Type I and III procollagen propeptides in growth hormone-deficient patients: effects of increasing doses of GH
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The effect of increasing doses of growth hormone on collagen synthesis in GH-treated GH-deficient patients was determined in a short-term study. The synthesis of type I and III collagen was estimated by measurements of the carboxyterminal propeptide of type I procollagen and the aminoterminal propeptide of type III procollagen. Type I collagen is mainly found in bone and type III collagen in loose connective tissue. We observed a GH dose dependency of both procollagen propeptides. Serum type I procollagen propeptide was significantly higher following GH doses of 4 and 6 IU/day for 14 days compared with 2 IU/day (normal replacement dose) (p = 0.04). Withdrawal of GH therapy for 14 days resulted in wider variation, but not significantly different from the levels at 2, 4 and 6 IU/day. A dose dependency was found regarding type III procollagen propeptide, showing significantly higher serum concentrations at a GH dose of 4 IU/day compared with 2 IU/day (p = 0.001), and of 6 IU/day compared with 4 IU/day (p = 0.001). Withdrawal of GH therapy resulted in significantly lower type III procollagen propeptide concentrations compared with those at a GH dose of 4 and 6 IU/day (p = 0.03). Serum type III procollagen propeptide increased twice as much as type I procollagen propeptide, by 47 vs 25%, at a GH dose of 6 IU/day compared with 2 IU/day. The differences between the effects on type I and type III collagen may reflect differences in secretion or turn-over rate of collagen in bone and loose connective tissue.(ABSTRACT TRUNCATED AT 250 WORDS)
Original language | English |
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Journal | Acta Endocrinologica |
Volume | 124 |
Issue number | 3 |
Pages (from-to) | 278-82 |
Number of pages | 5 |
ISSN | 0001-5598 |
Publication status | Published - Mar 1991 |
- Adolescent, Adult, Child, Collagen, Dose-Response Relationship, Drug, Female, Growth Hormone, Humans, Male, Peptide Fragments, Procollagen, Radioimmunoassay, Journal Article, Research Support, Non-U.S. Gov't
Research areas
ID: 168533476