Socioeconomic inequality in cancer in the Nordic countries. A systematic review
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Socioeconomic inequality in cancer in the Nordic countries. A systematic review. / Ammitzbøll, Gunn; Levinsen, Anne Katrine Graudal; Kjær, Trille Kristina; Ebbestad, Freja Ejlebæk; Horsbøl, Trine Allerslev; Saltbæk, Lena; Badre-Esfahani, Sara Koed; Joensen, Andrea; Kjeldsted, Eva; Halgren Olsen, Maja; Dalton, Susanne Oksbjerg.
In: Acta Oncologica, Vol. 61, No. 11, 2022, p. 1317-1331.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Socioeconomic inequality in cancer in the Nordic countries. A systematic review
AU - Ammitzbøll, Gunn
AU - Levinsen, Anne Katrine Graudal
AU - Kjær, Trille Kristina
AU - Ebbestad, Freja Ejlebæk
AU - Horsbøl, Trine Allerslev
AU - Saltbæk, Lena
AU - Badre-Esfahani, Sara Koed
AU - Joensen, Andrea
AU - Kjeldsted, Eva
AU - Halgren Olsen, Maja
AU - Dalton, Susanne Oksbjerg
N1 - Publisher Copyright: © 2022 Acta Oncologica Foundation.
PY - 2022
Y1 - 2022
N2 - Background: Despite structural and cultural similarities across the Nordic countries, differences in cancer survival remain. With a focus on similarities and differences between the Nordic countries, we investigated the association between socioeconomic position (SEP) and stage at diagnosis, anticancer treatment and cancer survival to describe patterns, explore underlying mechanisms and identify knowledge gaps in the Nordic countries Methods: We conducted a systematic review of population based observational studies. A systematic search in PubMed, EMBASE and Medline up till May 2021 was performed, and titles, abstracts and full texts were screened for eligibility by two investigators independently. We extracted estimates of the association between SEP defined as education or income and cancer stage at diagnosis, received anticancer treatment or survival for adult patients with cancer in the Nordic countries. Further, we extracted information on study characteristics, confounding variables, cancer type and results in the available measurements with corresponding confidence intervals (CI) and/or p-values. Results were synthesized in forest plots. Results: From the systematic literature search, we retrieved 3629 studies, which were screened for eligibility, and could include 98 studies for data extraction. Results showed a clear pattern across the Nordic countries of socioeconomic inequality in terms of advanced stage at diagnosis, less favorable treatment and lower cause-specific and overall survival among people with lower SEP, regardless of whether SEP was measured as education or income. Conclusion: Despite gaps in the literature, the consistency in results across cancer types, countries and cancer outcomes shows a clear pattern of systematic socioeconomic inequality in cancer stage, treatment and survival in the Nordic countries. Stage and anticancer treatment explain some, but not all of the observed inequality in overall and cause-specific survival. The need for further studies describing this association may therefore be limited, warranting next step research into interventions to reduce inequality in cancer outcomes. Study registration: Prospero protocol no: CRD42020166296.
AB - Background: Despite structural and cultural similarities across the Nordic countries, differences in cancer survival remain. With a focus on similarities and differences between the Nordic countries, we investigated the association between socioeconomic position (SEP) and stage at diagnosis, anticancer treatment and cancer survival to describe patterns, explore underlying mechanisms and identify knowledge gaps in the Nordic countries Methods: We conducted a systematic review of population based observational studies. A systematic search in PubMed, EMBASE and Medline up till May 2021 was performed, and titles, abstracts and full texts were screened for eligibility by two investigators independently. We extracted estimates of the association between SEP defined as education or income and cancer stage at diagnosis, received anticancer treatment or survival for adult patients with cancer in the Nordic countries. Further, we extracted information on study characteristics, confounding variables, cancer type and results in the available measurements with corresponding confidence intervals (CI) and/or p-values. Results were synthesized in forest plots. Results: From the systematic literature search, we retrieved 3629 studies, which were screened for eligibility, and could include 98 studies for data extraction. Results showed a clear pattern across the Nordic countries of socioeconomic inequality in terms of advanced stage at diagnosis, less favorable treatment and lower cause-specific and overall survival among people with lower SEP, regardless of whether SEP was measured as education or income. Conclusion: Despite gaps in the literature, the consistency in results across cancer types, countries and cancer outcomes shows a clear pattern of systematic socioeconomic inequality in cancer stage, treatment and survival in the Nordic countries. Stage and anticancer treatment explain some, but not all of the observed inequality in overall and cause-specific survival. The need for further studies describing this association may therefore be limited, warranting next step research into interventions to reduce inequality in cancer outcomes. Study registration: Prospero protocol no: CRD42020166296.
KW - Cancer
KW - diagnosis
KW - socioeconomic
KW - survival
KW - treatment
U2 - 10.1080/0284186X.2022.2143278
DO - 10.1080/0284186X.2022.2143278
M3 - Review
C2 - 36369792
AN - SCOPUS:85142179393
VL - 61
SP - 1317
EP - 1331
JO - Acta Oncologica
JF - Acta Oncologica
SN - 1100-1704
IS - 11
ER -
ID: 340537832