Flemming Pociot

Flemming Pociot

Clinical Professor

Member of:

  • Internal Medicine: Endocrinology


  1. 2019
  2. Published

    Capturing residual beta cell function in type 1 diabetes

    Pociot, Flemming, 2019, In: Diabetologia. 62, 1, p. 28-32 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Linking glycemic dysregulation in diabetes to symptoms, comorbidities, and genetics through EHR data mining

    Kirk, I. K., Simon, C., Banasik, K., Holm, P. C., Haue, A. D., Jensen, P. B., Jensen, L. J., Rodriguez, C. L., Pedersen, M. K., Eriksson, R., Andersen, H. U., Almdal, T., Bork-Jensen, J., Grarup, N., Borch-Johnsen, K., Pedersen, O., Pociot, F., Hansen, T., Bergholdt, R., Rossing, P. & 1 others, Brunak, Søren, 2019, In: eLife. 8, 19 p., e44941.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Perinatal Whole Blood Zinc Status and Cytokines, Adipokines, and Other Immune Response Proteins

    Kyvsgaard, J. N., Ellervik, Christina, Lindkvist, E. B., Pipper, C. B., Pociot, Flemming, Svensson, Jannet & Thorsen, S. U., 2019, In: Nutrients. 11, 11 p., 1980.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Transcriptome landscape of protein-coding genes and long noncoding RNAs in the colon and blood of DSS-induced mouse model of Acute ulcerative colitis

    Yarani, R., Palasca, Oana, Doncheva, Nadezhda Tsankova, Anthon, Christian, Pilecki, B., Litman, Thomas, Holmskov, U., Jensen, Lars Juhl, Gorodkin, Jan & Pociot, Flemming, 2019, In: Journal of Crohn's and Colitis. 13, p. S129-S130

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  6. 2018
  7. Published

    MicroRNAs and histone deacetylase inhibition-mediated protection against inflammatory β-cell damage

    Vestergaard, A. L., Bang-Berthelsen, C. H., Floyel, T., Stahl, J. L., Christen, L., Sotudeh, F. T., Horskjaer, P. D. H., Frederiksen, K. S., Kofod, F. G., Bruun, C., Berchtold, L. A., Storling, J., Regazzi, R., Kaur, S., Pociot, Flemming & Mandrup-Poulsen, Thomas, 27 Sep 2018, In: PLOS ONE. 13, 9, p. 1-22 22 p., e0203713 .

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Hepatitis B virus suppresses the secretion of insulin-like growth factor binding protein 1 to facilitate anti-apoptotic IGF-1 effects in HepG2 cells

    Nielsen, K. O., Mirza, A. H., Kaur, S., Jacobsen, K. S., Winther, T. N., Glebe, D., Pociot, Flemming, Høgh, Birthe & Størling, J., 15 Sep 2018, In: Experimental Cell Research. 370, 2, p. 399-408 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    25-hydroxyvitamin D, autoantigenic and total antibody concentrations: Results from a Danish case-control study of newly diagnosed patients with childhood type 1 diabetes and their healthy siblings

    Thorsen, S. U., Pipper, C. B., Johannesen, Jesper, Mortensen, H. B., Pociot, Flemming & Svensson, Jannet, 2018, In: Scandinavian Journal of Immunology. 87, 1, p. 46-53 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Abnormal islet sphingolipid metabolism in type 1 diabetes

    Holm, L. J., Krogvold, L., Hasselby, Jane Preuss, Kaur, S., Claessens, L. A., Russell, M. A., Mathews, C. E., Hanssen, K. F., Morgan, N. G., Koeleman, B. P. C., Roep, B. O., Gerling, I. C., Pociot, Flemming, Dahl-Jørgensen, K. & Buschard, K., 2018, In: Diabetologia. 61, 7, p. 1650-1661 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Bone Mineral Density Is Increased in 276 Danish Children and Adolescents with Type-1-Diabetes

    Madsen, J. O. B., Herskin, C. W., Zerahn, B., Olsen, B. S., Pociot, Flemming & Johannesen, Jesper, 2018, ESPE Abstracts. Bioscientifica, Vol. 89. p. 113 (Hormone Research in Paediatrics).

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

  12. Published

    Cell Type-Selective Expression of Circular RNAs in Human Pancreatic Islets

    Kaur, S., Mirza, A. H. & Pociot, Flemming, 2018, In: Non-coding RNA. 4, 4, 20 p., 38.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Hepatitis B virus upregulates host microRNAs that target apoptosis-regulatory genes in an in vitro cell model

    Nielsen, K. O., Jacobsen, K. S., Mirza, A. H., Winther, T. N., Størling, J., Glebe, D., Pociot, Flemming & Høgh, Birthe, 2018, In: Experimental Cell Research. 371, 1, p. 92-103

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Influence of Disease Duration on Circulating Levels of miRNAs in Children and Adolescents with New Onset Type 1 Diabetes

    Samandari, N., Mirza, A. H., Kaur, S., Hougaard, P., Nielsen, L. B., Fredheim, S., Mortensen, H. B. & Pociot, Flemming, 2018, In: Non-coding RNA. 4, 4, 12 p., 35.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Plasma lipid species at type 1 diabetes onset predict residual beta-cell function after 6 months

    Overgaard, A. J., Weir, J. M., Jayawardana, K., Mortensen, H. B., Pociot, Flemming & Meikle, P. J., 2018, In: Metabolomics. 14, 12, 9 p., 158.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    The emerging role of lncrnas in inflammatory bowel disease

    Yarani, R., Mirza, A. H., Kaur, S. & Pociot, Flemming, 2018, In: Experimental and Molecular Medicine. 50, p. 1-14 161.

    Research output: Contribution to journalReviewResearchpeer-review

  17. Published

    miRNAs regulate development and function of regulatory T-cells in recent onset islet autoimmunity in pre-Type 1 diabetes

    Kaur, S. & Pociot, Flemming, 2018, In: Non-Coding RNA Investigation. 2, 5 p., 16.

    Research output: Contribution to journalEditorialResearch

  18. 2017
  19. Published

    Levels of soluble TREM-1 in children with newly diagnosed type 1 diabetes and their siblings without type 1 diabetes: a Danish case-control study

    Thorsen, S. U., Pipper, C. B., Mortensen, H. B., Skogstrand, K., Pociot, Flemming, Johannesen, Jesper, Svensson, Jannet & the Danish Childhood Diabetes Register, T. D. C. D. R., Dec 2017, In: Pediatric Diabetes. 18, 8, p. 749–754

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Type 1 diabetes genome-wide association studies: Not to be lost in translation

    Pociot, Flemming, Dec 2017, In: Clinical and Translational Immunology. 6, 12, 7 p., e162.

    Research output: Contribution to journalReviewResearchpeer-review

  21. Published

    Long non-coding RNAs as novel players in β cell function and type 1 diabetes

    Mirza, A. H., Kaur, S. & Pociot, Flemming, 24 Jul 2017, In: Human Genomics (Online). 11, 10 p., 17.

    Research output: Contribution to journalReviewResearchpeer-review

  22. Published

    25-Hydroxyvitamin D and Peripheral Immune Mediators: Results from Two Nationwide Danish Pediatric Cohorts

    Thorsen, S., Pipper, C., Skogstrand, K., Pociot, Flemming & Svensson, Jannet, Apr 2017, In: Nutrients. 9, 4, 10 p., 365.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Increased mortality in a Danish cohort of young people with Type 1 diabetes mellitus followed for 24 years

    Sandahl, K., Nielsen, L. B., Svensson, Jannet, Johannesen, Jesper, Pociot, Flemming, Mortensen, H. B., Hougaard, P., Broe, R., Rasmussen, M. L., Grauslund, J., Peto, T. & Olsen, B. S., Mar 2017, In: Diabetic Medicine. 34, 3, p. 380–386

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Type 1 Diabetes Candidate Genes Linked to Pancreatic Islet Cell Inflammation and Beta-Cell Apoptosis

    Størling, J. & Pociot, Flemming, 16 Feb 2017, In: Genes. 8, 2, 12 p., 72.

    Research output: Contribution to journalReviewResearchpeer-review

  25. Published

    Neonatal levels of adiponectin, interleukin-10 and interleukin-12 are associated with the risk of developing type 1 diabetes in childhood and adolescence: A nationwide Danish case-control study

    Thorsen, S. U., Pipper, C. B., Eising, S., Skogstrand, K., Hougaard, D. M., Svensson, Jannet & Pociot, Flemming, Jan 2017, In: Clinical Immunology. 174, p. 18–23 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Circulating microRNA levels predict residual beta cell function and glycaemic control in children with type 1 diabetes mellitus

    Samandari, N., Mirza, A. H., Nielsen, L. B., Kaur, S., Hougaard, P., Fredheim, S., Mortensen, H. B. & Pociot, Flemming, 2017, In: Diabetologia. 60, 2, p. 354-363

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    High neonatal blood iron content is associated with the risk of childhood type 1 diabetes mellitus

    Kyvsgaard, J. N., Overgaard, A. J., Thorsen, S. U., Hansen, Thomas Hesselhøj, Pipper, C. B., Mortensen, H. B., Pociot, Flemming & Svensson, Jannet, 2017, In: Nutrients. 9, 11, 10 p., 1221.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Low perinatal zinc status is not associated with the risk of type 1 diabetes in children

    Kyvsgaard, J. N., Overgaard, A. J., Jacobsen, L. D., Thorsen, S. U., Pipper, C. B., Hansen, Thomas Hesselhøj, Husted, Søren, Mortensen, H. B., Pociot, Flemming & Svensson, Jannet, 2017, In: Pediatric Diabetes. 18, 7, p. 637–642 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Pannexin-2-deficiency sensitizes pancreatic beta-cells to cytokine-induced apoptosis in vitro and impairs glucose tolerance in vivo

    Berchtold, L. A., Miani, M., Diep, T. A., Madsen, A. N., Cigliola, V., Colli, M., Miskovic Krivokapic, Jelena, Pociot, Flemming, Eizirik, D. L., Meda, P., Holst, Birgitte, Billestrup, Nils & Storling, J., 2017, In: Molecular and Cellular Endocrinology. 448, p. 108-121 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Survey of 800+ data sets from human tissue and body fluid reveals xenomiRs are likely artifacts

    Kang, W., Bang-Berthelsen, C. H., Holm, A., Houben, A. J. S., Müller, A. H., Thymann, Thomas, Pociot, Flemming, Estivill, X. & Friedländer, M. R., 2017, In: RNA. 23, 4, p. 433-445 13 p.

    Research output: Contribution to journalReviewResearchpeer-review

  31. Published

    The Role of an iNOS Polymorphism at the Post-Diagnosis Diabetes Development in Children with Type 1 Diabetes

    Johannesen, J., Eriksen, V., Andersen, M. L. M., Nielsen, L. B., Svensson, Jannet, Bergholdt, R., Pociot, Flemming & Mortensen, H. B., 2017, In: Journal of Endocrinology and Diabetes Research . 2, 2, 5 p., 100114.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    The identification and functional annotation of RNA structures conserved in vertebrates

    Seemann, Ernst Stefan, Mirza, A. H., Hansen, C., Bang-Berthelsen, C. H., Garde, C., Christensen-Dalsgaard, M., Torarinsson, E., Yao, Z., Workman, C. T., Pociot, Flemming, Nielsen, Henrik, Tommerup, Niels, Ruzzo, W. L. & Gorodkin, Jan, 2017, In: Genome Research. 27, p. 1371-1383 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. 2016
  34. Published

    Metabolomic Biomarkers in the Progression to Type 1 Diabetes

    Overgaard, A. J., Kaur, S. & Pociot, Flemming, Dec 2016, In: Current Diabetes Reports. 16, 5 p., 127.

    Research output: Contribution to journalReviewResearchpeer-review

  35. Published

    GLP-1 Induces Barrier Protective Expression in Brunner's Glands and Regulates Colonic Inflammation

    Bang-Berthelsen, C. H., Holm, T. L., Pyke, C., Simonsen, L., Søkilde, R., Pociot, Flemming, Heller, R. S., Folkersen, L., Kvist, P. H., Jackerott, M., Fleckner, J., Vilien, M., Knudsen, L. B., Heding, A. & Frederiksen, K. S., Sep 2016, In: Inflammatory Bowel Diseases. 22, 9, p. 2078-97 20 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Neonatal vitamin D status is not associated with later risk of type 1 diabetes: results from two large Danish population-based studies

    Jacobsen, Ramune, Thorsen, S. U., Cohen, A. S., Lundqvist, M., Frederiksen, P., Pipper, C. B., Pociot, Flemming, Thygesen, L. C., Ascherio, A., Svensson, Jannet & Heitmann, Berit, Sep 2016, In: Diabetologia. 59, 9, p. 1871-1881 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Potential beneficial effects of a gluten-free diet in newly diagnosed children with type 1 diabetes: a pilot study

    Svensson, Jannet, Sildorf, S. M., Pipper, C. B., Kyvsgaard, J. N., Bøjstrup, J., Pociot, Flemming, Mortensen, H. B. & Buschard, K., 7 Jul 2016, In: SpringerPlus. 5, 8 p., 994.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Effects of the genome on immune regulation in type 1 diabetes

    Pociot, Flemming, Kaur, S. & Nielsen, L. B., Jul 2016, In: Pediatric Diabetes. 17 , S22, p. 37-42 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Genetic risk factors for type 1 diabetes

    Pociot, Flemming & Lernmark, Å., Jun 2016, In: The Lancet. 387, 10035, p. 2331-9 9 p.

    Research output: Contribution to journalReviewResearchpeer-review

  40. Published

    MicroRNAs as regulators of beta-cell function and dysfunction

    Osmai, M., Osmai, Y., Bang-Berthelsen, C. H., Pallesen, E. M. H., Vestergaard, A. L., Novotny, G. W., Pociot, Flemming & Mandrup-Poulsen, Thomas, May 2016, In: Diabetes - Metabolism: Research and Reviews (Print Edition). 32, 4, p. 334–349 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Identification of valid reference genes for microRNA expression studies in a hepatitis B virus replicating liver cell line

    Jacobsen, K. S., Nielsen, K. O., Nordmann Winther, T., Glebe, D., Pociot, Flemming & Høgh, Birthe, 22 Jan 2016, In: BMC Research Notes. 9, p. 1-7 7 p., 38.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    The genetic and regulatory architecture of ERBB3-type 1 diabetes susceptibility locus

    Kaur, S., Mirza, A. H., Brorsson, C. A., Fløyel, T., Størling, Joachim, Mortensen, H. B., Pociot, Flemming & Hvidoere International Study Group, H. I. S. G., 5 Jan 2016, In: Molecular and Cellular Endocrinology. 419, p. 83-91 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    A20 Inhibits β-Cell Apoptosis by Multiple Mechanisms and Predicts Residual β-Cell Function in Type 1 Diabetes

    Fukaya, M., Brorsson, C. A., Meyerovich, K., Catrysse, L., Delaroche, D., Vanzela, E. C., Ortis, F., Beyaert, R., Nielsen, L. B., Andersen, M. L. M., Mortensen, H. B., Pociot, Flemming, van Loo, G., Størling, J. & Cardozo, A. K., Jan 2016, In: Molecular endocrinology (Baltimore, Md.). 30, 1, p. 48-61 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Lipidomic and metabolomic characterization of a genetically modified mouse model of the early stages of human type 1 diabetes pathogenesis

    Overgaard, A. J., Weir, J. M., De Souza, D. P., Tull, D., Haase, C., Meikle, P. J. & Pociot, Flemming, Jan 2016, In: Metabolomics. 12, p. 1-9 9 p., 13.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    A Systematic Comparison of Purification and Normalization Protocols for Quantitative MicroRNA Expressional Profiling in Insulin-Producing Cells

    Vestergaard, A. L., Blankestijn, M., Stahl, J. L., Pallesen, E. M. H., Bang-Berthelsen, C. H., Pociot, Flemming, Novotny, G. W., Lundh, M. & Mandrup-Poulsen, Thomas, 2016, In: International Journal of Molecular Sciences (Online). 17, 6, 8 p., 896.

    Research output: Contribution to journalComment/debateResearchpeer-review

  46. Published

    Genetic Risk Score Modelling for Disease Progression in New-Onset Type 1 Diabetes Patients: Increased Genetic Load of Islet-Expressed and Cytokine-Regulated Candidate Genes Predicts Poorer Glycemic Control

    Brorsson, C. A., Nielsen, L. B., Andersen, M., Kaur, S., Bergholdt, R., Hansen, L., Mortensen, H. B., Pociot, Flemming, Størling, J. & Hvidoere Study Group On Childhood Diabetes, H. S. G. O. C. D., 2016, In: Journal of Diabetes Research. 2016, 8 p., 9570424.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    No Contribution of GAD-65 and IA-2 Autoantibodies around Time of Diagnosis to the Increasing Incidence of Juvenile Type 1 Diabetes: A 9-Year Nationwide Danish Study

    Thorsen, S. U., Pipper, C. B., Mortensen, H. B., Pociot, Flemming, Johannesen, Jesper & Svensson, Jannet, 2016, In: International Journal of Endocrinology. 2016, 7 p., 8350158.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Systematic evaluation of genes and genetic variants associated with type 1 diabetes susceptibility

    Ram, R., Mehta, M., Nguyen, T. Q., Larma, I., Boehm, B. O., Pociot, Flemming, Concannon, P. & Morahan, G., 2016, In: Journal of Immunology. 196, 7, p. 3043-3053 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. 2015
  50. Published

    Genetic Determinants of Enterovirus Infections: Polymorphisms in Type 1 Diabetes and Innate Immune Genes in the MIDIA Study

    Witsø, E., Cinek, O., Tapia, G., Brorsson, C. A., Stene, L. C., Gjessing, H. K., Rasmussen, T., Bergholdt, R., Pociot, Flemming & Rønningen, K. S., Dec 2015, In: Viral Immunology. 28, 10, p. 556-63 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    TYK2, a Candidate Gene for Type 1 Diabetes, Modulates Apoptosis and the Innate Immune Response in Human Pancreatic β-Cells

    Marroqui, L., Dos Santos, R. S., Fløyel, T., Grieco, F. A., Santin, I., Op de Beeck, A., Marselli, L., Marchetti, P., Pociot, Flemming & Eizirik, D. L., Nov 2015, In: Diabetes. 64, 11, p. 3808-17 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Genes affecting β-cell function in type 1 diabetes

    Fløyel, T., Kaur, S. & Pociot, Flemming, Nov 2015, In: Current Diabetes Reports. 15, 11, p. 1-11 15-97.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Polymorphisms in the CTSH gene may influence the progression of diabetic retinopathy: a candidate-gene study in the Danish Cohort of Pediatric Diabetes 1987 (DCPD1987)

    Thorsen, S. U., Sandahl, K., Nielsen, L. B., Broe, R., Rasmussen, M. L., Peto, T., Grauslund, J., Andersen, M. L. M., Mortensen, H. B., Pociot, Flemming, Olsen, B. S. & Brorsson, C., Nov 2015, In: Graefe's Archive for Clinical and Experimental Ophthalmology. 253, 11, p. 1959-65 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Shared Genetic Basis for Type 1 Diabetes, Islet Autoantibodies, and Autoantibodies Associated With Other Immune-Mediated Diseases in Families With Type 1 Diabetes

    Brorsson, C. A., Pociot, Flemming & Type 1 Diabetes Genetics Consortium, T. 1. D. G. C., Oct 2015, In: Diabetes Care. 38, Suppl 2, p. S8-S13

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    Novel Association Between Immune-Mediated Susceptibility Loci and Persistent Autoantibody Positivity in Type 1 Diabetes

    Brorsson, C. A., Onengut, S., Chen, W., Wenzlau, J., Yu, L., Baker, P., Williams, A. J. K., Bingley, P. J., Hutton, J. C., Eisenbarth, G. S., Concannon, P., Rich, S. S., Pociot, Flemming & Type 1 Diabetes Genetics Consortium, T. 1. D. G. C., Aug 2015, In: Diabetes. 64, 8, p. 3017-27 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 922065