifloxacin on glucose levels and insulin sensitivity in young men and women

    Juhl, C. R., Burgdorf, J., Knudsen, C., Lubberding, Anniek Frederike, Veedfald, Simon, Isaksen, Jonas L., Hartmann, Bolette, Frikke-Schmidt, Ruth, Mandrup-Poulsen, Thomas, Holst, Jens Juul, Kanters, Jørgen K. & Torekov, Signe Sørensen, 2023, In: Diabetes, Obesity and Metabolism. 25, 1, p. 98-109

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease

    Amin Al Olama, A., Kote-Jarai, Z., Schumacher, F. R., Wiklund, F., Berndt, S. I., Benlloch, S., Giles, G. G., Severi, G., Neal, D. E., Hamdy, F. C., Donovan, J. L., Hunter, D. J., Henderson, B. E., Thun, M. J., Gaziano, M., Giovannucci, E. L., Siddiq, A., Travis, R. C., Cox, D. G., Canzian, F. & 31 others, Riboli, E., Key, T. J., Andriole, G., Albanes, D., Hayes, R. B., Schleutker, J., Auvinen, A., Tammela, T. L. J., Weischer, M., Stanford, J. L., Ostrander, E. A., Cybulski, C., Lubinski, J., Thibodeau, S. N., Schaid, D. J., Sorensen, K. D., Batra, J., Clements, J. A., Chambers, S., Aitken, J., Gardiner, R. A., Maier, C., Vogel, W., Dörk, T., Brenner, H., Klarskov, P., Nordestgaard, Børge, Røder, Andreas, Frikke-Schmidt, Ruth, Bojesen, Stig Egil & The UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology, T. U. G. P. C. S. C. A. O. U. S. S. O. O., 2013, In: Human Molecular Genetics. 22, 2, p. 408-415 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    A genome-wide association analysis of high-density lipoprotein cholesterol in the population-based KORA study sheds new light on intergenic regions

    Heid, I. M., Boes, E., Mueller, M., Kollerits, B., Lamina, C., Coassin, S., Gieger, C., Doering, A., Klopp, N., Frikke-Schmidt, Ruth, Tybjaerg-Hansen, A., Brandstaetter, A., Luchner, A., Meitinger, T., Wichmann, H. R. & Kronenberg, F., 2008, In: Circulation. Cardiovascular genetics. 1, 1, p. 10-20 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    A composite immune and vascular stress marker in patients newly diagnosed with bipolar disorder and their unaffected first-degree relatives

    Coello, K., Holstad Pedersen, H., Munkholm, Klaus, Lie Kjærstad, H., Stanislaus, S., Ostrowski, Sisse Rye, Faurholt-Jepsen, Maria , Miskowiak, Kamilla, Frikke-Schmidt, Ruth, Vinberg, Maj, Ekstrøm, Claus Thorn, Forman, Julie Lyng & Kessing, Lars Vedel, 2024, In: Brain, Behavior, and Immunity. 118, p. 449-458 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    A common variant in CCDC93 protects against myocardial infarction and cardiovascular mortality by regulating endosomal trafficking of low-density lipoprotein receptor

    Rimbert, A., Dalila, N., Wolters, J. C., Huijkman, N., Smit, M., Kloosterhuis, N., Riemsma, M., Van Der Veen, Y., Singla, A., Van Dijk, F., Frikke-Schmidt, Ruth, Burstein, E., Tybjærg-Hansen, Anne, Van De Sluis, B. & Kuivenhoven, J. A., 2020, In: European Heart Journal. 41, 9, p. 1040-1053 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    APOE and dementia – resequencing and genotyping in 105,597 individuals

    Rasmussen, K. L., Tybjærg-Hansen, Anne, Nordestgaard, Børge & Frikke-Schmidt, Ruth, 2020, In: Alzheimer's and Dementia. 16, 12, p. 1624-1637 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    ABCA7 and risk of dementia and vascular disease in the Danish population

    Kjeldsen, E. W., Tybjærg-Hansen, Anne, Nordestgaard, Børge & Frikke-Schmidt, Ruth, 2018, In: Annals of Clinical and Translational Neurology. 5, 1, p. 41-51 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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ID: 43235093