Effector and regulatory T cells in patients with acute optic neuritis
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Effector and regulatory T cells in patients with acute optic neuritis. / Tsakiri, Anna; Kjærsgaard, Erik; Grigoriadis, Nikolaos; Svane, Inge Marie; Frederiksen, Jette L.
In: Neuroimmunomodulation, Vol. 19, No. 2, 2012, p. 111-20.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Effector and regulatory T cells in patients with acute optic neuritis
AU - Tsakiri, Anna
AU - Kjærsgaard, Erik
AU - Grigoriadis, Nikolaos
AU - Svane, Inge Marie
AU - Frederiksen, Jette L
N1 - Copyright © 2012 S. Karger AG, Basel.
PY - 2012
Y1 - 2012
N2 - Optic neuritis (ON) is an autoimmune acute demyelinating disease of the optic nerve and may occur in patients with confirmed multiple sclerosis (MS) or as a clinically isolated syndrome. T lymphocytes play a central role in the pathogenesis of MS. The phenotype of different T cell subsets is usually characterized by the expression of distinct cell surface receptors such as CD45RA, CD45RO, CCR7, CD27 and CD28. The aim of this study was to characterize the phenotype of distinct subsets of CD4 and CD8 T cells in patients with isolated ON.
AB - Optic neuritis (ON) is an autoimmune acute demyelinating disease of the optic nerve and may occur in patients with confirmed multiple sclerosis (MS) or as a clinically isolated syndrome. T lymphocytes play a central role in the pathogenesis of MS. The phenotype of different T cell subsets is usually characterized by the expression of distinct cell surface receptors such as CD45RA, CD45RO, CCR7, CD27 and CD28. The aim of this study was to characterize the phenotype of distinct subsets of CD4 and CD8 T cells in patients with isolated ON.
U2 - 10.1159/000330242
DO - 10.1159/000330242
M3 - Journal article
C2 - 22248727
VL - 19
SP - 111
EP - 120
JO - NeuroImmunoModulation
JF - NeuroImmunoModulation
SN - 1021-7401
IS - 2
ER -
ID: 40196993