In vivo molecular imaging of cardiac angiogenesis in persons with and without type 2 diabetes: A cross-sectional 68Ga-RGD-PET study

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In vivo molecular imaging of cardiac angiogenesis in persons with and without type 2 diabetes : A cross-sectional 68Ga-RGD-PET study. / Laursen, Jens Christian; Rasmussen, Ida Kirstine Bull; Zobel, Emilie Hein; Hasbak, Philip; Holmvang, Lene; Hansen, Christian Stevns; von Scholten, Bernt Johan; Frimodt-Moller, Marie; Rossing, Peter; Hansen, Tine Willum; Kjaer, Andreas; Ripa, Rasmus Sejersten.

In: Diabetic Medicine, Vol. 40, No. 1, 2023, p. e14960.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Laursen, JC, Rasmussen, IKB, Zobel, EH, Hasbak, P, Holmvang, L, Hansen, CS, von Scholten, BJ, Frimodt-Moller, M, Rossing, P, Hansen, TW, Kjaer, A & Ripa, RS 2023, 'In vivo molecular imaging of cardiac angiogenesis in persons with and without type 2 diabetes: A cross-sectional 68Ga-RGD-PET study', Diabetic Medicine, vol. 40, no. 1, pp. e14960. https://doi.org/10.1111/dme.14960

APA

Laursen, J. C., Rasmussen, I. K. B., Zobel, E. H., Hasbak, P., Holmvang, L., Hansen, C. S., von Scholten, B. J., Frimodt-Moller, M., Rossing, P., Hansen, T. W., Kjaer, A., & Ripa, R. S. (2023). In vivo molecular imaging of cardiac angiogenesis in persons with and without type 2 diabetes: A cross-sectional 68Ga-RGD-PET study. Diabetic Medicine, 40(1), e14960. https://doi.org/10.1111/dme.14960

Vancouver

Laursen JC, Rasmussen IKB, Zobel EH, Hasbak P, Holmvang L, Hansen CS et al. In vivo molecular imaging of cardiac angiogenesis in persons with and without type 2 diabetes: A cross-sectional 68Ga-RGD-PET study. Diabetic Medicine. 2023;40(1):e14960. https://doi.org/10.1111/dme.14960

Author

Laursen, Jens Christian ; Rasmussen, Ida Kirstine Bull ; Zobel, Emilie Hein ; Hasbak, Philip ; Holmvang, Lene ; Hansen, Christian Stevns ; von Scholten, Bernt Johan ; Frimodt-Moller, Marie ; Rossing, Peter ; Hansen, Tine Willum ; Kjaer, Andreas ; Ripa, Rasmus Sejersten. / In vivo molecular imaging of cardiac angiogenesis in persons with and without type 2 diabetes : A cross-sectional 68Ga-RGD-PET study. In: Diabetic Medicine. 2023 ; Vol. 40, No. 1. pp. e14960.

Bibtex

@article{62603497607540ee9f71386b65f1e27d,
title = "In vivo molecular imaging of cardiac angiogenesis in persons with and without type 2 diabetes: A cross-sectional 68Ga-RGD-PET study",
abstract = "Aims To assess cardiac angiogenesis in type 2 diabetes by positron emission tomography (PET) tracer [Ga-68]Ga-NODAGA-E[(cRGDyK)](2) (Ga-68-RGD) imaging. Methods Cross-sectional study including 20 persons with type 2 diabetes and 10 non-diabetic controls (CONs). Primary prespecified outcome was difference in cardiac angiogenesis (cardiac Ga-68-RGD mean target-to-background ratio [TBRmean]) between type 2 diabetes and CONs. Secondary outcome was to investigate associations between cardiac angiogenesis and kidney function and other risk factors. Results Participants with type 2 diabetes had a mean +/- SD age of 61 +/- 9 years, 30% were women, median (IQR) diabetes duration of 11 (6-19) years and 3 (15%) had a history of cardiovascular disease. The CONs had comparable age and sex distribution to the participants with type 2 diabetes, and none had a history of coronary artery disease. Myocardial flow reserve was lower in type 2 diabetes (2.7 +/- 0.6) compared with CONs (3.4 +/- 1.2) ( p = 0.03) and coronary artery calcium score was higher (562 [142-905] vs. 1 [0-150] p = 0.04). Cardiac Ga-68-RGD TBRmean was similar in participants with type 2 diabetes (0.89 +/- 0.09) and CONs (0.89 +/- 0.10) ( p = 0.92). Cardiac Ga-68-RGD TBRmean was not associated with estimated glomerular filtration rate, urine albumin creatinine ratio, cardiovascular disease, coronary artery calcium score or baroreflex sensitivity, neither in pooled analyses nor in type 2 diabetes. Conclusions Cardiac angiogenesis, evaluated with Ga-68-RGD PET, was similar in type 2 diabetes and CONs. Cardiac angiogenesis was not associated with kidney function or other risk markers in pooled analyses or in analyses restricted to type 2 diabetes.",
keywords = "atherosclerosis, autonomic neuropathy, imaging, kidney disease, Type 2 diabetes, POSITRON-EMISSION-TOMOGRAPHY, INTEGRIN, QUANTIFICATION, EXPRESSION, DIAGNOSIS, MELLITUS, DISEASE, IMPACT",
author = "Laursen, {Jens Christian} and Rasmussen, {Ida Kirstine Bull} and Zobel, {Emilie Hein} and Philip Hasbak and Lene Holmvang and Hansen, {Christian Stevns} and {von Scholten}, {Bernt Johan} and Marie Frimodt-Moller and Peter Rossing and Hansen, {Tine Willum} and Andreas Kjaer and Ripa, {Rasmus Sejersten}",
year = "2023",
doi = "10.1111/dme.14960",
language = "English",
volume = "40",
pages = "e14960",
journal = "Diabetic Medicine",
issn = "0742-3071",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - In vivo molecular imaging of cardiac angiogenesis in persons with and without type 2 diabetes

T2 - A cross-sectional 68Ga-RGD-PET study

AU - Laursen, Jens Christian

AU - Rasmussen, Ida Kirstine Bull

AU - Zobel, Emilie Hein

AU - Hasbak, Philip

AU - Holmvang, Lene

AU - Hansen, Christian Stevns

AU - von Scholten, Bernt Johan

AU - Frimodt-Moller, Marie

AU - Rossing, Peter

AU - Hansen, Tine Willum

AU - Kjaer, Andreas

AU - Ripa, Rasmus Sejersten

PY - 2023

Y1 - 2023

N2 - Aims To assess cardiac angiogenesis in type 2 diabetes by positron emission tomography (PET) tracer [Ga-68]Ga-NODAGA-E[(cRGDyK)](2) (Ga-68-RGD) imaging. Methods Cross-sectional study including 20 persons with type 2 diabetes and 10 non-diabetic controls (CONs). Primary prespecified outcome was difference in cardiac angiogenesis (cardiac Ga-68-RGD mean target-to-background ratio [TBRmean]) between type 2 diabetes and CONs. Secondary outcome was to investigate associations between cardiac angiogenesis and kidney function and other risk factors. Results Participants with type 2 diabetes had a mean +/- SD age of 61 +/- 9 years, 30% were women, median (IQR) diabetes duration of 11 (6-19) years and 3 (15%) had a history of cardiovascular disease. The CONs had comparable age and sex distribution to the participants with type 2 diabetes, and none had a history of coronary artery disease. Myocardial flow reserve was lower in type 2 diabetes (2.7 +/- 0.6) compared with CONs (3.4 +/- 1.2) ( p = 0.03) and coronary artery calcium score was higher (562 [142-905] vs. 1 [0-150] p = 0.04). Cardiac Ga-68-RGD TBRmean was similar in participants with type 2 diabetes (0.89 +/- 0.09) and CONs (0.89 +/- 0.10) ( p = 0.92). Cardiac Ga-68-RGD TBRmean was not associated with estimated glomerular filtration rate, urine albumin creatinine ratio, cardiovascular disease, coronary artery calcium score or baroreflex sensitivity, neither in pooled analyses nor in type 2 diabetes. Conclusions Cardiac angiogenesis, evaluated with Ga-68-RGD PET, was similar in type 2 diabetes and CONs. Cardiac angiogenesis was not associated with kidney function or other risk markers in pooled analyses or in analyses restricted to type 2 diabetes.

AB - Aims To assess cardiac angiogenesis in type 2 diabetes by positron emission tomography (PET) tracer [Ga-68]Ga-NODAGA-E[(cRGDyK)](2) (Ga-68-RGD) imaging. Methods Cross-sectional study including 20 persons with type 2 diabetes and 10 non-diabetic controls (CONs). Primary prespecified outcome was difference in cardiac angiogenesis (cardiac Ga-68-RGD mean target-to-background ratio [TBRmean]) between type 2 diabetes and CONs. Secondary outcome was to investigate associations between cardiac angiogenesis and kidney function and other risk factors. Results Participants with type 2 diabetes had a mean +/- SD age of 61 +/- 9 years, 30% were women, median (IQR) diabetes duration of 11 (6-19) years and 3 (15%) had a history of cardiovascular disease. The CONs had comparable age and sex distribution to the participants with type 2 diabetes, and none had a history of coronary artery disease. Myocardial flow reserve was lower in type 2 diabetes (2.7 +/- 0.6) compared with CONs (3.4 +/- 1.2) ( p = 0.03) and coronary artery calcium score was higher (562 [142-905] vs. 1 [0-150] p = 0.04). Cardiac Ga-68-RGD TBRmean was similar in participants with type 2 diabetes (0.89 +/- 0.09) and CONs (0.89 +/- 0.10) ( p = 0.92). Cardiac Ga-68-RGD TBRmean was not associated with estimated glomerular filtration rate, urine albumin creatinine ratio, cardiovascular disease, coronary artery calcium score or baroreflex sensitivity, neither in pooled analyses nor in type 2 diabetes. Conclusions Cardiac angiogenesis, evaluated with Ga-68-RGD PET, was similar in type 2 diabetes and CONs. Cardiac angiogenesis was not associated with kidney function or other risk markers in pooled analyses or in analyses restricted to type 2 diabetes.

KW - atherosclerosis

KW - autonomic neuropathy

KW - imaging

KW - kidney disease

KW - Type 2 diabetes

KW - POSITRON-EMISSION-TOMOGRAPHY

KW - INTEGRIN

KW - QUANTIFICATION

KW - EXPRESSION

KW - DIAGNOSIS

KW - MELLITUS

KW - DISEASE

KW - IMPACT

U2 - 10.1111/dme.14960

DO - 10.1111/dme.14960

M3 - Journal article

C2 - 36135822

VL - 40

SP - e14960

JO - Diabetic Medicine

JF - Diabetic Medicine

SN - 0742-3071

IS - 1

ER -

ID: 323205957