The association between low-grade inflammation, iron status and nucleic acid oxidation in the elderly
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The association between low-grade inflammation, iron status and nucleic acid oxidation in the elderly. / Broedbaek, Kasper; Siersma, Volkert Dirk; Andersen, Jon T; Petersen, Morten; Afzal, Shoaib; Hjelvang, Brian; Weimann, Allan; Semba, Richard D; Ferrucci, Luigi; Poulsen, Henrik E.
In: Free Radical Research, Vol. 45, No. 4, 04.2011, p. 409-416.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The association between low-grade inflammation, iron status and nucleic acid oxidation in the elderly
AU - Broedbaek, Kasper
AU - Siersma, Volkert Dirk
AU - Andersen, Jon T
AU - Petersen, Morten
AU - Afzal, Shoaib
AU - Hjelvang, Brian
AU - Weimann, Allan
AU - Semba, Richard D
AU - Ferrucci, Luigi
AU - Poulsen, Henrik E
PY - 2011/4
Y1 - 2011/4
N2 - This study applied a case-control approach to investigate the association between low-grade inflammation, defined by high values within the normal range of C-reactive protein (CRP) and interleukin-6 (IL-6), and urinary markers of nucleic acid oxidation. No differences in excretion of urinary markers of nucleic acid oxidation between cases and controls were found and multivariable linear regression analysis showed no association between urinary markers of nucleic acid oxidation and inflammatory markers. Post-hoc multivariable linear regression analysis showed significant associations between nucleic acid oxidation and various iron status markers and especially a close relationship between nucleic acid oxidation and ferritin. This study shows no association between low-grade inflammation and urinary markers of nucleic acid oxidation in a population of elderly Italian people. The results suggest that low-grade inflammation only has a negligible impact on whole body nucleic acid oxidation, whereas iron status seems to be of great importance.
AB - This study applied a case-control approach to investigate the association between low-grade inflammation, defined by high values within the normal range of C-reactive protein (CRP) and interleukin-6 (IL-6), and urinary markers of nucleic acid oxidation. No differences in excretion of urinary markers of nucleic acid oxidation between cases and controls were found and multivariable linear regression analysis showed no association between urinary markers of nucleic acid oxidation and inflammatory markers. Post-hoc multivariable linear regression analysis showed significant associations between nucleic acid oxidation and various iron status markers and especially a close relationship between nucleic acid oxidation and ferritin. This study shows no association between low-grade inflammation and urinary markers of nucleic acid oxidation in a population of elderly Italian people. The results suggest that low-grade inflammation only has a negligible impact on whole body nucleic acid oxidation, whereas iron status seems to be of great importance.
KW - DNA oxidation
KW - inflammation
KW - iron
KW - 8-hydroxy-2 '-deoxyguanosine
KW - 8-oxo-7,8-dihydro-2 '-deoxyguanosine
KW - 8-oxodG
KW - 8-oxo-7,8-dihydroguanosine
KW - 8-oxoGuo
KW - C-REACTIVE PROTEIN
KW - HELICOBACTER-PYLORI INFECTION
KW - CORONARY-HEART-DISEASE
KW - DNA-DAMAGE
KW - BODY IRON
KW - HEALTHY PEOPLE
KW - STRESS
KW - CANCER
KW - WOMEN
KW - MEN
U2 - 10.3109/10715762.2010.538391
DO - 10.3109/10715762.2010.538391
M3 - Journal article
C2 - 21275071
VL - 45
SP - 409
EP - 416
JO - Free Radical Research
JF - Free Radical Research
SN - 1071-5762
IS - 4
ER -
ID: 34052739