Circulating levels of endothelial progenitor cells are associated with better cognitive function in older adults with glucagon-like peptide 1 receptor agonist-treated type 2 diabetes
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Circulating levels of endothelial progenitor cells are associated with better cognitive function in older adults with glucagon-like peptide 1 receptor agonist-treated type 2 diabetes. / Longo, Miriam; Di Meo, Irene; Caruso, Paola; Muscio, Maria Francesca; Scappaticcio, Lorenzo; Maio, Antonietta; Maiorino, Maria Ida; Bellastella, Giuseppe; Signoriello, Giuseppe; Knop, Filip K.; Rizzo, Maria Rosaria; Esposito, Katherine.
In: Diabetes Research and Clinical Practice, Vol. 200, 110688, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Circulating levels of endothelial progenitor cells are associated with better cognitive function in older adults with glucagon-like peptide 1 receptor agonist-treated type 2 diabetes
AU - Longo, Miriam
AU - Di Meo, Irene
AU - Caruso, Paola
AU - Muscio, Maria Francesca
AU - Scappaticcio, Lorenzo
AU - Maio, Antonietta
AU - Maiorino, Maria Ida
AU - Bellastella, Giuseppe
AU - Signoriello, Giuseppe
AU - Knop, Filip K.
AU - Rizzo, Maria Rosaria
AU - Esposito, Katherine
N1 - Publisher Copyright: © 2023 The Author(s)
PY - 2023
Y1 - 2023
N2 - Aims: To evaluate cognitive function in subjects with type 2 diabetes (T2D) treated with glucagon-like peptide 1 receptor agonist (GLP-1RA) plus metformin or metformin alone and its association with endothelial progenitor cells (EPCs). Methods: Adults with T2D treated with GLP-1RA plus metformin (GLP-1RA + MET) or MET alone for at least 12 months were included. Montreal Cognitive Assessment test (MoCA), Mini-Mental State Examination (MMSE), Mini Nutritional Assessment (MNA) and disability tests were administered. Circulating levels of seven EPCs phenotypes were measured by flow cytometry. Results: A total of 154 elderly patients were included, of whom 78 in GLP-1RA + MET group and 76 in MET group. The GLP-1RA + MET group showed better cognitive function as indicated by a significant higher MoCA and MMSE scores, and higher levels of CD34+ CD133+, CD133+ KDR+, and CD34+ CD133+ KDR+ as compared with MET group. The number of CD34+ CD133+ KDR+ cells was an independent predictor of higher MoCA, MMSE and MNA scores. Conclusions: People with T2D on GLP-1RA + MET treatment had better cognitive function and higher circulating levels of EPCs as compared with those on MET alone warranting further studies to understand the interrelationship between EPCs, GLP-RA treatment and cognitive health.
AB - Aims: To evaluate cognitive function in subjects with type 2 diabetes (T2D) treated with glucagon-like peptide 1 receptor agonist (GLP-1RA) plus metformin or metformin alone and its association with endothelial progenitor cells (EPCs). Methods: Adults with T2D treated with GLP-1RA plus metformin (GLP-1RA + MET) or MET alone for at least 12 months were included. Montreal Cognitive Assessment test (MoCA), Mini-Mental State Examination (MMSE), Mini Nutritional Assessment (MNA) and disability tests were administered. Circulating levels of seven EPCs phenotypes were measured by flow cytometry. Results: A total of 154 elderly patients were included, of whom 78 in GLP-1RA + MET group and 76 in MET group. The GLP-1RA + MET group showed better cognitive function as indicated by a significant higher MoCA and MMSE scores, and higher levels of CD34+ CD133+, CD133+ KDR+, and CD34+ CD133+ KDR+ as compared with MET group. The number of CD34+ CD133+ KDR+ cells was an independent predictor of higher MoCA, MMSE and MNA scores. Conclusions: People with T2D on GLP-1RA + MET treatment had better cognitive function and higher circulating levels of EPCs as compared with those on MET alone warranting further studies to understand the interrelationship between EPCs, GLP-RA treatment and cognitive health.
KW - Cognitive function
KW - Elderly patients
KW - Endothelial progenitor cells
KW - EPCs
KW - GLP-1RA
KW - Glucagon-like peptide 1 receptor agonists
KW - Metformin
KW - Type 2 diabetes
U2 - 10.1016/j.diabres.2023.110688
DO - 10.1016/j.diabres.2023.110688
M3 - Journal article
C2 - 37116797
AN - SCOPUS:85156193647
VL - 200
JO - Diabetes Research and Clinical Practice. Supplement
JF - Diabetes Research and Clinical Practice. Supplement
SN - 1572-1671
M1 - 110688
ER -
ID: 365665991