Risk of haematologic cancers among individuals tested for Borrelia burgdorferi antibodies, and Borrelia burgdorferi seropositive individuals: a nationwide population-based matched cohort study

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Risk of haematologic cancers among individuals tested for Borrelia burgdorferi antibodies, and Borrelia burgdorferi seropositive individuals : a nationwide population-based matched cohort study. / Tetens, Malte M.; Omland, Lars Haukali; Dessau, Ram; Ellermann-Eriksen, Svend; Andersen, Nanna S.; Jørgensen, Charlotte Sværke; Østergaard, Christian; Bodilsen, Jacob; Søgaard, Kirstine K.; Bangsborg, Jette; Nielsen, Alex Christian; Møller, Jens Kjølseth; Chen, Ming; Niemann, Carsten Utoft; Lebech, Anne Mette; Obel, Niels.

In: Clinical Microbiology and Infection, Vol. 30, No. 2, 2024, p. 231-239.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Tetens, MM, Omland, LH, Dessau, R, Ellermann-Eriksen, S, Andersen, NS, Jørgensen, CS, Østergaard, C, Bodilsen, J, Søgaard, KK, Bangsborg, J, Nielsen, AC, Møller, JK, Chen, M, Niemann, CU, Lebech, AM & Obel, N 2024, 'Risk of haematologic cancers among individuals tested for Borrelia burgdorferi antibodies, and Borrelia burgdorferi seropositive individuals: a nationwide population-based matched cohort study', Clinical Microbiology and Infection, vol. 30, no. 2, pp. 231-239. https://doi.org/10.1016/j.cmi.2023.10.017

APA

Tetens, M. M., Omland, L. H., Dessau, R., Ellermann-Eriksen, S., Andersen, N. S., Jørgensen, C. S., Østergaard, C., Bodilsen, J., Søgaard, K. K., Bangsborg, J., Nielsen, A. C., Møller, J. K., Chen, M., Niemann, C. U., Lebech, A. M., & Obel, N. (2024). Risk of haematologic cancers among individuals tested for Borrelia burgdorferi antibodies, and Borrelia burgdorferi seropositive individuals: a nationwide population-based matched cohort study. Clinical Microbiology and Infection, 30(2), 231-239. https://doi.org/10.1016/j.cmi.2023.10.017

Vancouver

Tetens MM, Omland LH, Dessau R, Ellermann-Eriksen S, Andersen NS, Jørgensen CS et al. Risk of haematologic cancers among individuals tested for Borrelia burgdorferi antibodies, and Borrelia burgdorferi seropositive individuals: a nationwide population-based matched cohort study. Clinical Microbiology and Infection. 2024;30(2):231-239. https://doi.org/10.1016/j.cmi.2023.10.017

Author

Tetens, Malte M. ; Omland, Lars Haukali ; Dessau, Ram ; Ellermann-Eriksen, Svend ; Andersen, Nanna S. ; Jørgensen, Charlotte Sværke ; Østergaard, Christian ; Bodilsen, Jacob ; Søgaard, Kirstine K. ; Bangsborg, Jette ; Nielsen, Alex Christian ; Møller, Jens Kjølseth ; Chen, Ming ; Niemann, Carsten Utoft ; Lebech, Anne Mette ; Obel, Niels. / Risk of haematologic cancers among individuals tested for Borrelia burgdorferi antibodies, and Borrelia burgdorferi seropositive individuals : a nationwide population-based matched cohort study. In: Clinical Microbiology and Infection. 2024 ; Vol. 30, No. 2. pp. 231-239.

Bibtex

@article{abe11d44218a445b930694b466956ed3,
title = "Risk of haematologic cancers among individuals tested for Borrelia burgdorferi antibodies, and Borrelia burgdorferi seropositive individuals: a nationwide population-based matched cohort study",
abstract = "Objectives: In a nationwide, matched cohort study, we aimed to investigate risks of haematologic cancers among individuals tested for Borrelia burgdorferi (Bb) antibodies, and among serum Bb seropositive individuals. Methods: We identified all Bb seropositive individuals in Denmark (1993–2020) (n = 52 200) and constructed two age- and sex-matched comparison cohorts: (a) Bb seronegative controls (n = 104 400) and (b) background population controls (n = 261 000). We calculated short-term OR (aOR) (<1 month of study inclusion), and long-term hazard ratios (aHR) (>1 month after study inclusion) adjusted for age and sex. We stratified seropositive individuals on only Bb-IgM seropositive (n = 26 103), only Bb-IgG seropositive (n = 18 698), and Bb-IgM-and-IgG seropositive (n = 7399). Results: Compared with the background population, individuals tested for Bb antibodies had increased short-term (aOR: 12.6, 95% CI: 10.1–15.6) and long-term (aHR: 1.3, 95% CI: 1.2–1.4) risk of haematologic cancers. The Bb seropositive individuals had no increased risk of haematologic cancers compared with those who tested negative for Bb, except that Bb-IgM-and-IgG seropositive individuals had increased long-term risk of chronic lymphatic leukaemia (aHR: 2.0, 95% CI: 1.2–3.4). Discussion: Our results suggest that Bb antibody testing is included in the work-up of unspecific symptoms preceding diagnosis of haematologic cancers. Bb-IgM-and-IgG seropositivity was associated with a two-fold increased long-term risk of chronic lymphatic leukaemia, which warrants further investigation.",
keywords = "Borrelia burgdorferi sensu lato, Borreliosis, Cohort study, Haematologic cancer, Leukaemia, Lyme disease, Serology",
author = "Tetens, {Malte M.} and Omland, {Lars Haukali} and Ram Dessau and Svend Ellermann-Eriksen and Andersen, {Nanna S.} and J{\o}rgensen, {Charlotte Sv{\ae}rke} and Christian {\O}stergaard and Jacob Bodilsen and S{\o}gaard, {Kirstine K.} and Jette Bangsborg and Nielsen, {Alex Christian} and M{\o}ller, {Jens Kj{\o}lseth} and Ming Chen and Niemann, {Carsten Utoft} and Lebech, {Anne Mette} and Niels Obel",
note = "Publisher Copyright: {\textcopyright} 2023 The Authors",
year = "2024",
doi = "10.1016/j.cmi.2023.10.017",
language = "English",
volume = "30",
pages = "231--239",
journal = "Clinical Microbiology and Infection",
issn = "1198-743X",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Risk of haematologic cancers among individuals tested for Borrelia burgdorferi antibodies, and Borrelia burgdorferi seropositive individuals

T2 - a nationwide population-based matched cohort study

AU - Tetens, Malte M.

AU - Omland, Lars Haukali

AU - Dessau, Ram

AU - Ellermann-Eriksen, Svend

AU - Andersen, Nanna S.

AU - Jørgensen, Charlotte Sværke

AU - Østergaard, Christian

AU - Bodilsen, Jacob

AU - Søgaard, Kirstine K.

AU - Bangsborg, Jette

AU - Nielsen, Alex Christian

AU - Møller, Jens Kjølseth

AU - Chen, Ming

AU - Niemann, Carsten Utoft

AU - Lebech, Anne Mette

AU - Obel, Niels

N1 - Publisher Copyright: © 2023 The Authors

PY - 2024

Y1 - 2024

N2 - Objectives: In a nationwide, matched cohort study, we aimed to investigate risks of haematologic cancers among individuals tested for Borrelia burgdorferi (Bb) antibodies, and among serum Bb seropositive individuals. Methods: We identified all Bb seropositive individuals in Denmark (1993–2020) (n = 52 200) and constructed two age- and sex-matched comparison cohorts: (a) Bb seronegative controls (n = 104 400) and (b) background population controls (n = 261 000). We calculated short-term OR (aOR) (<1 month of study inclusion), and long-term hazard ratios (aHR) (>1 month after study inclusion) adjusted for age and sex. We stratified seropositive individuals on only Bb-IgM seropositive (n = 26 103), only Bb-IgG seropositive (n = 18 698), and Bb-IgM-and-IgG seropositive (n = 7399). Results: Compared with the background population, individuals tested for Bb antibodies had increased short-term (aOR: 12.6, 95% CI: 10.1–15.6) and long-term (aHR: 1.3, 95% CI: 1.2–1.4) risk of haematologic cancers. The Bb seropositive individuals had no increased risk of haematologic cancers compared with those who tested negative for Bb, except that Bb-IgM-and-IgG seropositive individuals had increased long-term risk of chronic lymphatic leukaemia (aHR: 2.0, 95% CI: 1.2–3.4). Discussion: Our results suggest that Bb antibody testing is included in the work-up of unspecific symptoms preceding diagnosis of haematologic cancers. Bb-IgM-and-IgG seropositivity was associated with a two-fold increased long-term risk of chronic lymphatic leukaemia, which warrants further investigation.

AB - Objectives: In a nationwide, matched cohort study, we aimed to investigate risks of haematologic cancers among individuals tested for Borrelia burgdorferi (Bb) antibodies, and among serum Bb seropositive individuals. Methods: We identified all Bb seropositive individuals in Denmark (1993–2020) (n = 52 200) and constructed two age- and sex-matched comparison cohorts: (a) Bb seronegative controls (n = 104 400) and (b) background population controls (n = 261 000). We calculated short-term OR (aOR) (<1 month of study inclusion), and long-term hazard ratios (aHR) (>1 month after study inclusion) adjusted for age and sex. We stratified seropositive individuals on only Bb-IgM seropositive (n = 26 103), only Bb-IgG seropositive (n = 18 698), and Bb-IgM-and-IgG seropositive (n = 7399). Results: Compared with the background population, individuals tested for Bb antibodies had increased short-term (aOR: 12.6, 95% CI: 10.1–15.6) and long-term (aHR: 1.3, 95% CI: 1.2–1.4) risk of haematologic cancers. The Bb seropositive individuals had no increased risk of haematologic cancers compared with those who tested negative for Bb, except that Bb-IgM-and-IgG seropositive individuals had increased long-term risk of chronic lymphatic leukaemia (aHR: 2.0, 95% CI: 1.2–3.4). Discussion: Our results suggest that Bb antibody testing is included in the work-up of unspecific symptoms preceding diagnosis of haematologic cancers. Bb-IgM-and-IgG seropositivity was associated with a two-fold increased long-term risk of chronic lymphatic leukaemia, which warrants further investigation.

KW - Borrelia burgdorferi sensu lato

KW - Borreliosis

KW - Cohort study

KW - Haematologic cancer

KW - Leukaemia

KW - Lyme disease

KW - Serology

U2 - 10.1016/j.cmi.2023.10.017

DO - 10.1016/j.cmi.2023.10.017

M3 - Journal article

C2 - 37871679

AN - SCOPUS:85176099586

VL - 30

SP - 231

EP - 239

JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

SN - 1198-743X

IS - 2

ER -

ID: 381722944