Can nitric oxide induce migraine in normal individuals?
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Can nitric oxide induce migraine in normal individuals? / Olesen, Jes; Ashina, Messoud.
In: Cephalalgia : an international journal of headache, Vol. 35, No. 12, 10.2015, p. 1125-9.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Can nitric oxide induce migraine in normal individuals?
AU - Olesen, Jes
AU - Ashina, Messoud
N1 - © International Headache Society 2015.
PY - 2015/10
Y1 - 2015/10
N2 - INTRODUCTION: For many years, scientists have debated the possibility that an individual "migraine threshold" determines the likelihood with which individuals may express migraine attacks.DISCUSSION: Recent discoveries provided evidence for both genetic and environmental influences on individual migraine expression. The question is whether any person may express a migraine attack given a sufficiently strong stimulus or provocation. Here, we reviewed and discussed the ability of nitric oxide to induce migraine-like attacks in normal individuals.CONCLUSION: Experimental data show that normal individuals may develop a migraine-like attack and that the human data point to different ways of further developing existing animal and human models.
AB - INTRODUCTION: For many years, scientists have debated the possibility that an individual "migraine threshold" determines the likelihood with which individuals may express migraine attacks.DISCUSSION: Recent discoveries provided evidence for both genetic and environmental influences on individual migraine expression. The question is whether any person may express a migraine attack given a sufficiently strong stimulus or provocation. Here, we reviewed and discussed the ability of nitric oxide to induce migraine-like attacks in normal individuals.CONCLUSION: Experimental data show that normal individuals may develop a migraine-like attack and that the human data point to different ways of further developing existing animal and human models.
U2 - 10.1177/0333102414566201
DO - 10.1177/0333102414566201
M3 - Journal article
C2 - 25573895
VL - 35
SP - 1125
EP - 1129
JO - Cephalalgia
JF - Cephalalgia
SN - 0800-1952
IS - 12
ER -
ID: 162380007