CT screening for lung cancer brings forward early disease. The Randomised Danish Lung Cancer Screening Trial (DLCST): Status after five annual screening rounds with low-dose CT
Research output: Contribution to journal › Journal article › Research › peer-review
BackgroundThe effects of low-dose CT screening on disease stage shift, mortality and overdiagnosis are unclear. Lung cancer findings and mortality rates are reported at the end of screening in the Danish Lung Cancer Screening Trial.Methods4104 men and women, healthy heavy smokers/former smokers were randomised to five annual low-dose CT screenings or no screening. Two experienced chest radiologists read all CT scans and registered the location, size and morphology of nodules. Nodules between 5 and 15 mm without benign characteristics were rescanned after 3 months. Growing nodules (>25% volume increase and/or volume doubling time15 mm were referred for diagnostic workup. In the control group, lung cancers were diagnosed and treated outside the study by the usual clinical practice.ResultsParticipation rates were high in both groups (screening: 95.5%; control: 93.0%; p
Original language | English |
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Journal | Thorax |
Volume | 67 |
Issue number | 4 |
Pages (from-to) | 296-301 |
ISSN | 0040-6376 |
DOIs | |
Publication status | Published - 2012 |
ID: 34051809