Carbon monoxide may be an important molecule in migraine and other headaches
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Carbon monoxide may be an important molecule in migraine and other headaches. / Arngrim, Nanna; Schytz, Henrik W; Hauge, Mette K; Ashina, Messoud; Olesen, Jes.
In: Cephalalgia : an international journal of headache, Vol. 34, No. 14, 12.2014, p. 1169-1180.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Carbon monoxide may be an important molecule in migraine and other headaches
AU - Arngrim, Nanna
AU - Schytz, Henrik W
AU - Hauge, Mette K
AU - Ashina, Messoud
AU - Olesen, Jes
N1 - © International Headache Society 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.
PY - 2014/12
Y1 - 2014/12
N2 - INTRODUCTION: Carbon monoxide was previously considered to just be a toxic gas. A wealth of recent information has, however, shown that it is also an important endogenously produced signalling molecule involved in multiple biological processes. Endogenously produced carbon monoxide may thus play an important role in nociceptive processing and in regulation of cerebral arterial tone.DISCUSSION: Carbon monoxide-induced headache shares many characteristics with migraine and other headaches. The mechanisms whereby carbon monoxide causes headache may include hypoxia, nitric oxide signalling and activation of cyclic guanosine monophosphate pathways. Here, we review the literature about carbon monoxide-induced headache and its possible mechanisms.CONCLUSION: We suggest, for the first time, that carbon monoxide may play an important role in the mechanisms of migraine and other headaches.
AB - INTRODUCTION: Carbon monoxide was previously considered to just be a toxic gas. A wealth of recent information has, however, shown that it is also an important endogenously produced signalling molecule involved in multiple biological processes. Endogenously produced carbon monoxide may thus play an important role in nociceptive processing and in regulation of cerebral arterial tone.DISCUSSION: Carbon monoxide-induced headache shares many characteristics with migraine and other headaches. The mechanisms whereby carbon monoxide causes headache may include hypoxia, nitric oxide signalling and activation of cyclic guanosine monophosphate pathways. Here, we review the literature about carbon monoxide-induced headache and its possible mechanisms.CONCLUSION: We suggest, for the first time, that carbon monoxide may play an important role in the mechanisms of migraine and other headaches.
U2 - 10.1177/0333102414534085
DO - 10.1177/0333102414534085
M3 - Review
C2 - 24816616
VL - 34
SP - 1169
EP - 1180
JO - Cephalalgia
JF - Cephalalgia
SN - 0800-1952
IS - 14
ER -
ID: 138383888