Calcitonin Gene-Related Peptide (CGRP) and Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in Migraine Pathogenesis

Research output: Contribution to journal › Review › Research › peer-review

Standard

Calcitonin Gene-Related Peptide (CGRP) and Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in Migraine Pathogenesis. / Christensen, Casper Emil; Ashina, Messoud; Amin, Faisal Mohammad.

In: Pharmaceuticals, Vol. 15, No. 10, 1189, 2022.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Christensen, CE, Ashina, M & Amin, FM 2022, 'Calcitonin Gene-Related Peptide (CGRP) and Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in Migraine Pathogenesis', Pharmaceuticals, vol. 15, no. 10, 1189. https://doi.org/10.3390/ph15101189

APA

Christensen, C. E., Ashina, M., & Amin, F. M. (2022). Calcitonin Gene-Related Peptide (CGRP) and Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in Migraine Pathogenesis. Pharmaceuticals, 15(10), [1189]. https://doi.org/10.3390/ph15101189

Vancouver

Christensen CE, Ashina M, Amin FM. Calcitonin Gene-Related Peptide (CGRP) and Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in Migraine Pathogenesis. Pharmaceuticals. 2022;15(10). 1189. https://doi.org/10.3390/ph15101189

Author

Christensen, Casper Emil ; Ashina, Messoud ; Amin, Faisal Mohammad. / Calcitonin Gene-Related Peptide (CGRP) and Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in Migraine Pathogenesis. In: Pharmaceuticals. 2022 ; Vol. 15, No. 10.

Bibtex

@article{1e3ecd0badc84546a2c057db3d96f0e5,
title = "Calcitonin Gene-Related Peptide (CGRP) and Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in Migraine Pathogenesis",
abstract = "Migraine is a prevalent and debilitating neurologic disorder. Advancements in understanding the underlying pathophysiological mechanisms are spearheading the effort to introduce disease-specific treatment options. In recent years this effort has largely focused on alteration of endogenous neuropeptide signaling, namely the peptides calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating polypeptide (PACAP). Human studies into the pathophysiological underpinnings of CGRP and PACAP in migraine are manifold and here we review the works investigating these neuropeptides in patients suffering from migraine in order to elucidate the background for developing new treatment options for this vastly disabling disorder.",
keywords = "cerebral artery, headache, meningeal artery, migraine, MR-angiography, MRI, neurovascular",
author = "Christensen, {Casper Emil} and Messoud Ashina and Amin, {Faisal Mohammad}",
note = "Publisher Copyright: {\textcopyright} 2022 by the authors.",
year = "2022",
doi = "10.3390/ph15101189",
language = "English",
volume = "15",
journal = "Pharmaceuticals",
issn = "1424-8247",
publisher = "M D P I AG",
number = "10",

}

RIS

TY - JOUR

T1 - Calcitonin Gene-Related Peptide (CGRP) and Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in Migraine Pathogenesis

AU - Christensen, Casper Emil

AU - Ashina, Messoud

AU - Amin, Faisal Mohammad

N1 - Publisher Copyright: © 2022 by the authors.

PY - 2022

Y1 - 2022

N2 - Migraine is a prevalent and debilitating neurologic disorder. Advancements in understanding the underlying pathophysiological mechanisms are spearheading the effort to introduce disease-specific treatment options. In recent years this effort has largely focused on alteration of endogenous neuropeptide signaling, namely the peptides calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating polypeptide (PACAP). Human studies into the pathophysiological underpinnings of CGRP and PACAP in migraine are manifold and here we review the works investigating these neuropeptides in patients suffering from migraine in order to elucidate the background for developing new treatment options for this vastly disabling disorder.

AB - Migraine is a prevalent and debilitating neurologic disorder. Advancements in understanding the underlying pathophysiological mechanisms are spearheading the effort to introduce disease-specific treatment options. In recent years this effort has largely focused on alteration of endogenous neuropeptide signaling, namely the peptides calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating polypeptide (PACAP). Human studies into the pathophysiological underpinnings of CGRP and PACAP in migraine are manifold and here we review the works investigating these neuropeptides in patients suffering from migraine in order to elucidate the background for developing new treatment options for this vastly disabling disorder.

KW - cerebral artery

KW - headache

KW - meningeal artery

KW - migraine

KW - MR-angiography

KW - MRI

KW - neurovascular

U2 - 10.3390/ph15101189

DO - 10.3390/ph15101189

M3 - Review

C2 - 36297301

AN - SCOPUS:85140791064

VL - 15

JO - Pharmaceuticals

JF - Pharmaceuticals

SN - 1424-8247

IS - 10

M1 - 1189

ER -

ID: 346409948