Jakob Benedict Seidelin

Jakob Benedict Seidelin

Clinical Professor

Member of:

  • Internal Medicine: Gastroenterology and Hepatology

ORCID: 0000-0003-3230-7966

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  1. Published

    Expression profiling of apoptosis-related genes in enterocytes isolated from patients with ulcerative colitis

    Seidelin, Jakob Benedict & Nielsen, Ole Haagen, 2013, In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 114, 7-8, p. 508-17 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Fluorescence-based tracing of transplanted intestinal epithelial cells using confocal laser endomicroscopy

    Bergenheim, F., Seidelin, Jakob Benedict, Pedersen, M. T., Mead, B. E., Jensen, Kim Bak, Karp, J. M. & Nielsen, Ole Haagen, 2019, In: Stem Cell Research & Therapy. 10, 1, p. 1-12 12 p., 148.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    GM6001 Increases Anastomotic Leakage following Colonic Obstruction Possibly by Impeding Epithelialization

    Rehn, M., Krarup, P., Christensen, L. H., Seidelin, Jakob Benedict, Ågren, Magnus & Syk, I., Nov 2015, In: Surgical Infections. 16, 6, p. 702-8 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    IAPs and RIPK1 mediate LPS-induced cytokine production in healthy subjects and Crohn's disease

    Seidelin, Jakob Benedict, Jensen, Simone, Hansen, M., Bronze, M. R. D. C., Cuchet-Lourenҫo, D., Nejentsev, S., LaCasse, E. C. & Nielsen, Ole Haagen, 2024, In: Clinical and Experimental Immunology. 215, 3, p. 291–301 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    IBD metabonomics predicts phenotype, disease course, and treatment response

    Bjerrum, Jakob Tveiten , Wang, Y. L., Seidelin, Jakob Benedict & Nielsen, Ole Haagen, 2021, In: EBioMedicine. 71, 103551.

    Research output: Contribution to journal › Review › Research › peer-review

  6. Published

    IL-33 is upregulated in colonocytes of ulcerative colitis

    Seidelin, Jakob Benedict, Bjerrum, Jakob Tveiten , Coskun, M., Widjaya, B., Vainer, B., Nielsen, Ole Haagen, Seidelin, J. B., Bjerrum, J. T., Coskun, M., Widjaya, B., Vainer, B. & Nielsen, Ole Haagen, 2010, In: Immunology Letters. 128, 1, p. 80-5 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    IL-33 promotes GATA-3 polarization of gut-derived T cells in experimental and ulcerative colitis

    Seidelin, Jakob Benedict, Coskun, M., Kvist, P. H., Holm, T. L., Holgersen, Kristine & Nielsen, Ole Haagen, Feb 2015, In: Journal of Gastroenterology. 50, 2, p. 180-190 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Identification of TNF-α-responsive promoters and enhancers in the intestinal epithelial cell model Caco-2

    Boyd, M., Coskun, M., Lilje, B., Andersson, Robin, Hoof, I., Lange, Jette Bornholdt, Dahlgaard, K., Olsen, Jørgen, Vitezic, M., Bjerrum, Jakob Tveiten , Seidelin, Jakob Benedict, Nielsen, Ole Haagen, Troelsen, J. & Sandelin, Albin Gustav, 2014, In: D N A Research. 21, 6, p. 569-583 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Impact of T300A Variant of ATG16L1 on Antibacterial Response, Risk of Culture Positive Infections, and Clinical Course of Crohn's Disease

    Salem, M., Nielsen, Ole Haagen, Nys, K., Yazdanyar, S. & Seidelin, Jakob Benedict, Nov 2015, In: Clinical and Translational Gastroenterology. 6, 9 p., e122.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Accepted/In press

    Infant Ustekinumab Clearance, Risk of Infection, and Development After Exposure During Pregnancy

    Julsgaard, M., Wieringa, J. W., Baunwall, S. M. D., Bibby, B. M., Driessen, G. J. A., Kievit, L., Brodersen, J. B., Poulsen, A., Kjeldsen, J., Hansen, M. M., Tang, H. Q., Balmer, C. L., Glerup, H., Seidelin, J. B., Haderslev, K. V., Svenningsen, L., Wildt, S., Juel, M. A., Neumann, A., Fuglsang, J. & 31 others, Jess, T., Haase, A. M., Hvas, C. L., Kelsen, J., Janneke van der Woude, C., Korgaard, J., Vestergaard, T., Lystbæk, U. L., Berg, A., Mikkelsen, A. T., Holm, A. M., Hansen, A. B., Mathiesen, O., Jensen, J. K., Neumann, L., Boris, J., Lemming, M., Rahbek, M., Westergaard, H. B., Friis-Hansen, L. J., Møller, L. A., Søeby, K., Hilsted, L., Christiansen, L., Sharif, H., Langholz, Ebbe, Kamstrup, P. R., Jochumsen, A., Huusom, Lene Drasbek, Wilken-Jensen, C. & NEXUS Collaborator Group, N. C. G., 2024, (Accepted/In press) In: Clinical Gastroenterology and Hepatology. 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Inflammatory Bowel Diseases Affect the Phenotype and Disease Course of Coexisting Immune-Mediated Inflammatory Diseases: A Systematic Review With Meta-Analysis

    Attauabi, M., Wewer, M. D., Bendtsen, Flemming, Seidelin, Jakob Benedict & Burisch, J., 2022, In: Inflammatory Bowel Diseases. 28, 11, p. 1756–1765

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Influence of Genetics, Immunity and the Microbiome on the Prognosis of Inflammatory Bowel Disease (IBD Prognosis Study): the protocol for a Copenhagen IBD Inception Cohort Study

    Attauabi, M., Madsen, G. R., Bendtsen, F., Wewer, A. V., Wilkens, R., Ilvemark, J., Vladimirova, N., Jensen, A. B., Jensen, F. K., Hansen, S. B., Siebner, H. R., Nielsen, Y. J. W., Møller, J. M., Thomsen, H. S., Thomsen, S. F., Ingels, H. A. S., Theede, K., Boysen, T., Bjerrum, J. T., Jakobsen, C. & 13 others, Dorn-Rasmussen, M., Jansson, S., Yao, Y., Burian, E. A., Møller, F. T., Fana, V., Wiell, C., Terslev, Lene, Østergaard, Mikkel, Bertl, K., Stavropoulos, A., Seidelin, Jakob Benedict & Burisch, J., 2022, In: BMJ Open. 12, 6, e055779.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Inhibitors of apoptosis (IAPs) regulate intestinal immunity and inflammatory bowel disease (IBD) inflammation

    Pedersen, J., LaCasse, E. C., Seidelin, Jakob Benedict, Coskun, M. & Nielsen, Ole Haagen, Nov 2014, In: Trends in Molecular Medicine. 20, 11, p. 652-65 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Insulin-like growth factor binding protein 3 in inflammatory bowel disease

    Kirman, I., Whelan, R. L., Jain, S., Nielsen, S. E., Seidelin, Jakob Benedict & Nielsen, Ole Haagen, Apr 2005, In: Digestive Diseases and Sciences. 50, 4, p. 780-4 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Intestinal ultrasound in inflammatory bowel disease

    Bjerrum, Jakob Tveiten , Ilvemark, J., Seidelin, Jakob Benedict & Wilkens, R., 5 Feb 2024, In: Ugeskrift for Laeger. 186, 6

    Research output: Contribution to journal › Review › Research › peer-review

  16. Published

    Letter: be careful of gastrointestinal CMV infection in adverse event from ICIs therapy in solid tumours — Authors' reply

    Dahl, E., Abed, O., Agnholt, J., Bjerrum, Jakob Tveiten , Dige, A., Kjeldsen, J., Svane, Inge Marie, Donia, M. & Seidelin, Jakob Benedict, 2023, In: Alimentary Pharmacology and Therapeutics. 57, 8, p. 918-919

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  17. Published

    Lipidomic Trajectories Characterize Delayed Mucosal Wound Healing in Quiescent Ulcerative Colitis and Identify Potential Novel Therapeutic Targets

    Bjerrum, Jakob Tveiten , Wang, Y., Zhang, J., Riis, Lene Buhl, Nielsen, Ole Haagen & Seidelin, Jakob Benedict, 2022, In: International Journal of Biological Sciences. 18, 5, p. 1813-1828 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    MAP kinases in inflammatory bowel disease

    Coskun, M., Olsen, Jørgen, Seidelin, Jakob Benedict & Nielsen, Ole Haagen, 2011, In: Clinica Chimica Acta. 412, 7-8, p. 513-20 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    MicroRNAs in inflammatory bowel disease--pathogenesis, diagnostics and therapeutics

    Coskun, M., Bjerrum, J. T., Seidelin, Jakob Benedict & Nielsen, Ole Haagen, 2012, In: World Journal of Gastroenterology. 18, 34, p. 4629-34 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Mucosal healing in ulcerative colitis: pathophysiology and pharmacology

    Seidelin, Jakob Benedict, Coskun, M. & Nielsen, Ole Haagen, 2013, In: Advances in Clinical Chemistry. 59, p. 101-23 23 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Muramyl dipeptide responsive pathways in Crohn's disease: from NOD2 and beyond

    Salem, M., Seidelin, Jakob Benedict, Rogler, G. & Nielsen, Ole Haagen, 2013, In: Cellular and Molecular Life Sciences. 70, p. 3391-3404

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Noninfectious & noninflammatory bowel disease colitis

    Nielsen, Ole Haagen, Bjerrum, Jakob Tveiten & Seidelin, Jakob Benedict, 1 Mar 2013, Advances in the Management of Inflammatory Bowel Disease. Future Medicine Ltd., p. 33-49 17 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  23. Published

    Objective Quantification of Immune Cell Infiltrates and Epidermal Proliferation in Psoriatic Skin: A Comparison of Digital Image Analysis and Manual Counting

    Soendergaard, C., Nielsen, Ole Haagen, Skak, K., Røpke, M. A., Seidelin, Jakob Benedict & Kvist, P. H., 2015, In: Applied Immunohistochemistry & Molecular Morphology. p. 1-6 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Optimizing Screening for Colorectal Cancer: An Algorithm Combining Fecal Immunochemical Test, Blood-Based Cancer-Associated Proteins and Demographics to Reduce Colonoscopy Burden

    Petersen, M. M., Kleif, Jakob, Jørgensen, Lars Nannestad, Hendel, J. W., Seidelin, Jakob Benedict, Madsen, M. R., Vilandt, J., Brandsborg, S., Rasmussen, J. S., Andersen, L. M., Khalid, A., Ferm, L., Gawel, S. H., Martens, F., Andersen, B., Rasmussen, Morten, Davis, G. J., Christensen, I. J. & Therkildsen, C., 2023, In: Clinical Colorectal Cancer. 22, 2, p. 199-210 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Outcome after discontinuation of infliximab in patients with inflammatory bowel disease in clinical remission: an observational Danish single center study

    Steenholdt, C., Molazahi, A., Ainsworth, M. A., Brynskov, J., Thomsen, O. Ø. & Seidelin, Jakob Benedict, 2012, In: Scandinavian Journal of Gastroenterology.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Outcomes and long-term effects of COVID-19 in patients with inflammatory bowel diseases - a Danish prospective population-based cohort study with individual-level data

    Attauabi, M., Dahlerup, J. F., Poulsen, A., Hansen, M. R., Verner-Andersen, M. K., Eraslan, S., Prahm, A. P., Pedersen, N., Larsen, L., Jess, T., Neumann, A., Haderslev, K. V., Molazahi, A., Lødrup, A. B., Glerup, H., Oppfeldt, A. M., Jensen, M. D., Theede, K., Kiszka-Kanowitz, M., Seidelin, J. B. & 1 others, Burisch, J., 2022, In: Journal of Crohn's and Colitis. 16, 5, p. 757–767 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Pathogenesis and biomarkers of carcinogenesis in ulcerative colitis

    Thorsteinsdottir, S., Gudjónsson, Thorkell, Nielsen, Ole Haagen, Vainer, B. & Seidelin, Jakob Benedict, 7 Jun 2011, In: Nature Reviews. Gastroenterology & Hepatology. 8, 7, p. 395-404 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. E-pub ahead of print

    Peripheral joint and enthesis involvement in patients with newly diagnosed inflammatory bowel disease: symptoms, clinical and ultrasound findings - a population-based cohort study

    Vladimirova, N., Terslev, Lene, Attauabi, M., Madsen, G., Fana, V., Wiell, C., Døhn, U. M., Bendtsen, Flemming, Seidelin, Jakob Benedict, Burisch, J. & Østergaard, Mikkel, 2024, (E-pub ahead of print) In: Journal of Crohn's & colitis.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Praktisk anvendelse af thiopuriner hos patienter med kronisk inflammatoriske tarmsygdomme

    Zhao, M., Wewer, M. D., Bjerrum, Jakob Tveiten , Steenholdt, Casper, Schiødt, Frank Vinholt, Haderslev, K., Kiszka-Kanowitz, M., Munkholm, Pia, Seidelin, Jakob Benedict & Burisch, J., 2022, In: Ugeskrift for Laeger. 184, 11, V09210706.

    Research output: Contribution to journal › Review › Research › peer-review

  30. E-pub ahead of print

    Predicting treatment response in ASUC: do we measure systemic severity, organ response or both?

    Ovesen, P. D., Ilvemark, J. F. K. F., Wilkens, R., Steenholdt, Casper & Seidelin, Jakob Benedict, 1 Apr 2024, (E-pub ahead of print) In: Gut. 2 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  31. Published

    Prediction of Relapse After Anti–Tumor Necrosis Factor Cessation in Crohn's Disease: Individual Participant Data Meta-analysis of 1317 Patients From 14 Studies

    Pauwels, R. W. M., van der Woude, C. J., Nieboer, D., Steyerberg, E. W., Casanova, M. J., Gisbert, J. P., Kennedy, N. A., Lees, C. W., Louis, E., Molnár, T., Szántó, K., Leo, E., Bots, S., Downey, R., Lukas, M., Lin, W. C., Amiot, A., Lu, C., Roblin, X., Farkas, K. & 15 others, Seidelin, Jakob Benedict, Duijvestein, M., D'Haens, G. R., de Vries, A. C., Janneke van der Woude, C., Sleutjes, J. A. M., García-Ortiz, J. M., Brooks, A. J., Hamlin, P. J., Sebastian, S., Lobo, A. J., Dieleman, L. (. A., Ben-Horin, S., Steenholdt, Casper & CEASE Study Group, C. S. G., 2022, In: Clinical Gastroenterology and Hepatology. 20, 8, p. 1671-1686.e16

    Research output: Contribution to journal › Review › Research › peer-review

  32. Published

    Predictors of response and disease course in patients with inflammatory bowel disease treated with biological therapy - The Danish IBD Biobank Project: protocol for a multicentre prospective cohort study

    Zhao, M., Bendtsen, Flemming, Petersen, Andreas Munk, Larsen, L., Dige, A., Hvas, C., Seidelin, Jakob Benedict & Burisch, J., 2020, In: BMJ Open. 10, 2, 7 p., e035756.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Prevalence and outcomes of COVID-19 among patients with inflammatory bowel disease: A Danish prospective population-based cohort study

    Attauabi, M., Poulsen, A., Theede, K., Pedersen, N., Larsen, L., Jess, T., Rosager Hansen, M., Kajbæk Verner-Andersen, M., V Haderslev, K., Berg Lødrup, A., Molazahi, A., Neumann, A., Wase, A., Seidelin, Jakob Benedict & Burisch, J., 2021, In: Journal of Crohn's and Colitis. 15, 4, p. 540–550

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Primary monocytes derived from ulcerative colitis show no difference in the TNF-alpha-induced immune response among responders and primary non-responders to infliximab

    Li, Y., Jensen, Kim Bak, Seidelin, Jakob Benedict & Nielsen, O. H., Sep 2017, In: Journal of Gastroenterology and Hepatology. 32, S3, p. 138-138 P-0750.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  35. Published

    Putative biomarkers of vedolizumab resistance and underlying inflammatory pathways involved in IBD

    Soendergaard, C., Seidelin, Jakob Benedict, Steenholdt, C. & Nielsen, Ole Haagen, 2018, In: B M J Open Gastroenterology. 5, 1, e000208.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Recent therapeutic advances in inflammatory bowel disease

    Nielsen, Ole Haagen, Nielsen, S. E. & Seidelin, Jakob Benedict, Jul 2002, In: I Drugs: the Investigational Drugs Journal. 5, 7, p. 618-22 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Regulation of antiapoptotic and cytoprotective pathways in colonic epithelial cells in ulcerative colitis

    Seidelin, Jakob Benedict, 2015, In: Scandinavian Journal of Gastroenterology. 50 , Suppl 1, p. 1-29 29 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Regulering af cytokindannelse ved inflammatoriske tarmsygdomme

    Ferrero-Miliani, L., Seidelin, Jakob Benedict & Nielsen, Ole Haagen, 8 May 2006, In: Ugeskrift for Laeger. 168, 19, p. 1847-50 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Relation between NOD2 genotype and changes in innate signaling in Crohn's disease on mRNA and miRNA levels

    Chen, Y., Salem, M., Boyd, M., Lange, Jette Bornholdt, Li, Yuan, Coskun, M., Seidelin, Jakob Benedict, Sandelin, Albin Gustav & Nielsen, Ole Haagen, 2017, In: npj Genomic Medicine. 2, 11 p., 3.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Reply to comment on: "Vedolizumab as the first line of biologic therapy for ulcerative colitis and Crohn's disease - a systematic review with meta-analysis"

    Attauabi, M., Seidelin, Jakob Benedict & Burisch, J., 2023, In: Rendiconti di Gastro-Enterologia. 55, 2, p. 300-301

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  41. Published

    SMAC mimetics and RIPK inhibitors as therapeutics for chronic inflammatory diseases

    Jensen, S., Seidelin, Jakob Benedict, LaCasse, E. C. & Nielsen, Ole Haagen, 2020, In: Science Signaling. 13, 619, 18 p., eaax8295.

    Research output: Contribution to journal › Review › Research › peer-review

  42. Published

    Safety and efficacy of infliximab and corticosteroid therapy in checkpoint inhibitor-induced colitis

    Dahl, E. K., Abed, O. K., Kjeldsen, J., dqp123, dqp123, Svane, Inge Marie, Dige, A., Agnholt, J. S., Bjerrum, Jakob Tveiten & Seidelin, Jakob Benedict, 2022, In: Alimentary Pharmacology and Therapeutics. 56, 9, p. 1370-1382 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Samtidig leptospirose og salmonellainfektion

    Rönsholt, F. F., Seidelin, Jakob Benedict & Villumsen, S., 4 May 2009, In: Ugeskrift for Laeger. 171, 19, p. 1607-9 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Seizure threshold to lidocaine is decreased following repeated ECS (electroconvulsive shock)

    Kragh, Jesper Vaczy, Seidelin, Jakob Benedict & Bolwig, T. G., 1993, In: Psychopharmacology. 111, 4, p. 495-8 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Short and long-term effectiveness and safety of vedolizumab in treatment-refractory patients with ulcerative colitis and Crohn's disease - a real-world two-center cohort study

    Attauabi, M., Vind, Ida, Pedersen, G., Bendtsen, Flemming, Seidelin, Jakob Benedict & Burisch, J., 2021, In: European journal of gastroenterology & hepatology. 33, 15, p. 709-718

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Simple and efficient method for isolation and cultivation of endoscopically obtained human colonocytes

    Seidelin, Jakob Benedict, Horn, T. & Nielsen, Ole Haagen, Dec 2003, In: A J P: Gastrointestinal and Liver Physiology (Online). 285, 6, p. G1122-8

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Soluble L-selectin levels predict survival in sepsis

    Seidelin, Jakob Benedict, Nielsen, Ole Haagen & Strøm, J., Nov 2002, In: Intensive Care Medicine. 28, 11, p. 1613-8 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Species-specific engagement of human nucleotide oligomerization domain 2 (NOD)2 and Toll-like receptor (TLR) signalling upon intracellular bacterial infection: role of Crohn's associated NOD2 gene variants

    Salem, M., Seidelin, Jakob Benedict, Eickhardt-Dalbøge, S. R., Alhede, M., Rogler, G. & Nielsen, Ole Haagen, Mar 2015, In: Clinical and Experimental Immunology. 179, 3, p. 426-34 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Systematic Review with Meta-analysis: The Impact of Cancer Treatments on the Disease Activity of Inflammatory Bowel Diseases

    Grimsdottir, S., Attauabi, M., Kristine Dahl, E., Burisch, J. & Seidelin, Jakob Benedict, 2023, In: Journal of Crohn's and Colitis. 17, 7, p. 1139-1153 15 p.

    Research output: Contribution to journal › Review › Research › peer-review

  50. Published

    Systemic and intestinal levels of factor XIII-A: the impact of inflammation on expression in macrophage subtypes

    Søndergaard, C., Kvist, P. H., Seidelin, Jakob Benedict, Pelzer, H. & Nielsen, Ole Haagen, Aug 2016, In: Journal of Gastroenterology. 51, 8, p. 796-807 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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