COVID-19 causes patient trajectories that are sudden, unpredictable and imbedded in a worldwide panic as well as lack of medical experience and knowledge. This study aims to understand how close family members to patients hospitalized with COVID-19 are affected by the situation. Individual, in-depth interviews with twelve close family members to patients hospitalized with COVID-19 were conducted. The interviews were analyzed with a hermeneutic approach using reflexive methodology. Theoretical conceptualization ensured a critical interpretation. Three empirical themes were identified: fear and unpredictability, not being able to be there and being the “key caregiver”. Family members´ fear is compounded as the whole world is preoccupied with the same fear and uncertainty about COVID-19. Due to the volatile situation, a shift in coping strategies throughout the trajectory was illuminated as well as an ambivalence towards the health system´s treatment regime on COVID-19 implying a total separation between the patient and their close family member. In conclusion, close family members of patients hospitalized with COVID-19 are in a vulnerable situation, characterized by a high degree of unpredictability and seriousness causing fear of losing their loved ones, as well as powerlessness due to visiting restrictions. Hospitalization with COVID-19 is an unpredictable situation, where the family members are separated from their loved ones. Family members are dependent on the communication with health care professionals. Therefore, talking to family members during COVID-19 must be prioritized and it is found necessary to develop relevant and systematic practices for communication and collaboration practices.