Increased Hepatic Insulin Clearance After Roux-en-Y Gastric Bypass

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Increased Hepatic Insulin Clearance After Roux-en-Y Gastric Bypass. / Bojsen-Møller, Kirstine N; Dirksen, Carsten; Jørgensen, Nils B; Jacobsen, Siv H; Hansen, Dorte L; Worm, Dorte; Naver, Lars; Kristiansen, Viggo B; Holst, Jens Juul; Madsbad, Sten.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 98, No. 6, 22.04.2013, p. E1066-E1071.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bojsen-Møller, KN, Dirksen, C, Jørgensen, NB, Jacobsen, SH, Hansen, DL, Worm, D, Naver, L, Kristiansen, VB, Holst, JJ & Madsbad, S 2013, 'Increased Hepatic Insulin Clearance After Roux-en-Y Gastric Bypass', Journal of Clinical Endocrinology and Metabolism, vol. 98, no. 6, pp. E1066-E1071. https://doi.org/10.1210/jc.2013-1286

APA

Bojsen-Møller, K. N., Dirksen, C., Jørgensen, N. B., Jacobsen, S. H., Hansen, D. L., Worm, D., Naver, L., Kristiansen, V. B., Holst, J. J., & Madsbad, S. (2013). Increased Hepatic Insulin Clearance After Roux-en-Y Gastric Bypass. Journal of Clinical Endocrinology and Metabolism, 98(6), E1066-E1071. https://doi.org/10.1210/jc.2013-1286

Vancouver

Bojsen-Møller KN, Dirksen C, Jørgensen NB, Jacobsen SH, Hansen DL, Worm D et al. Increased Hepatic Insulin Clearance After Roux-en-Y Gastric Bypass. Journal of Clinical Endocrinology and Metabolism. 2013 Apr 22;98(6):E1066-E1071. https://doi.org/10.1210/jc.2013-1286

Author

Bojsen-Møller, Kirstine N ; Dirksen, Carsten ; Jørgensen, Nils B ; Jacobsen, Siv H ; Hansen, Dorte L ; Worm, Dorte ; Naver, Lars ; Kristiansen, Viggo B ; Holst, Jens Juul ; Madsbad, Sten. / Increased Hepatic Insulin Clearance After Roux-en-Y Gastric Bypass. In: Journal of Clinical Endocrinology and Metabolism. 2013 ; Vol. 98, No. 6. pp. E1066-E1071.

Bibtex

@article{f05140dc6fe147c58997ae541b5452bd,
title = "Increased Hepatic Insulin Clearance After Roux-en-Y Gastric Bypass",
abstract = "Context:Roux-en-Y gastric bypass (RYGB) improves glucose tolerance and ameliorates fasting hyperinsulinemia within days after surgery. Improvements in hepatic insulin sensitivity and insulin clearance could contribute importantly to these effects.Objective:The objective of the investigation was to study changes in insulin clearance after RYGB.Design:This was a prospective study of fasting hepatic insulin clearance and, in a subgroup of patients, postprandial insulin clearance after a meal test before and 1 week, 3 months, and 1 year after RYGB.Setting:The study was conducted at Hvidovre Hospital (Hvidovre, Denmark).Patients:Patients included 2 groups of obese RYGB-patients: 1) type 2 diabetes (T2D) group: 32 patients with T2D (meal test, n = 13), 2) normal glucose tolerance (NGT) group: 32 patients with NGT (meal test, n = 12).Intervention:The intervention was RYGB.Main Outcome Measure:Fasting hepatic insulin clearance (fasting C-peptide/fasting insulin). Postprandial insulin clearance (incremental areas under the curve of insulin secretion rates/incremental areas under the curve of insulin).Results:Fasting hepatic insulin clearance increased after 1 week (P <.01) and further at 3 months (P <.01), remaining elevated 1 year postoperatively (P <.01) with no difference between the T2D and NGT groups. Postprandial insulin clearance changed only in the T2D group with an increase at 1 week (P <.01) that was maintained at 3 months (P = .06) and 1 year (P <.01).Conclusions:RYGB increases insulin clearance within 1 week after surgery, highlighting the liver as a key organ involved in the early beneficial effect on glucose metabolism. Postprandial insulin secretion may be underestimated postoperatively in patients with type 2 diabetes when evaluated by peripheral insulin concentrations instead of insulin secretion rates or C-peptide.",
author = "Bojsen-M{\o}ller, {Kirstine N} and Carsten Dirksen and J{\o}rgensen, {Nils B} and Jacobsen, {Siv H} and Hansen, {Dorte L} and Dorte Worm and Lars Naver and Kristiansen, {Viggo B} and Holst, {Jens Juul} and Sten Madsbad",
year = "2013",
month = apr,
day = "22",
doi = "10.1210/jc.2013-1286",
language = "English",
volume = "98",
pages = "E1066--E1071",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "Oxford University Press",
number = "6",

}

RIS

TY - JOUR

T1 - Increased Hepatic Insulin Clearance After Roux-en-Y Gastric Bypass

AU - Bojsen-Møller, Kirstine N

AU - Dirksen, Carsten

AU - Jørgensen, Nils B

AU - Jacobsen, Siv H

AU - Hansen, Dorte L

AU - Worm, Dorte

AU - Naver, Lars

AU - Kristiansen, Viggo B

AU - Holst, Jens Juul

AU - Madsbad, Sten

PY - 2013/4/22

Y1 - 2013/4/22

N2 - Context:Roux-en-Y gastric bypass (RYGB) improves glucose tolerance and ameliorates fasting hyperinsulinemia within days after surgery. Improvements in hepatic insulin sensitivity and insulin clearance could contribute importantly to these effects.Objective:The objective of the investigation was to study changes in insulin clearance after RYGB.Design:This was a prospective study of fasting hepatic insulin clearance and, in a subgroup of patients, postprandial insulin clearance after a meal test before and 1 week, 3 months, and 1 year after RYGB.Setting:The study was conducted at Hvidovre Hospital (Hvidovre, Denmark).Patients:Patients included 2 groups of obese RYGB-patients: 1) type 2 diabetes (T2D) group: 32 patients with T2D (meal test, n = 13), 2) normal glucose tolerance (NGT) group: 32 patients with NGT (meal test, n = 12).Intervention:The intervention was RYGB.Main Outcome Measure:Fasting hepatic insulin clearance (fasting C-peptide/fasting insulin). Postprandial insulin clearance (incremental areas under the curve of insulin secretion rates/incremental areas under the curve of insulin).Results:Fasting hepatic insulin clearance increased after 1 week (P <.01) and further at 3 months (P <.01), remaining elevated 1 year postoperatively (P <.01) with no difference between the T2D and NGT groups. Postprandial insulin clearance changed only in the T2D group with an increase at 1 week (P <.01) that was maintained at 3 months (P = .06) and 1 year (P <.01).Conclusions:RYGB increases insulin clearance within 1 week after surgery, highlighting the liver as a key organ involved in the early beneficial effect on glucose metabolism. Postprandial insulin secretion may be underestimated postoperatively in patients with type 2 diabetes when evaluated by peripheral insulin concentrations instead of insulin secretion rates or C-peptide.

AB - Context:Roux-en-Y gastric bypass (RYGB) improves glucose tolerance and ameliorates fasting hyperinsulinemia within days after surgery. Improvements in hepatic insulin sensitivity and insulin clearance could contribute importantly to these effects.Objective:The objective of the investigation was to study changes in insulin clearance after RYGB.Design:This was a prospective study of fasting hepatic insulin clearance and, in a subgroup of patients, postprandial insulin clearance after a meal test before and 1 week, 3 months, and 1 year after RYGB.Setting:The study was conducted at Hvidovre Hospital (Hvidovre, Denmark).Patients:Patients included 2 groups of obese RYGB-patients: 1) type 2 diabetes (T2D) group: 32 patients with T2D (meal test, n = 13), 2) normal glucose tolerance (NGT) group: 32 patients with NGT (meal test, n = 12).Intervention:The intervention was RYGB.Main Outcome Measure:Fasting hepatic insulin clearance (fasting C-peptide/fasting insulin). Postprandial insulin clearance (incremental areas under the curve of insulin secretion rates/incremental areas under the curve of insulin).Results:Fasting hepatic insulin clearance increased after 1 week (P <.01) and further at 3 months (P <.01), remaining elevated 1 year postoperatively (P <.01) with no difference between the T2D and NGT groups. Postprandial insulin clearance changed only in the T2D group with an increase at 1 week (P <.01) that was maintained at 3 months (P = .06) and 1 year (P <.01).Conclusions:RYGB increases insulin clearance within 1 week after surgery, highlighting the liver as a key organ involved in the early beneficial effect on glucose metabolism. Postprandial insulin secretion may be underestimated postoperatively in patients with type 2 diabetes when evaluated by peripheral insulin concentrations instead of insulin secretion rates or C-peptide.

U2 - 10.1210/jc.2013-1286

DO - 10.1210/jc.2013-1286

M3 - Journal article

C2 - 23609835

VL - 98

SP - E1066-E1071

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 6

ER -

ID: 45839975