Change in brain network connectivity during PACAP38-induced migraine attacks: A resting-state functional MRI study
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Change in brain network connectivity during PACAP38-induced migraine attacks : A resting-state functional MRI study. / Amin, Faisal Mohammad; Hougaard, Anders; Magon, Stefano; Asghar, Mohammad Sohail; Ahmad, Nur Nabil; Rostrup, Egill; Sprenger, Till; Ashina, Messoud.
In: Neurology, Vol. 86, No. 2, 12.01.2016, p. 180-7.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Change in brain network connectivity during PACAP38-induced migraine attacks
T2 - A resting-state functional MRI study
AU - Amin, Faisal Mohammad
AU - Hougaard, Anders
AU - Magon, Stefano
AU - Asghar, Mohammad Sohail
AU - Ahmad, Nur Nabil
AU - Rostrup, Egill
AU - Sprenger, Till
AU - Ashina, Messoud
N1 - © 2015 American Academy of Neurology.
PY - 2016/1/12
Y1 - 2016/1/12
N2 - OBJECTIVE: To investigate resting-state functional connectivity in the salience network (SN), the sensorimotor network (SMN), and the default mode network (DMN) during migraine attacks induced by pituitary adenylate cyclase-activating polypeptide-38 (PACAP38).METHODS: In a double-blind, randomized study, 24 female migraine patients without aura received IV PACAP38 or vasoactive intestinal polypeptide (VIP) over 20 minutes. Both peptides are closely related and cause vasodilation, but only PACAP38 induces migraine attacks. VIP was therefore used as active placebo. Resting-state functional MRI was recorded before and during PACAP38-induced migraine attacks and before and after VIP infusion. We analyzed data by Statistical Parametric Mapping 8 and the Resting-State fMRI Data Analysis Toolkit for Matlab in a seed-based fashion.RESULTS: PACAP38 (n = 16) induced migraine attacks and increased connectivity with the bilateral opercular part of the inferior frontal gyrus in the SN. In SMN, there was increased connectivity with the right premotor cortex and decreased connectivity with the left visual cortex. Several areas showed increased (left primary auditory, secondary somatosensory, premotor, and visual cortices) and decreased (right cerebellum and left frontal lobe) connectivity with DMN. We found no resting-state network changes after VIP (n = 15).CONCLUSIONS: PACAP38-induced migraine attack is associated with altered connectivity of several large-scale functional networks of the brain.
AB - OBJECTIVE: To investigate resting-state functional connectivity in the salience network (SN), the sensorimotor network (SMN), and the default mode network (DMN) during migraine attacks induced by pituitary adenylate cyclase-activating polypeptide-38 (PACAP38).METHODS: In a double-blind, randomized study, 24 female migraine patients without aura received IV PACAP38 or vasoactive intestinal polypeptide (VIP) over 20 minutes. Both peptides are closely related and cause vasodilation, but only PACAP38 induces migraine attacks. VIP was therefore used as active placebo. Resting-state functional MRI was recorded before and during PACAP38-induced migraine attacks and before and after VIP infusion. We analyzed data by Statistical Parametric Mapping 8 and the Resting-State fMRI Data Analysis Toolkit for Matlab in a seed-based fashion.RESULTS: PACAP38 (n = 16) induced migraine attacks and increased connectivity with the bilateral opercular part of the inferior frontal gyrus in the SN. In SMN, there was increased connectivity with the right premotor cortex and decreased connectivity with the left visual cortex. Several areas showed increased (left primary auditory, secondary somatosensory, premotor, and visual cortices) and decreased (right cerebellum and left frontal lobe) connectivity with DMN. We found no resting-state network changes after VIP (n = 15).CONCLUSIONS: PACAP38-induced migraine attack is associated with altered connectivity of several large-scale functional networks of the brain.
KW - Adult
KW - Brain
KW - Brain Mapping
KW - Double-Blind Method
KW - Female
KW - Humans
KW - Magnetic Resonance Imaging
KW - Migraine Disorders
KW - Nerve Net
KW - Neurotransmitter Agents
KW - Pituitary Adenylate Cyclase-Activating Polypeptide
KW - Young Adult
KW - Journal Article
KW - Randomized Controlled Trial
KW - Research Support, Non-U.S. Gov't
U2 - 10.1212/WNL.0000000000002261
DO - 10.1212/WNL.0000000000002261
M3 - Journal article
C2 - 26674334
VL - 86
SP - 180
EP - 187
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 2
ER -
ID: 164517980