Circulating YKL-40 in patients with essential thrombocythemia and polycythemia vera treated with the novel histone deacetylase inhibitor vorinostat
Research output: Contribution to journal › Journal article › Research › peer-review
YKL-40 regulates vascular endothelial growth factors and induces tumor proliferation. We investigated YKL-40 before and after treatment with vorinostat in 31 polycythemia vera (PV) and 16 essential thrombocythemia (ET) patients. Baseline PV patient levels were 2 times higher than in healthy controls (P<0.0001) and 1.7 times higher than in ET (P=0.02). A significant correlation between YKL-40 at baseline and neutrophils, CRP, LDH, JAK2V617F and platelets in PV patients was observed, as well as a significantly greater reduction of YKL-40 levels in PV patients responding to therapy. YKL-40 might be a novel marker of disease burden and progression in myeloproliferative neoplasms.
Original language | English |
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Journal | Leukemia Research |
Volume | 38 |
Issue number | 7 |
Pages (from-to) | 816-821 |
Number of pages | 6 |
ISSN | 0145-2126 |
DOIs | |
Publication status | Published - Jul 2014 |
- Adipokines, Adult, Aged, Aged, 80 and over, C-Reactive Protein, Female, Histone Deacetylase Inhibitors, Humans, Hydroxamic Acids, Lectins, Male, Middle Aged, Polycythemia Vera, Thrombocythemia, Essential
Research areas
ID: 138381557