Extracellular Vesicle Therapy for Type 1 Diabetes
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Extracellular Vesicle Therapy for Type 1 Diabetes. / Soltani, Setareh; Mansouri, Kamran; Emami Aleagha, Mohammad Sajad; Moasefi, Narges; Yavari, Niloofar; Shakouri, Seyed Kazem; Notararigo, Sara; Shojaeian, Ali; Pociot, Flemming; Yarani, Reza.
In: Frontiers in Immunology, Vol. 13, 865782, 2022.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Extracellular Vesicle Therapy for Type 1 Diabetes
AU - Soltani, Setareh
AU - Mansouri, Kamran
AU - Emami Aleagha, Mohammad Sajad
AU - Moasefi, Narges
AU - Yavari, Niloofar
AU - Shakouri, Seyed Kazem
AU - Notararigo, Sara
AU - Shojaeian, Ali
AU - Pociot, Flemming
AU - Yarani, Reza
N1 - Publisher Copyright: Copyright © 2022 Soltani, Mansouri, Emami Aleagha, Moasefi, Yavari, Shakouri, Notararigo, Shojaeian, Pociot and Yarani.
PY - 2022
Y1 - 2022
N2 - Type 1 diabetes (T1D) is a chronic disorder characterized by immune-mediated destruction of pancreatic insulin-producing β-cells. The primary treatment for T1D is multiple daily insulin injections to control blood sugar levels. Cell-free delivery packets with therapeutic properties, extracellular vesicles (EVs), mainly from stem cells, have recently gained considerable attention for disease treatments. EVs provide a great potential to treat T1D ascribed to their regenerative, anti-inflammatory, and immunomodulatory effects. Here, we summarize the latest EV applications for T1D treatment and highlight opportunities for further investigation.
AB - Type 1 diabetes (T1D) is a chronic disorder characterized by immune-mediated destruction of pancreatic insulin-producing β-cells. The primary treatment for T1D is multiple daily insulin injections to control blood sugar levels. Cell-free delivery packets with therapeutic properties, extracellular vesicles (EVs), mainly from stem cells, have recently gained considerable attention for disease treatments. EVs provide a great potential to treat T1D ascribed to their regenerative, anti-inflammatory, and immunomodulatory effects. Here, we summarize the latest EV applications for T1D treatment and highlight opportunities for further investigation.
KW - exosomes
KW - extracellular vesicle
KW - immunomodulation
KW - therapy
KW - type 1 diabetes
KW - β-cell
U2 - 10.3389/fimmu.2022.865782
DO - 10.3389/fimmu.2022.865782
M3 - Review
C2 - 35464488
AN - SCOPUS:85128616254
VL - 13
JO - Frontiers in Immunology
JF - Frontiers in Immunology
SN - 1664-3224
M1 - 865782
ER -
ID: 305713545