Filip Krag Knop

Filip Krag Knop

Clinical Professor

Member of:

  • Internal Medicine: Endocrinology


  1. 2019
  2. Published

    Bariatric surgery in patients with non-alcoholic fatty liver disease from pathophysiology to clinical effects

    Laursen, T. L., Hagemann, C. A., Wei, C., Kazankov, K., Thomsen, K. L., Knop, Filip Krag & Gronbaek, H., 2019, In: World Journal of Hepatology. 11, 2, p. 138-149

    Research output: Contribution to journalReviewResearchpeer-review

  3. Published

    Extrapancreatic glucagon: Present status

    Lund, A. & Knop, Filip Krag, 2019, In: Diabetes Research and Clinical Practice. 147, p. 19-28

    Research output: Contribution to journalReviewResearchpeer-review

  4. Published

    The effects of dual GLP-1/GIP receptor agonism on glucagon secretion: a review

    Mathiesen, D. S., Bagger, J. I., Bergmann, N. C., Lund, A., Christensen, Mikkel Bring, Vilsbøll, Tina & Knop, Filip Krag, 2019, In: International Journal of Molecular Sciences. 20, 17, 18 p., 4092.

    Research output: Contribution to journalReviewResearchpeer-review

  5. Published

    Management of people with Type 2 diabetes shared between a specialized outpatient clinic and primary health care is noninferior to management in a specialized outpatient clinic: a randomized, noninferiority trial

    Munch, L., Bennich, B. B., Overgaard, D., Konradsen, H., Middelfart, H., Kaarsberg, N., Knop, Filip Krag, Vilsbøll, Tina & Røder, M. E., 2019, In: Diabetic Medicine. 36, 7, p. 854-861

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Plasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease

    Niu, Lili, Geyer, P. E., Albrechtsen, Nicolai Jacob Wewer, Gluud, Lise Lotte, Santos, A., Doll, S., Treit, P. V., Holst, Jens Juul, Knop, Filip Krag, Vilsbøll, Tina, Junker, A., Sachs, S., Stemmer, K., Müller, T. D., Tschöp, M. H., Hofmann, S. M. & Mann, Matthias, 2019, In: Molecular Systems Biology. 15, 16 p., e8793.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Plasma proteome profiling discovers potential biomarkers of non-alcoholic fatty liver disease

    Niu, Lili, Gupta, R., Geyer, P. E., Albrechtsen, Nicolai Jacob Wewer, Gluud, Lise Lotte, Santos, A., Doll, S., Holst, Jens Juul, Knop, Filip Krag, Vilsbøll, Tina, Junker, A., Sachs, S., Stemmer, K., Mueller, T. D., Tschoep, M. H., Hofmann, S. M. & Mann, Matthias, Aug 2019, In: Molecular & Cellular Proteomics. 18, 8, p. S71 1 p.

    Research output: Contribution to journalConference abstract in journalResearch

  8. Published

    Gastrin secretion in normal subjects and diabetes patients is inhibited by glucagon-like peptide 1: a role in the gastric side effects of GLP-1-derived drugs?

    Rehfeld, Jens Frederik, Knop, Filip Krag & Asmar, M., 2019, In: Scandinavian Journal of Gastroenterology. 54, 12, p. 1448-1451 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Clinical translatability of a diet-induced obese mouse model of non-alcoholic steatohepatitis

    Rigbolt, K., Veidal, S., Suppli, M., Eriksen, P. L., Feigh, M., Knop, Filip Krag, Gronbaek, H., Thomsen, K. L., Jelsing, J. & Vrang, N., 2019, In: Journal of Hepatology. 70, 1, p. E544 1 p.

    Research output: Contribution to journalConference abstract in journalResearch

  10. Published

    Glucagon-like peptide-1 receptor agonists for antipsychotic-associated cardio-metabolic risk factors: a systematic review and individual participant data meta-analysis

    Siskind, D., Hahn, M., Correll, C. U., Fink-Jensen, Anders, Russell, A. W., Bak, N., Broberg, B. V., Larsen, J., Ishoy, P. L., Vilsbøll, Tina, Knop, Filip Krag, Kisely, S. & Ebdrup, Bjørn, 2019, In: Diabetes, Obesity and Metabolism. 21, 2, p. 293-302 10 p.

    Research output: Contribution to journalReviewResearchpeer-review

  11. Published

    Endogenous glucose-dependent insulinotropic polypeptide exerts diverging and tissue specific in obese patients with type 2 diabetes

    Stensen, S., Gasbjerg, Lærke Smidt, Krogh, L. L., wbf943, wbf943, Skov-Jeppesen, Kirsa, Jensen, M. H., Hartmann, Bolette, Vilsbøll, Tina, Holst, Jens Juul, Rosenkilde, Mette, Christensen, M. B. & Knop, Filip Krag, 2019, In: Diabetologia. 62, Supl. 1/SI, p. S270-S271 2 p., 560.

    Research output: Contribution to journalConference abstract in journalResearch

  12. Published

    Hepatic transcriptome signatures in patients with varying degrees of nonalcoholic fatty liver disease compared with healthy normal-weight individuals

    Suppli, M. P., Rigbolt, K. T. G., Veidal, S. S., Heeboll, S., Eriksen, P. L., Demant, M., Bagger, J. I., Nielsen, J. C., Oro, D., Thrane, S. W., Lund, A., Strandberg, C., Konig, M. J., Vilsbøll, Tina, Vrang, N., Thomsen, K. L., Gronbaek, H., Jelsing, J., Hansen, H. H. & Knop, Filip Krag, 2019, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 316, 4, p. G462-G472 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Lean Women with Polycystic Ovary Syndrome and Insulin Resistance Have Normal Incretin Effect, which Is Unaffected by Metformin Therapy

    Vedtofte, L., Foghsgaard, S., Zierau, L., Vilsbøll, Tina & Knop, Filip Krag, 2019, In: Diabetes. 68, Supplement 1, 1 p., 1186-P.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  14. Published

    The liver-alpha cell axis and type 2 diabetes

    Albrechtsen, Nicolai Jacob Wewer, Pedersen, Jens, Galsgaard, Katrine Douglas, Winther-Sørensen, Marie, Suppli, M. P., Janah, L., Gromada, J., Vilstrup, H., Knop, Filip Krag & Holst, Jens Juul, 2019, In: Endocrine Reviews. 40, 5, p. 1353-1366

    Research output: Contribution to journalReviewResearchpeer-review

  15. Published

    A role for exogenous GLP-1 in the management of postprandial hypoglycaemia after Roux-en-Y gastric bypass?

    Øhrstrøm, C. C. & Knop, Filip Krag, 2019, In: European Journal of Endocrinology. 181, 3, p. C5-C8

    Research output: Contribution to journalComment/debateResearch

  16. 2018
  17. Published

    Glucagon-like peptide 1 in health and disease

    Andersen, A., Lund, A., Knop, Filip Krag & Vilsbøll, Tina, 2018, In: Nature Reviews Endocrinology. 14, p. 390-403

    Research output: Contribution to journalReviewResearchpeer-review

  18. Published

    Is glucagon‐like peptide‐1 fully protected by the dipeptidyl peptidase 4 inhibitor sitagliptin when administered to patients with type 2 diabetes?

    Andersen, E. S., Lund, A., Bagger, J. I., Andreasen, C., Grøndahl, M., Deacon, Carolyn F., Hartmann, Bolette, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, Aug 2018, In: Diabetes, Obesity and Metabolism. 20, 8, p. 1937-1943

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Diverse hepatic microbial DNA fingerprints in healthy lean and obese steatotic humans

    Bagger, J. I., Suppli, M. P., Nielsen, T., Lelouvier, B., Broha, A., Demant, M., Konig, M. J., Strandberg, C., Lund, A., Vilsbøll, Tina & Knop, Filip Krag, 2018, In: Diabetologia. 61, p. S120-S121

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  20. Published

    Metformin er en mulig glukagonlignende peptid-1-stimulator

    Bahne, E., Brønden, A., Vilsbøll, Tina & Knop, Filip Krag, 2018, In: Ugeskrift for Laeger. 180, 12, 4 p., V07170516.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Metformin-induced glucagon-like peptide-1 secretion contributes to the actions of metformin in type 2 diabetes

    Bahne, E., Sun, E. W. L., Young, R. L., Hansen, M., Sonne, D. P., Hansen, J. S., Rohde, U., Liou, A. P., Jackson, M. L., de Fontgalland, D., Rabbitt, P., Hollington, P., Sposato, L., Due, S., Wattchow, D. A., Rehfeld, Jens Frederik, Holst, Jens Juul, Keating, D. J., Vilsbøll, Tina & Knop, Filip Krag, 2018, In: JCI Insight. 3, 23, p. 1-16 e93936.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Cardiovascular biomarkers in clinical studies of type 2 diabetes

    Baldassarre, M. P. A., Andersen, A., Consoli, A., Knop, Filip Krag & Vilsbøll, Tina, 2018, In: Diabetes, Obesity and Metabolism. 20, 6, p. 1350-1360

    Research output: Contribution to journalReviewResearchpeer-review

  23. Published

    Mono- and co-activation of the GIP and GLP-1 receptors inhibits bone resorption

    Bergmann, N. C., Lund, A., Heimburger, S. M., Gasbjerg, Lærke Smidt, Jørgensen, Niklas Rye, Jessen, L., Hartmann, Bolette, Holst, Jens Juul, Christensen, Mikkel Bring, Vilsbøll, Tina & Knop, Filip Krag, 2018, In: Diabetologia. 61, S.1, p. S348-S348 717.

    Research output: Contribution to journalConference abstract in journalResearch

  24. Published

    HYPOGLYCAEMIC EPISODES EVALUATED BY CONTINUOUS GLUCOSE MONITORING IN PATIENTS WITH TYPE 2 DIABETES AND DIALYSIS-DEPENDENT END-STAGE RENAL DISEASE RANDOMISED TO 12-WEEK LIRAGLUTIDE OR PLACEBO TREATMENT

    Bomholt, T., Idorn, T., Knop, Filip Krag, Jorgensen, M. B., Resuli, M., Christensen, Karl Bang, Hansen, P. M., Borg, Rikke, Persson, F., Feldt-Rasmussen, Bo & Hornum, Mads, May 2018, In: Nephrology Dialysis Transplantation. 33, suppl_1, p. 492-492 SP426.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  25. Published

    Restoration of enteroendocrine and pancreatic function after internal hernia and short bowel syndrome in a young woman with gastric bypass: a 2-year follow-up

    Borghede, M., Vinter-Jensen, L., Rasmussen, H. H., Veedfald, Simon, Rehfeld, Jens Frederik, Hartmann, Bolette, Holst, Jens Juul, Knop, Filip Krag & Sonne, D. P., 2018, In: Physiological Reports. 6, 9, 6 p., e13686.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Glucose-lowering effects and mechanisms of the bile acid-sequestering resin sevelamer

    Brønden, A., Mikkelsen, K., Sonne, D. P., Hansen, M., Våben, C., Gabe, M. N., Rosenkilde, Mette, Tremaroli, V., Wu, H., Bäckhed, F., Rehfeld, Jens Frederik, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, Jul 2018, In: Diabetes, Obesity and Metabolism. 20, 7, p. 1623-1631

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    The bile acid-sequestering resin sevelamer eliminates the acute GLP-1 stimulatory effect of endogenously released bile acids in patients with type 2 diabetes

    Brønden, A., Albér, A., Rohde, U., Gasbjerg, Lærke Smidt, Rehfeld, Jens Frederik, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 1 Feb 2018, In: Diabetes, Obesity and Metabolism. 20, 2, p. 362-369

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Glimepiride monotherapy versus combination of glimepiride and linagliptin therapy in patients with HNF1A-diabetes: a protocol for a randomised, double-blinded, placebo-controlled trial

    Christensen, A. S., Storgaard, H., Hædersdal, S., Hansen, Torben, Knop, Filip Krag & Vilsbøll, Tina, 2018, In: BMJ Open. 8, p. 1-9 e022517.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Glucose-Dependent Insulinotropic Polypeptide (GIP) Inhibits Bone Resorption Independently of Insulin and Glycemia

    Christensen, Mikkel Bring, Lund, A., Calanna, S., Jørgensen, Niklas Rye, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 1 Jan 2018, In: The Journal of clinical endocrinology and metabolism. 103, 1, p. 288-294

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Effects of glucagon-like peptide-1 receptor agonists on cardiovascular risk factors: A narrative review of head-to-head comparisons

    Dalsgaard, N. B., Vilsbøll, Tina & Knop, Filip Krag, Mar 2018, In: Diabetes, Obesity and Metabolism. 20, 3, p. 508-519

    Research output: Contribution to journalReviewResearchpeer-review

  31. Published

    Determinants of Fasting Hyperglucagonemia in Patients with Type 2 Diabetes and Nondiabetic Control Subjects

    Demant, M., Bagger, J. I., Suppli, M. P., Lund, A., Gyldenløve, M., Hansen, K. B., Hare, Kristine Juul, Christensen, Mikkel Bring, Sonne, D. P., Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, Dec 2018, In: Metabolic Syndrome and Related Disorders. 16, 10, p. 530-536 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Guanylin and uroguanylin mRNA expression is increased following Roux-en-Y gastric bypass, but guanylins do not play a significant role in body weight regulation and glycemic control

    Fernandez-Cachon, M. L., Pedersen, S. L., Rigbolt, K. T., Zhang, C., Fabricius, K., Hansen, H. H., Elster, L., Fink, L. N., Schäfer, M., Rhee, N. A., Langholz, E., Wandall, E., Friis, S. U., Vilmann, P., Kristiansen, V. B., Schmidt, C., Schreiter, K., Breitschopf, K., Hübschle, T., Jorsal, T. & 6 others, Vilsbøll, Tina, Schmidt, T., Theis, S., Knop, Filip Krag, Larsen, P. J. & Jelsing, J., Mar 2018, In: Peptides. 101, p. 32-43 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Postprandial effects of individual and combined GIP and GLP-1 receptor antagonism in healthy subjects

    Gasbjerg, Lærke Smidt, Helsted, M. M., wbf943, wbf943, Lanng, A. R., Stensen, S., Jakobsen, M. H., Hartmann, Bolette, Christensen, Mikkel Bring, Holst, Jens Juul, Vilsbøll, Tina, Rosenkilde, M. M. & Knop, Filip Krag, 2018, In: Diabetologia. 61, S1, p. S246-S246 503.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  34. Published
  35. Published

    Glucose-dependent insulinotropic polypeptide (GIP) receptor antagonists as anti-diabetic agents

    Gasbjerg, Lærke Smidt, Gabe, M. B. N., Hartmann, Bolette, Christensen, Mikkel Bring, Knop, Filip Krag, Holst, Jens Juul & Rosenkilde, Mette, Feb 2018, In: Peptides. 100, p. 173-181

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Effects of Smoking Versus Nonsmoking on Postprandial Glucose Metabolism in Heavy Smokers Compared With Nonsmokers

    Grøndahl, M. F., Bagger, J. I., Lund, A., Faurschou, A., Rehfeld, Jens Frederik, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, Jun 2018, In: Diabetes Care. 41, 6, p. 1260-1267

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Model-Based Prediction of Plasma Concentration and Enterohepatic Circulation of Total Bile Acids in Humans

    Guiastrennec, B., Sonne, David Peick, Bergstrand, M., Vilsbøll, Tina, Knop, Filip Krag & Karlsson, M. O., 2018, In: C P T: Pharmacometrics & Systems Pharmacology. 7, 9, p. 603-612

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Individual and combined glucose-lowering effects of glucagon receptor antagonism and sodium-glucose cotransporter 2 inhibition

    Haedersdal, S., Lund, A., Maagensen, H., Nielsen-Hannerup, E., Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, 2018, p. S312-S312.

    Research output: Contribution to conferencePosterResearch

  39. Published

    The role of the incretins in the postprandial bone remodelling

    Helsted, M. M., Gasbjerg, Lærke Smidt, Lanng, A. R., Stensen, S., Hartmann, Bolette, Christensen, Mikkel Bring, Holst, Jens Juul, Vilsbøll, Tina, Rosenkilde, M. M. & Knop, Filip Krag, 2018, In: Diabetologia. 61, S1, p. S221-S221 449.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  40. Published

    The Role of Glucagon in the Pathophysiology and Treatment of Type 2 Diabetes

    Hædersdal, S., Lund, A., Knop, Filip Krag & Vilsbøll, Tina, 2018, In: Mayo Clinic Proceedings. 93, 2, p. 217-239

    Research output: Contribution to journalReviewResearchpeer-review

  41. Published

    Protocol for Meal-time Administration of Exenatide for Glycaemic Control in Type 1 Diabetes Cases (The MAG1C trial): A randomised, double-blinded, placebo-controlled trial

    Johansen, N. J., Dejgaard, T. F., Lund, A., Vilsbøll, Tina, Andersen, H. U. & Knop, Filip Krag, 2018, In: BMJ Open. 8, 6, 8 p., 021861.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Enteroendocrine K and L cells in healthy and type 2 diabetic individuals

    Jorsal, T., Rhee, N. A., Pedersen, Jens, Wahlgren, C. D., Mortensen, B., Jepsen, Sara Lind, Jelsing, J., Dalbøge, L. S., Vilmann, Peter, Hassan, H., Hendel, J. W., Poulsen, Steen Seier, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 1 Feb 2018, In: Diabetologia. 61, 2, p. 284-294 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    A gut feeling about glucagon: Eje Prize 2018

    Knop, Filip Krag, 2018, In: European Journal of Endocrinology. 178, 6, p. R267-R280 14 p.

    Research output: Contribution to journalReviewResearchpeer-review

  44. Published

    Differences Between Randomized Clinical Trial Patients and Real-World Initiators of the Glucagon-Like Peptide 1 Receptor Agonist Liraglutide

    Knudsen, J. S., Thomsen, R. W., Pottegård, A., Knop, Filip Krag & Sørensen, H. T., 2018, In: Diabetes Care. 41, 9, p. e133-e135 3 p.

    Research output: Contribution to journalLetterResearchpeer-review

  45. Published

    The Effect of Ethanol on Inflammation Markers and FGF-21 in Healthy Individuals

    Lanng, A. R., Gasbjerg, Lærke Smidt, Bergmann, N. C., Møller, H., Gillum, M., Gronbaek, H., Vilsbøll, Tina & Knop, Filip Krag, 2018, In: Diabetes. 67, Supplement 1, 2415-PUB.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Changes in oxidative RNA and DNA modifications following one-week treatment with sevelamer: two randomized, placebo-controlled trials

    Larsen, E. L., Brønden, A., Karstoft, K., Henriksen, T., Vilsbøll, Tina, Poulsen, Henrik Enghusen & Knop, Filip Krag, 2018, In: Free Radical Biology and Medicine. 128, p. S118 280.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  47. Published

    Changes in urinary excretion of oxidative nucleic acid modifications in the week following Copenhagen Marathon 2018, Denmark

    Larsen, E. L., Kjær, L. K., Michaelsen, C., Andersen, E., Lyngbæk, M., Petersen-bønding, C., Henriksen, T., Vilsbøll, Tina, Knop, Filip Krag, Ploug, Thorkil, Poulsen, Henrik Enghusen & Karstoft, K., 2018, In: Free Radical Biology and Medicine. 128, S1, p. S54

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  48. Published

    Adaptive changes in pancreas post Roux-en-Y gastric bypass induced weight loss

    Lautenbach, A., Wernecke, M., Riedel, N., Veigel, J., Yamamura, J., Keller, S., Jung, R., Busch, P., Mann, O., Knop, Filip Krag, Holst, Jens Juul, Meier, J. J. & Aberle, J., Oct 2018, In: Diabetes - Metabolism: Research and Reviews (Print Edition). 34, 7, p. 1-8 e3025.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Individual and combined glucose-lowering effects of glucagon receptor antagonism and dipeptidyl peptidase-4 inhibition

    Maagensen, H., Haedersdal, S., Lund, A., Nielsen-Hannerup, E., Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, 2018, In: Diabetologia. 61, p. S246-S247

    Research output: Contribution to journalConference abstract in journalResearch

  50. Published

    Bone Turnover Markers in Patients With Nonalcoholic Fatty Liver Disease and/or Type 2 Diabetes During Oral Glucose and Isoglycemic Intravenous Glucose

    Maagensen, H., Junker, A. E., Jorgensen, N. R., Gluud, Lise Lotte, Knop, Filip Krag & Vilsbøll, Tina, 2018, In: Journal of Clinical Endocrinology & Metabolism. 103, 5, p. 2042-2049 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published
  52. Published

    High intensity interval training improves insulin sensitivity in individuals with prediabetes

    Mensberg, P., Frandsen, C., Espersen, E., Leineweber, T., Storgaard, H., Schlawitz, K. S., Petersen, T. H. D., Poulsen, J. N., Sørensen, F., Forman, Julie Lyng, Knop, Filip Krag & Vilsbøll, Tina, 2018, In: Diabetologia. 61, Supplement 1, p. S217-S218 2 p., 441.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

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