Flemming Pociot
Clinical Professor
Department of Clinical Medicine
Blegdamsvej 3
2200 København N.
Member of:
Internal Medicine: Endocrinology
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25-Hydroxyvitamin D and Peripheral Immune Mediators: Results from Two Nationwide Danish Pediatric Cohorts
Thorsen, S., Pipper, C., Skogstrand, K., Pociot, Flemming & Svensson, Jannet, Apr 2017, In: Nutrients. 9, 4, 10 p., 365.Research output: Contribution to journal › Journal article › Research › peer-review
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25-hydroxyvitamin D, autoantigenic and total antibody concentrations: Results from a Danish case-control study of newly diagnosed patients with childhood type 1 diabetes and their healthy siblings
Thorsen, S. U., Pipper, C. B., Johannesen, Jesper, Mortensen, H. B., Pociot, Flemming & Svensson, Jannet, 2018, In: Scandinavian Journal of Immunology. 87, 1, p. 46-53 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Skap2, a candidate gene for type 1 diabetes, regulates b-cell apoptosis and glycemic control in newly diagnosed patients
Fløyel, T., Meyerovich, K., Prause, Michala Cecilie Burstein, Kaur, S., Frørup, C., Mortensen, H. B., Nielsen, L. B., Pociot, Flemming, Cardozo, A. K. & Størling, Joachim, 2021, In: Diabetes. 70, 2, p. 464-476 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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TYK2, a Candidate Gene for Type 1 Diabetes, Modulates Apoptosis and the Innate Immune Response in Human Pancreatic β-Cells
Marroqui, L., Dos Santos, R. S., Fløyel, T., Grieco, F. A., Santin, I., Op de Beeck, A., Marselli, L., Marchetti, P., Pociot, Flemming & Eizirik, D. L., Nov 2015, In: Diabetes. 64, 11, p. 3808-17 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A Dual Systems Genetics Approach Identifies Common Genes, Networks, and Pathways for Type 1 and 2 Diabetes in Human Islets
Kaur, S., Mirza, A. H., Overgaard, A. J., Pociot, Flemming & Størling, Joachim, 2021, In: Frontiers in Genetics. 12, 630109.Research output: Contribution to journal › Journal article › Research › peer-review
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A Gluten-Free Diet during Pregnancy and Early Life Increases Short Chain Fatty Acid-Producing Bacteria and Regulatory T Cells in Prediabetic NOD Mice
Johansen, Valdemar Brimnes Ingemann, Færø, D., Buschard, K., Kristiansen, Karsten, Pociot, Flemming, Kiilerich, P., Josefsen, K., Haupt-jorgensen, M. & Antvorskov, J. C., 2023, In: Cells. 12, 12, 15 p., 1567.Research output: Contribution to journal › Journal article › Research › peer-review
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A Systematic Comparison of Purification and Normalization Protocols for Quantitative MicroRNA Expressional Profiling in Insulin-Producing Cells
Vestergaard, A. L., Blankestijn, M., Stahl, J. L., Pallesen, E. M. H., Bang-Berthelsen, C. H., Pociot, Flemming, Novotny, G. W., Lundh, M. & Mandrup-Poulsen, Thomas, 2016, In: International Journal of Molecular Sciences (Online). 17, 6, 8 p., 896.Research output: Contribution to journal › Comment/debate › Research › peer-review
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A human phenome-interactome network of protein complexes implicated in genetic disorders
Lage, K., Karlberg, E. O., Størling, Z. M., Olason, P. I., Pedersen, A. G., Rigina, O., Hinsby, A. M., Tümer, Asuman Zeynep, Pociot, Flemming, Tommerup, Niels, Moreau, Y. & Brunak, S., 2007, In: Nature Biotechnology. 25, 3, p. 309-16 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3
Concannon, P., Onengut-Gumuscu, S., Todd, J. A., Smyth, D. J., Pociot, Flemming, Bergholdt, R., Akolkar, B., Erlich, H. A., Hilner, J. E., Julier, C., Morahan, G., Nerup, J., Nierras, C. R., Chen, W. M. & Rich, S. S., 2008, In: Diabetes. 57, 10, p. 2858-2861 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A non-synonymous variant in SLC30A8 is not associated with type 1 diabetes in the Danish population
Brorsson, C., Bergholdt, R., Sjogren, M., Eising, S., Sorensen, K. M., Hougaard, D. M., Orho-Melander, M., Groop, L. & Pociot, Flemming, 2008, In: Molecular Genetics and Metabolism. 94, 3, p. 386-388 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A possible association between a dysfunctional skin barrier (filaggrin null-mutation status) and diabetes: a cross-sectional study
Thyssen, Jacob Pontoppidan, Linneberg, Allan René, Carlsen, B. C., Johansen, Jeanne Duus, Engkilde, K., Hansen, Torben, Pociot, Flemming, Pedersen, Oluf Borbye, Meldgaard, M., Szecsi, P. B., Stender, Steen & Menné, T., 1 Jan 2011, In: BMJ Open. 1, 1, p. e000062 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A20 Inhibits β-Cell Apoptosis by Multiple Mechanisms and Predicts Residual β-Cell Function in Type 1 Diabetes
Fukaya, M., Brorsson, C. A., Meyerovich, K., Catrysse, L., Delaroche, D., Vanzela, E. C., Ortis, F., Beyaert, R., Nielsen, L. B., Andersen, M. L. M., Mortensen, H. B., Pociot, Flemming, van Loo, G., Størling, J. & Cardozo, A. K., Jan 2016, In: Molecular endocrinology (Baltimore, Md.). 30, 1, p. 48-61 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Abnormal islet sphingolipid metabolism in type 1 diabetes
Holm, L. J., Krogvold, L., Hasselby, Jane Preuss, Kaur, S., Claessens, L. A., Russell, M. A., Mathews, C. E., Hanssen, K. F., Morgan, N. G., Koeleman, B. P. C., Roep, B. O., Gerling, I. C., Pociot, Flemming, Dahl-Jørgensen, K. & Buschard, K., 2018, In: Diabetologia. 61, 7, p. 1650-1661 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Alu Elements as Novel Regulators of Gene Expression in Type 1 Diabetes Susceptibility Genes?
Kaur, S. & Pociot, Flemming, 2015, In: Genes. 6, 3, p. 577-91 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Anti-diabetic potential of Urtica Dioica: current knowledge and future direction
Chehri, A., Yarani, R., Yousefi, Z., Novin Bahador, T., Shakouri, S. K., Ostadrahimi, A., Mobasseri, M., Pociot, Flemming & Araj-Khodaei, M., 2022, In: Journal of Diabetes and Metabolic Disorders. 21, 1, p. 931-940 10 p.Research output: Contribution to journal › Review › Research › peer-review
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Anti-diabetic potential of plant alkaloids: Revisiting current findings and future perspectives
Rasouli, H., Yarani, R., Pociot, Flemming & Popović-Djordjević, J., May 2020, In: Pharmacological Research. 155, 15 p., 104723.Research output: Contribution to journal › Review › Research › peer-review
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Assisting the implementation of screening for type 1 diabetes by using artificial intelligence on publicly available data
Teixeira, P. F., Battelino, T., Carlsson, A., Gudbjörnsdottir, S., Hannelius, U., von Herrath, M., Knip, M., Korsgren, O., Elding Larsson, H., Lindqvist, A., Ludvigsson, J., Lundgren, M., Nowak, C., Pettersson, P., Pociot, Flemming, Sundberg, F., Åkesson, K., Lernmark, Å. & Forsander, G., 2024, In: Diabetologia. 67, 6, p. 985-994Research output: Contribution to journal › Journal article › Research › peer-review
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Association between Neonatal Whole Blood Iron Content and Cytokines, Adipokines, and Other Immune Response Proteins
Thorsen, S. U., Pipper, C. B., Ellervik, Christina, Pociot, Flemming, Kyvsgaard, J. N. & Svensson, Jannet, 2019, In: Nutrients. 11, 3, 12 p., 543.Research output: Contribution to journal › Journal article › Research › peer-review
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Association of a functional 17beta-estradiol sensitive IL6-174G/C promoter polymorphism with early-onset type 1 diabetes in females
Kristiansen, O. P., Nolsøe, R. L., Larsen, L., Gjesing, A. M. P., Johannesen, J., Larsen, Z. M. E., Lykkesfeldt, A. E., Karlsen, A. E., Pociot, Flemming, Mandrup-Poulsen, Thomas & DIEGG, D., 15 May 2003, In: Human Molecular Genetics. 12, 10, p. 1101-10 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Bone Mineral Density Is Increased in 276 Danish Children and Adolescents with Type-1-Diabetes
Madsen, J. O. B., Herskin, C. W., Zerahn, B., Olsen, B. S., Pociot, Flemming & Johannesen, Jesper, 2018, ESPE Abstracts. Bioscientifica, Vol. 89. p. 113 (Hormone Research in Paediatrics).Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review
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Bone turnover markers during the remission phase in children and adolescents with type 1 diabetes
Madsen, J. O. B., Herskin, C. W., Zerahn, B., Jensen, Andreas Kryger, Jørgensen, Niklas Rye, Olsen, B. S., Svensson, Jannet, Pociot, Flemming & Johannesen, Jesper, 2020, In: Pediatric Diabetes. 21, 2, p. 366-376 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Bone turnover markers in children and adolescents with type 1 diabetes
Madsen, J. O. B., Jørgensen, N. R., Pociot, Flemming & Johannesen, Jesper, 2019, In: Pediatric Diabetes. 20, 5, p. 510-522Research output: Contribution to journal › Review › Research › peer-review
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Breast Milk-Derived Extracellular Vesicles Enriched in Exosomes From Mothers With Type 1 Diabetes Contain Aberrant Levels of microRNAs
Mirza, A. H., Kaur, S., Nielsen, L. B., Størling, J., Yarani, R., Roursgaard, Martin, Mathiesen, Elisabeth, Damm, Peter, Svare, J., Mortensen, H. B. & Pociot, Flemming, 2019, In: Frontiers in Immunology. 10, p. 2543Research output: Contribution to journal › Journal article › Research › peer-review
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CTSH regulates β-cell function and disease progression in newly diagnosed type 1 diabetes patients
Fløyel, T., Brorsson, C., Nielsen, L. B., Miani, M., Bang-Berthelsen, C. H., Friedrichsen, M., Overgaard, A. J., Berchtold, L. A., Wiberg, A., Poulsen, P., Hansen, L., Rosinger, S., Boehm, B. O., Ram, R., Nguyen, Q., Mehta, M., Morahan, G., Concannon, P., Bergholdt, R., Nielsen, J. H. & 7 others, , 15 Jul 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 28, p. 10305-10310 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Capturing residual beta cell function in type 1 diabetes
Pociot, Flemming, 2019, In: Diabetologia. 62, 1, p. 28-32 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cathepsin c regulates cytokine-induced apoptosis in β-cell model systems
Fløyel, T., Frørup, C., Størling, Joachim & Pociot, Flemming, 2021, In: Genes. 12, 11, 1694.Research output: Contribution to journal › Journal article › Research › peer-review
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Cell Type-Selective Expression of Circular RNAs in Human Pancreatic Islets
Kaur, S., Mirza, A. H. & Pociot, Flemming, 2018, In: Non-coding RNA. 4, 4, 20 p., 38.Research output: Contribution to journal › Journal article › Research › peer-review
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Changes in the lipidome in type 1 diabetes following low carbohydrate diet: Post-hoc analysis of a randomized crossover trial
Al-Sari, N., Schmidt, S., Suvitaival, T., Kim, M., Trošt, K., Ranjan, A. G., Christensen, M. B., Overgaard, A. J., Pociot, Flemming, Nørgaard, Kirsten & Legido-Quigley, C., 2021, In: Endocrinology, Diabetes and Metabolism. 4, 2, e00213.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of plasma lipidomics in adolescent subjects with increased risk for type 1 diabetes in the DiPiS cohort
Andersson Svärd, A., Kaur, S., Trôst, K., Suvitaival, T., Lernmark, Å., Maziarz, M., Pociot, Flemming, Overgaard, A. J. & DiPiS Study Group, D. S. G., 2020, In: Metabolomics : Official journal of the Metabolomic Society. 16, 10, 14 p., 10.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of the functional and transcriptomic effects of pro-inflammatory cytokines on human EndoC-βH5 beta cells
Frørup, C., Gerwig, R., Svane, C. A. S., Mendes Lopes de Melo, J., Henriksen, K., Fløyel, T., Pociot, Flemming, Kaur, S. & Størling, Joachim, 2023, In: Frontiers in Endocrinology. 14, 15 p., 1128523.Research output: Contribution to journal › Journal article › Research › peer-review
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Children at onset of type 1 diabetes show altered N-glycosylation of plasma proteins and IgG
Rudman, N., Kifer, D., Kaur, S., Simunović, V., Cvetko, A., Pociot, Flemming, Morahan, G. & Gornik, O., 2022, In: Diabetologia. 65, 8, p. 1315-1327 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Circulating Inflammatory Markers Are Inversely Associated with Heart Rate Variability Measures in Type 1 Diabetes
Wegeberg, A. L., Okdahl, T., Fløyel, T., Brock, C., Ejskjaer, N., Riahi, S., Pociot, Flemming, Størling, Joachim & Brock, Birgitte, 2020, In: Mediators of Inflammation. 2020, 10 p., 3590389.Research output: Contribution to journal › Journal article › Research › peer-review
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Circulating MicroRNAs in Plasma of Hepatitis B e Antigen Positive Children Reveal Liver-Specific Target Genes
Winther, T. N., Jacobsen, K. S., Mirza, A. H., Heiberg, I. L., Bang-Berthelsen, C. H., Pociot, Flemming & Høgh, Birthe, 2014, In: International Journal of Hepatology. 2014, p. 791045Research output: Contribution to journal › Journal article › Research › peer-review
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Circulating microRNA levels predict residual beta cell function and glycaemic control in children with type 1 diabetes mellitus
Samandari, N., Mirza, A. H., Nielsen, L. B., Kaur, S., Hougaard, P., Fredheim, S., Mortensen, H. B. & Pociot, Flemming, 2017, In: Diabetologia. 60, 2, p. 354-363Research output: Contribution to journal › Journal article › Research › peer-review
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Cross-species high-resolution transcriptome profiling suggests biomarkers and therapeutic targets for ulcerative colitis
Yarani, R., Palasca, Oana, Doncheva, Nadezhda Tsankova, Anthon, Christian, Pilecki, B., Svane, C. A. S., Mirza, A. H., Litman, Thomas, Holmskov, U., Bang-Berthelsen, C. H., Vilien, M., Jensen, Lars Juhl, Gorodkin, Jan & Pociot, Flemming, 2023, In: Frontiers in Molecular Biosciences. 9, 1081176.Research output: Contribution to journal › Journal article › Research › peer-review
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Decreased markers of bone turnover in children and adolescents with type 1 diabetes
Madsen, J. O. B., Herskin, C. W., Zerahn, B., Jørgensen, Niklas Rye, Olsen, B. S., Pociot, Flemming & Johannesen, Jesper, 2020, In: Pediatric Diabetes. 21, 3, p. 505-514Research output: Contribution to journal › Journal article › Research › peer-review
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Diabetes complications and extracellular vesicle therapy
Soltani, S., Mansouri, K., Parvaneh, S., Thakor, A. S., Pociot, Flemming & Yarani, R., 2022, In: Reviews in Endocrine and Metabolic Disorders. 23, p. 357–385Research output: Contribution to journal › Review › Research › peer-review
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Differences in insulin sensitivity in the partial remission phase of childhood type 1 diabetes: a longitudinal cohort study
Mørk, F. C. B., Madsen, J. O. B., Jensen, Andreas Kryger, van Hall, Gerrit, Pilgaard, Kasper Ascanius, Pociot, Flemming & Johannesen, Jesper, 2022, In: Diabetic Medicine. 39, 2, 9 p., 14702.Research output: Contribution to journal › Journal article › Research › peer-review
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Differential plasma microRNA profiles in HBeAg positive and HBeAg negative children with chronic hepatitis B
Winther, T. N., Bang-Berthelsen, C. H., Heiberg, I. L., Pociot, Flemming & Høgh, Birthe, 2013, In: PLOS ONE. 8, 3, p. e58236Research output: Contribution to journal › Journal article › Research › peer-review
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Differentially Expressed miRNAs in Ulcerative Colitis and Crohn's Disease
Yarani, R., Shojaeian, A., Palasca, Oana, Doncheva, Nadezhda Tsankova, Jensen, Lars Juhl, Gorodkin, Jan & Pociot, Flemming, 2022, In: Frontiers in Immunology. 13, 21 p., 865777.Research output: Contribution to journal › Review › Research › peer-review
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Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic ß cell fate in response to cytokines
Hansen, J. B., Tonnesen, M. F., Madsen, A. N., Hagedorn, P., Friberg, J., Grunnet, L. G., Heller, R. S., Nielsen, A. Ø., Størling, J., Baeyens, L., Anker-Kitai, L., Qvortrup, K., Bouwens, L., Efrat, S., Aalund, M., Andrews, N. C., Billestrup, N., Karlsen, A. E., Holst, B., Pociot, F. & 1 others, , 2012, In: Cell Metabolism. 16, 4, p. 449-61 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Does rapid sequence divergence preclude RNA structure conservation in vertebrates?
Seemann, Ernst Stefan, Mirza, A. H., Bang-Berthelsen, C. H., Garde, C., Christensen-Dalsgaard, M., Workman, C. T., Pociot, Flemming, Tommerup, Niels, Gorodkin, Jan & Ruzzo, W. L., 2022, In: Nucleic Acids Research. 50, 5, p. 2452-2463 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of the genome on immune regulation in type 1 diabetes
Pociot, Flemming, Kaur, S. & Nielsen, L. B., Jul 2016, In: Pediatric Diabetes. 17 , S22, p. 37-42 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Elevated levels of interleukin-12/23p40 may serve as a potential indicator of dysfunctional heart rate variability in type 2 diabetes
Wegeberg, A. M., Okdahl, T., Riahi, S., Ejskjaer, N., Pociot, Flemming, Størling, Joachim, Brock, Birgitte & Brock, C., 2022, In: Cardiovascular Diabetology. 21, 1, 10 p., 5.Research output: Contribution to journal › Journal article › Research › peer-review
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Expression profiling of human genetic and protein interaction networks in type 1 diabetes
Bergholdt, R., Brorsson, C., Lage, K., Nielsen, Jens Høiriis, Brunak, S. & Pociot, Flemming, 2009, In: PLoS ONE. 4, 7, p. e6250Research output: Contribution to journal › Journal article › Research › peer-review
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Extracellular Vesicle Therapy for Type 1 Diabetes
Soltani, S., Mansouri, K., Emami Aleagha, M. S., Moasefi, N., Yavari, Niloofar, Shakouri, S. K., Notararigo, S., Shojaeian, A., Pociot, Flemming & Yarani, R., 2022, In: Frontiers in Immunology. 13, 865782.Research output: Contribution to journal › Review › Research › peer-review
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Finding diabetic nephropathy biomarkers in the plasma peptidome by high-throughput magnetic bead processing and MALDI-TOF-MS analysis
Hansen, H. G., Overgaard, J., Lajer, M., Hubalek, F., Højrup, P., Pedersen, L., Tarnow, L., Rossing, Peter, Pociot, Flemming & McGuire, J. N., 1 Sep 2010, In: Proteomics - Clinical Applications. 4, 8-9, p. 697-705 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes
Robertson, C. C. & Type 1 Diabetes Genetics Consortium, T. 1. D. G. C., 2021, In: Nature Genetics. 53, 7, p. 962-971 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Functional SOCS1 polymorphisms are associated with variation in obesity in whites
Gylvin, T., Ek, J., Nolsøe, R., Albrechtsen, A., Andersen, G., Bergholdt, R., Brorsson, C., Bang-Berthelsen, C. H., Hansen, T., Karlsen, A. E., Billestrup, N., Borch-Johnsen, K., Jørgensen, T., Pedersen, Oluf Borbye, Mandrup-Poulsen, Thomas, Nerup, J. & Pociot, Flemming, 2009, In: Diabetes, Obesity and Metabolism. 11, 3, p. 196-203 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Functional promoter haplotypes of the human FAS gene are associated with the phenotype of SLE characterized by thrombocytopenia
Nolsøe, R. L., Kelly, J. A., Pociot, Flemming, Moser, K., Kristiansen, O. P., Mandrup-Poulsen, Thomas & Harley, J. B., 1 Dec 2005, In: Genes and Immunity. 6, 8, p. 699-706 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 922065
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Transcriptomic landscape of lncRNAs in inflammatory bowel disease
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Plasma proteome analysis of patients with type 1 diabetes with diabetic nephropathy
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Long non-coding RNAs as novel players in β cell function and type 1 diabetes
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