A New Technology for Detecting Cerebral Blood Flow: A Comparative Study of Ultrasound Tagged NIRS and (133)Xe-SPECT
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There is a need for real-time non-invasive, continuous monitoring of cerebral blood flow (CBF) during surgery, in intensive care units and clinical research. We investigated a new non-invasive hybrid technology employing ultrasound tagged near infrared spectroscopy (UT-NIRS) that may estimate changes in CBF using a cerebral blood flow index (CFI). Changes over time for UT-NIRS CFI and (133)Xenon single photon emission computer tomography ((133)Xe-SPECT) CBF data were assessed in 10 healthy volunteers after an intravenous bolus of acetazolamide. UT-NIRS CFI was measured continuously and SPECT CBF was measured at baseline, 15 and 60 min after acetazolamide. We found significant changes over time in CFI by UT-NIRS and CBF by SPECT after acetazolamide (P ≤ 0.001). Post hoc tests showed a significant increase in CFI (P = 0.011) and SPECT CBF (P
| Original language | English |
|---|---|
| Journal | Neurocritical Care |
| Volume | 17 |
| Issue number | 1 |
| Pages (from-to) | 139-45 |
| Number of pages | 7 |
| ISSN | 1541-6933 |
| DOIs | |
| Publication status | Published - 2012 |
ID: 48419721