Novel perspectives regarding the pathology, inflammation, and biomarkers of acute respiratory distress syndrome
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- ijms-22-00205
Final published version, 840 KB, PDF document
Acute respiratory distress syndrome (ARDS) is an acute inflammation of the lung resulting from damage to the alveolar–capillary membrane, and it is diagnosed using a combination of clinical and physiological variables. ARDS develops in approximately 10% of hospitalised patients with pneumonia and has a mortality rate of approximately 40%. Recent research has identified several biomarkers associated with ARDS pathophysiology, and these may be useful for diagnosing and monitoring ARDS. They may also highlight potential therapeutic targets. This review summarises our current understanding of those clinical biomarkers: (1) biomarkers of alveolar and bronchiolar injury, (2) biomarkers of endothelial damage and coagulation, and (3) biomarkers for treatment responses.
Original language | English |
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Article number | 205 |
Journal | International Journal of Molecular Sciences |
Volume | 22 |
Issue number | 1 |
Pages (from-to) | 1-16 |
Number of pages | 16 |
ISSN | 1661-6596 |
DOIs | |
Publication status | Published - 1 Jan 2021 |
Bibliographical note
Funding Information:
Funding: This study was funded by the Danish Regions Medical Fund (grant no. 5894/16) and the Danish Council for Independent Research (grant no. 6110-00268B). The research salary of PS was sponsored by Herlev and Gentofte Hospital, University of Copenhagen.
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
- Acute respiratory distress syndrome, Biomarkers, Inflammation, Molecular pathway, Therapeutics
Research areas
ID: 282529560