Inflammatory biomarkers and cancer: CRP and suPAR as markers of incident cancer in patients with serious nonspecific symptoms and signs of cancer
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Inflammatory biomarkers and cancer : CRP and suPAR as markers of incident cancer in patients with serious nonspecific symptoms and signs of cancer. / Rasmussen, Line Jee Hartmann; Schultz, Martin; Gaardsting, Anne; Ladelund, Steen; Garred, Peter; Iversen, Kasper; Eugen-Olsen, Jesper; Helms, Morten; David, Kim Peter; Kjaer, Andreas; Lebech, Anne-Mette; Kronborg, Gitte.
In: International Journal of Cancer, Vol. 141, 2017, p. 191-199.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Inflammatory biomarkers and cancer
T2 - CRP and suPAR as markers of incident cancer in patients with serious nonspecific symptoms and signs of cancer
AU - Rasmussen, Line Jee Hartmann
AU - Schultz, Martin
AU - Gaardsting, Anne
AU - Ladelund, Steen
AU - Garred, Peter
AU - Iversen, Kasper
AU - Eugen-Olsen, Jesper
AU - Helms, Morten
AU - David, Kim Peter
AU - Kjaer, Andreas
AU - Lebech, Anne-Mette
AU - Kronborg, Gitte
N1 - © 2017 The Authors International Journal of Cancer published by John Wiley & Sons Ltd on behalf of Union for International Cancer Control.
PY - 2017
Y1 - 2017
N2 - In Denmark, patients with serious nonspecific symptoms and signs of cancer (NSSC) are referred to the diagnostic outpatient clinics (DOCs) where an accelerated cancer diagnostic program is initiated. Various immunological and inflammatory biomarkers have been associated with cancer, including soluble urokinase plasminogen activator receptor (suPAR) and the pattern recognition receptors (PRRs) pentraxin-3, mannose-binding lectin, ficolin-1, ficolin-2 and ficolin-3. We aimed to evaluate these biomarkers and compare their diagnostic ability to classical biomarkers for diagnosing cancer in patients with NSSC. Patients were included from the DOC, Department of Infectious Diseases, Copenhagen University Hospital Hvidovre. Patients were given a final diagnosis based on the combined results from scans, blood work and physical examination. Weight loss, Charlson score and previous cancer were registered on admission, and plasma concentrations of biomarkers were measured. The primary outcome was incident cancer within 1 year. Out of 197 patients included, 39 patients (19.8%) were diagnosed with cancer. Patients with cancer were significantly older and had a higher burden of comorbidities and previous cancer diagnoses compared to patients who were not diagnosed with cancer. Previous cancer, C-reactive protein (CRP) and suPAR were significantly associated with newly diagnosed cancer during follow-up in multiple logistic regression analyses adjusted for age, sex and CRP. Neither any of the PRRs investigated nor self-reported weight loss was associated with cancer. In this study, previous cancer, CRP and suPAR were significantly associated with cancer diagnosis in patients with NSSC. Ficolin-1-3, MBL and pentraxin-3 were not associated with cancer.
AB - In Denmark, patients with serious nonspecific symptoms and signs of cancer (NSSC) are referred to the diagnostic outpatient clinics (DOCs) where an accelerated cancer diagnostic program is initiated. Various immunological and inflammatory biomarkers have been associated with cancer, including soluble urokinase plasminogen activator receptor (suPAR) and the pattern recognition receptors (PRRs) pentraxin-3, mannose-binding lectin, ficolin-1, ficolin-2 and ficolin-3. We aimed to evaluate these biomarkers and compare their diagnostic ability to classical biomarkers for diagnosing cancer in patients with NSSC. Patients were included from the DOC, Department of Infectious Diseases, Copenhagen University Hospital Hvidovre. Patients were given a final diagnosis based on the combined results from scans, blood work and physical examination. Weight loss, Charlson score and previous cancer were registered on admission, and plasma concentrations of biomarkers were measured. The primary outcome was incident cancer within 1 year. Out of 197 patients included, 39 patients (19.8%) were diagnosed with cancer. Patients with cancer were significantly older and had a higher burden of comorbidities and previous cancer diagnoses compared to patients who were not diagnosed with cancer. Previous cancer, C-reactive protein (CRP) and suPAR were significantly associated with newly diagnosed cancer during follow-up in multiple logistic regression analyses adjusted for age, sex and CRP. Neither any of the PRRs investigated nor self-reported weight loss was associated with cancer. In this study, previous cancer, CRP and suPAR were significantly associated with cancer diagnosis in patients with NSSC. Ficolin-1-3, MBL and pentraxin-3 were not associated with cancer.
KW - Age Factors
KW - Aged
KW - Biomarkers, Tumor
KW - C-Reactive Protein
KW - Denmark
KW - Female
KW - Humans
KW - Inflammation
KW - Lectins
KW - Male
KW - Mannose-Binding Lectins
KW - Middle Aged
KW - Neoplasms
KW - Receptors, Urokinase Plasminogen Activator
KW - Serum Amyloid P-Component
KW - Sex Characteristics
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1002/ijc.30732
DO - 10.1002/ijc.30732
M3 - Journal article
C2 - 28393357
VL - 141
SP - 191
EP - 199
JO - International Journal of Cancer
JF - International Journal of Cancer
SN - 0020-7136
ER -
ID: 189870642