The effects of dietary supplementation with n-3 polyunsaturated fatty acids in patients with rheumatoid arthritis: a randomized, double blind trial
Research output: Contribution to journal › Journal article › Research › peer-review
Abstract. Study objective: To determine the effect of dietary
supplementation with n-3 polyunsaturated fatty acids (n-3 PUFA) on
disease variables in patients with rheumatoid arthritis. Design:
Multicenter, randomized, placebo controlled, double blind. Setting:
Three Danish hospital Departments of Rheumatology. Patients: Fifty-one
patients with active rheumatoid arthritis. Intervention: Random
allocation to 12 weeks of treatment with either six n-3 PUFA capsules
(3–6 g) or six capsules with fat composition as the average Danish diet.
Main results: Significant improvement of morning stiffness and joint
tenderness. No significant effect on the four other assessed clinical
parameters. No serious side effects. Conclusions: Dietary
supplementation with n-3 PUFA in patients with rheumatoid arthritis
improved two out of six patient reported disease parameters. Further
studies are needed to clarify the more precise role of n-3 PUFA in the
treatment of rheumatoid arthritis.
Original language | English |
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Journal | European Journal of Clinical Investigation |
Volume | 22 |
Issue number | 10 |
Pages (from-to) | 687-691 |
Number of pages | 5 |
ISSN | 0014-2972 |
DOIs | |
Publication status | Published - 1992 |
Externally published | Yes |
- Adult, Aged, Arthritis, Rheumatoid, C-Reactive Protein, Double-Blind Method, Fatty Acids, Omega-3, Humans, Middle Aged, Peptide Fragments, Procollagen, Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't
Research areas
ID: 168819452