A primer on metabolic memory: Why existing diabesity treatments fail
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Despite massive government and private sector investments into prevention of cardiovascular disease, diabetes mellitus and obesity, efforts have largely failed, and the burden of cost remains in the treatment of downstream morbidity and mortality, with overall stagnating outcomes. A new paradigm shift in the approach to these patients may explain why existing treatment strategies fail, and offer new treatment targets. This review aims to provide a clinician-centred primer on metabolic memory, defined as the sum of irreversible genetic, epigenetic, cellular and tissue-level alterations that occur with long-time exposure to metabolic derangements.
Original language | English |
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Journal | Clinical Kidney Journal |
Volume | 14 |
Issue number | 3 |
Pages (from-to) | 756-767 |
Number of pages | 12 |
ISSN | 2048-8505 |
DOIs | |
Publication status | Published - 2021 |
Bibliographical note
Publisher Copyright:
© 2020 The Author(s) 2020. Published by Oxford University Press on behalf of ERA-EDTA.
- chronic kidney disease, diabetic kidney disease, epigenetics, metabolic memory, sirtuin 1
Research areas
ID: 304087375