TY - JOUR

T1 - Atopic respiratory diseases and IgE sensitization are associated with leukocyte subset concentrations in 14,440 blood donors

AU - Mikkelsen, Susan

AU - Boldsen, Jens Kjærgaard

AU - Møller, Bjarne Kuno

AU - Dinh, Khoa Manh

AU - Rostgaard, Klaus

AU - Petersen, Mikkel Steen

AU - Kaspersen, Kathrine Agergård

AU - Pedersen, Ole Birger

AU - Thørner, Lise Wegner

AU - Handgaard, Linda Jenny

AU - Ostrowski, Sisse Rye

AU - Sigsgaard, Torben

AU - Erikstrup, Christian

N1 - Publisher Copyright: © 2021

PY - 2021

Y1 - 2021

N2 - Background and aims: Allergic rhinitis (AR), allergic conjunctivitis (AC), and asthma are characterized by activation of the immune system. The aim of this study was to explore the long-term association between AR, AC, asthma, and specific immunoglobulin E (IgE) and blood platelet and leukocyte differential counts. Material and methods: In the Danish Blood Donor Study, 14,440 participants from Central Denmark Region had platelet and leukocyte differential counts available and completed a questionnaire regarding AR, AC, and asthma. Of these participants, 8485 were tested for IgE to inhalation allergens. Results: The prevalence of AR, AC, asthma, and IgE sensitization was 19%, 15%, 9%, and 29%, respectively. AR, AC, asthma, wheeze, and IgE sensitization was associated with increased blood eosinophil concentration even in IgE sensitized participants who did not report any allergy or asthma. The strongest associations were observed for participants with current disease. We found no differences in eosinophil concentration between months without symptoms and months with symptoms of AR and asthma. Conclusion: AR, AC, asthma, wheezing, and IgE sensitization to inhalation allergens are associated with increased eosinophil concentration. This may reflect a persistent inflammation even in periods without symptomatic disease.

AB - Background and aims: Allergic rhinitis (AR), allergic conjunctivitis (AC), and asthma are characterized by activation of the immune system. The aim of this study was to explore the long-term association between AR, AC, asthma, and specific immunoglobulin E (IgE) and blood platelet and leukocyte differential counts. Material and methods: In the Danish Blood Donor Study, 14,440 participants from Central Denmark Region had platelet and leukocyte differential counts available and completed a questionnaire regarding AR, AC, and asthma. Of these participants, 8485 were tested for IgE to inhalation allergens. Results: The prevalence of AR, AC, asthma, and IgE sensitization was 19%, 15%, 9%, and 29%, respectively. AR, AC, asthma, wheeze, and IgE sensitization was associated with increased blood eosinophil concentration even in IgE sensitized participants who did not report any allergy or asthma. The strongest associations were observed for participants with current disease. We found no differences in eosinophil concentration between months without symptoms and months with symptoms of AR and asthma. Conclusion: AR, AC, asthma, wheezing, and IgE sensitization to inhalation allergens are associated with increased eosinophil concentration. This may reflect a persistent inflammation even in periods without symptomatic disease.

KW - Allergic conjunctivitis

KW - Allergic IgE sensitization

KW - Allergic rhinitis

KW - Asthma

KW - Peripheral blood leukocytes

KW - Platelets

U2 - 10.1016/j.cca.2021.06.015

DO - 10.1016/j.cca.2021.06.015

M3 - Journal article

C2 - 34118238

AN - SCOPUS:85108719939

VL - 520

SP - 139

EP - 146

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

SN - 0009-8981

ER -